Orr Lab at WashU | PI: Miranda Orr, PhD | Lab Interests: Aging, Alzheimer's disease, Neurodegenerative disorders, Tau, and Senescence
St. Louis, MO
Joined April 2021
- Tweets70
- Following103
- Followers270
- Likes122
OrrLab retweeted
Congratulations to the 10 Goodes Prize winners who along with the ADDF have shaped the last decade of #Alzheimers research around the #biologyofaging, moving the field closer to treating the disease with #precisionmedicine. Hope is here. bit.ly/3B9HPTG
OrrLab retweeted
NanoString is excited to announce it will be acquired by Bruker Corporation in a $392.6 million agreement. We are grateful for our dedicated employees and customers! #futurelooksbright!
bit.ly/3vMCkbz
OrrLab retweeted
Thank you @TheADDF for bringing together at#ADPD2024 this impactful roundtable on Novel Approches in AD Research guided by the Biology of Aging with @MiiaKivipelto @jacques_touchon @a_hfillit Miranda Orr @WakeForest @DrJeffCummings – at Oeiras, Portugal
OrrLab retweeted
TO ALL #spatial #genomics CEOs!
Please read our Comment @GENbio
“Sounding an Alarm over Spatial Biology”
Scientists’ call for action. We are all part one community and have to act accordingly. Don’t let financial interests ruin innovation.
genengnews.com/topics/bioper…
OrrLab retweeted
.@nanostringtech is here to stay!
Joe Beechem speaks up @GENbio:
“We are not going anywhere”.
Only #diversity will drive #innovation in Spatial Genomics!
#youarenotalone
genengnews.com/topics/omics/…
OrrLab retweeted
It has been fun working with @RCFNeuro, @alzassociation, @CurePSP and other organizers to develop the scientific program for #Tau2024! My lab will be there - will yours? March 25-26, 2024 in Washington, DC. Register now: alz.org/Tau
Thrilled to help @jme_walker and her team explore differences in NFTs between #PART and #AD using GeoMx DSP! Awesome work! #nanostrung
#Spatialproteomics reveal mechanisms of development and progression in #Alzheimer'sdisease. 🧠 👉bit.ly/3ZL5zWK
@Orr_lab from Wake Forest University used GeoMx DSP to show proteome differences at the basis of Aβ and p-tau distribution and pathogenicity.
#Fridayread
OrrLab retweeted
Happy to share our latest publication - we used spatial proteomics to compare #PART and #AD looking at differences between NFTs, normal neurons and their microenvironments in the CA1 and CA2 subregions of the #hippocampus, as well as the entorhinal cortex. doi.org/10.1002/alz.13484
OrrLab retweeted
🧟 The @Orr_Lab is researching senescent cells and their impact on memory problems. Could targeting "zombie" cells be a breakthrough in #Alzheimers treatments? Learn more: brnw.ch/21wD7Hq
OrrLab retweeted
ADDF-funded @Orr_Lab's #CombinationTherapy clinical trial on senescent cells supports the ADDF's core belief that the next generation of #Alzheimers drugs will be guided by #novel targets based on the #BiologyOfAging. More on the trial in @mcknightsltcn: bit.ly/3rgc2Mq
OrrLab retweeted
Last week's 9th Annual Melvin R. Goodes Prize Luncheon & symposium reflected on recent breakthroughs in #Alzheimers research. This year, the ADDF honored DxA-funded scientist, Dr. Rhoda Au for her work with #DigitalBiomarkers and #diagnostics for early Alzheimer's detection.
OrrLab retweeted
First feasibility study of orally-delivered #senolytic therapy in #Alzheimersdisease reports favorable safety data and penetrance of #dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers @wakeforestmed @MitziMGonzales @Orr_Lab
nature.com/articles/s41591-0…
OrrLab retweeted
Research from @Orr_Lab shows that treatment to clear #senescent cells in #Alzheimer’s disease is safe in Phase I clinical trial. Learn more about the study, which appears in @NatureMedicine. @TheADDF @nanostringtech brnw.ch/21wCn5E
OrrLab retweeted
Results from a new study led by ADDF-funded @Orr_Lab further validate that novel approaches to #Alzheimers centered around the biology of aging will guide the next generation of therapeutics. Read our statement on the senescent cell treatment study here: bit.ly/3RdEQjd
Exciting news! Led by @MitziGonzales, our team’s Phase I trial testing #senolytics in #Alzheimer’s disease reports on brain penetrance, safety, and biomarkers! 🧠 Phase 2 trial supported by @TheADDF is underway! #JoinOurStudy #SToMP-AD #Senescence #Aging nature.com/articles/s41591-0…
OrrLab retweeted
A fun day 1 at #AAIC23 with @theREALaivisaur @bbonakda @MaggieFlanagan @Orr_Lab @JohnCraryMDPHD ☺️🧠🍨
OrrLab retweeted
Thank you to all who joined the NSC Directors Symposium at #AGE2023!
The session featured presentations from pilot grantees George Sutphin @senmorteco, Miranda Orr @Orr_Lab, Andrey Parkhitko, Anna @ThalackerMercer, Danielle Bruns, @SimoneSidoli, @MariaMMihaylova, & @CristalM_Hill
OrrLab retweeted
More than 6.7M Americans and 57M people worldwide are living with #Alzheimers today. A new gift from the #Lauders ensures the #ADDF will be able to continue funding the most promising science around the globe until we defeat this disease: bit.ly/3G3gNNG
OrrLab retweeted
Within the next 15 years, ADDF will help bring to market a new generation of drugs based on the #biologyofaging that can be combined with other therapies, including anti-amyloids, to defeat #Alzheimers thanks to a historic gift from the #Lauder family: bit.ly/3G3gNNG