The dementia "obesity paradox" looks like reverse causation: people lose weight before diagnosis, so late-life thinness read as protection. A new Nature Reviews Neurology review points to midlife as the window, with waist and muscle mattering more than BMI.
Oncologist Siddhartha Mukherjee's reframe: think of ageing diseases, osteoarthritis included, as "regenerative failure", tissue losing its ability to repair itself, rather than a list of separate diseases to prevent.
"Omega-3s work as well as ibuprofen" claims usually stretch chronic-pain research (41 trials, real effect, but builds over weeks-months) into an acute-relief claim it was never testing. Ibuprofen blocks inflammation directly within an hour.
Peter Attia's framing: your boat is sinking, you grab the liferaft before the book. Obvious with minutes to decide.
His point: people spend hours perfecting the ideal training split while training three days one week, zero the next.
~43% of daily behaviour is habitual, and it's triggered by location and routine, not by current goals or intentions. People keep doing the habitual thing regardless of what they say they want, then explain it afterward as a choice.
New COSMOS trial data: a basic multivitamin raised omega-3 levels after 2 years, despite containing no omega-3 itself (likely via cofactors needed to process fatty acids). Most "slower aging" findings didn't survive statistical correction.
What did hold up across 3 sub-trials: a real cognitive benefit. Nuanced, not useless, not magic.
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New study: the most overconfident people weren't the ones who knew nothing, or the ones who knew the most. It was people with just a small "blip" of recent knowledge, enough to feel certain, not enough to see what they were missing. .
Headline: "cheese protects your brain." Study: high-fat cheese linked to 13% lower dementia risk over 25 years. Also buried in the same study: high-fat cheese eaters already had less diabetes, hypertension, and stroke. Classic confounding.
High blood pressure.
Mine was picked up at a routine check in June. No symptoms, train consistently, eat well most of the time. Still showed up. Now managing it with two low-dose medications and weight loss, checking regularly rather than waiting for the next annual visit.
GLP-1 drugs are now approved for diabetes, obesity, heart disease, kidney disease, sleep apnea, and liver disease, and being studied for substance use disorder and brain injury. The catch: trials show the outcome improved, not why.
Oρƚιɱιʂҽ Pҽɾϝσrm & WҽʅʅႦҽιɳɠ retweeted
It’s hard to imagine many people having a bigger impact than Dolly Parton. Born in a one-room cabin, she earned 11 Grammys and an Emmy, built a business empire, helped millions of kids learn to read, and — as if that wasn’t enough — helped accelerate the research that led to the Moderna COVID vaccine. What a life. Michelle and I are thinking of Dolly’s family and her many, many fans.
Breaking News: Dolly Parton, the country singer, songwriter, entertainer and entrepreneur known for her outsize persona and prodigious vision and talent that placed her in a class by herself, has died at 80. nyti.ms/45Prr77


