Finding new drugs to treat TB following open-source principles - join us! Sister projects at @OSantibiotics, @MycetOS and @O_S_M.
Joined January 2014
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The Open Source TB account has been a little quiet of late but what a great post to make our comeback with! Carlota is working on the diversity-oriented synthesis portion of #OSTBSeries4, which you can read more about here: github.com/OpenSourceTB/OSTB…
So excited to have a new honours student join the Rutledge group - Carlota has just started working on the @OpenSourceTB project with me!
Thanks for the shoutout! Our most recent work is now up on @GitHub at github.com/OpenSourceTB/.
Or you can check out the #OpenSourceTB or #OpenSourceDrugDiscovery hashtags to find out more!
#OAWeek shoutout to The Open Source Tuberculosis Consortium (@OpenSourceTB), which is trying a different approach to curing #Tuberculosis. Guided by #opensource principles, everything is open and anyone can contribute. Check them out here: opensourcetb.org/
COVID-19 restrictions have kept us out of the lab, so unfortunately we don't have any more current synthetic work to discuss right now. But that doesn't stop you from getting involved - #OpenSourceDrugDiscovery projects are larger than a single lab!
#OpenSourceTB's diversity oriented synthesis also includes a double allylation of boc-protected linear polyamine (analogous to the propargylation we mentioned last week).
Theoretically, this will help us install other functionalities...
..but we had way more trouble with this one than expected - read about our trials and tribulations on @GitHub: github.com/KlementineJBS/ELN…
#OpenSourceTB #OpenSourceDrugDiscovery #OpenScience
We’ve tried THF instead of DMF, + different bases (KOH and NaOH) but our yields are still low..,we think we’re getting the mono-allylated side product, which complicates purification.
Any ideas? We’d love suggestions!
#ChemTwitter #RealTimeChem #MedChem #OpenSourceTB
This fab illustration of the 6 laws of #OpenSourceDrugDiscovery features our sister project @O_S_M but the same principles apply to our work, too!
If you're curious about them, read the paper here: doi.org/10.1002/cmdc.2019005…
#OpenScience
A vision in orange, #Malaria #Innovator @MatToddChem as envisioned by @_dangerouscake bit.ly/MatPortrait
Series 4 of #OpenSourceTB has a focus on diversity-oriented synthesis. Here’s one of the routes we planned to install a non-activated alkene. Our first reaction (acylation) had great yields…
#MedChem #ChemTwitter #OpenSourceDrugDiscovery #OpenScience
…but we struggled to purify the product of the Michaelis-Arbuzov reaction. We tried a column (DCM:MeOH with 10% NH4) + trituration with toluene, then lockdown interfered.
Have you got any ideas for purifying this? We’d love to hear!
#ChemTwitter #RealTimeChem #MedChem
#OpenSourceTB uses @GitHub to easily share our data & experimental methods and collaborate with others - check it out here! github.com/OpenSourceTB/
#OpenSourceDrugDiscovery #OpenScience
So good to be able to work on our paper about using @GitHub as an ELN *in person* with @krscroggie 😊
Open Source TB retweeted
The Tuberculosis Drug Accelerator, an experiment designed to facilitate collaboration in drug discovery, has reached a 10-year landmark.
Carl Nathan @WeillCornell and colleagues review the consortium’s achievements, advantages and limitations. #TB
nature.com/articles/s41591-0…
We're also not the only ones trying to make #DrugDiscovery more open!
Read about Huntington's disease reasearcher Dr Rachel Harding's experiences with #OpenScience here:
doi.org/10.1371/journal.pbio… | @PLOSBiology
#OpenSourceDrugDiscovery
Curious about what success #OpenSourceDrugDiscovery has had so far?
Well, the easiest one to point to is the identification of a new resolution approach for #Praziquantel (used to treat schistosomiasis).
doi.org/10.1371/journal.pntd… | @MatToddChem @PLOSNTDs
Did you know that 1.4 million people died from #Tuberculosis in 2019? (Ref - @WHO)
The UN has a goal to #EndTB by 2030 - only 9 years from now. But typical #DrugDiscovery pipelines take 10+ years...
#OpenSourceDrugDiscovery aims to accelerate that process by sharing ideas and data openly, and encouraging collaboration.
We're hopeful that these #OpenScience principles will help us finding new drugs to treat #Tuberculosis and thus save millions of lives!
Some interesting #DrugDiscovery work that could potentially impact how we approach future series of #OpenSourceTB!
#Tuberculosis
Tuberculosis Essential Gene Index of Vulnerability Points to Promising, Underexplored Targets
Researchers say the ability to identify and prioritize vulnerable essential genes provides a roadmap to reinvigorate target-based drug discovery in TB. Read more:ow.ly/mMZ050FKcSq
We started trying to use boc-protection to make some bis-functionalised linear polyamines - the plan was to propargylate the protected amine then use a naphthyl-azide coupling partner for a click reaction.
#RealTimeChem #OpenSourceTB #ChemTwitter #MedChem #DrugDiscovery
We're struggling to isolate pure product - we think partially bc the reaction mixture contains both mono- and bis-propargylated amine. Read about our attempts (and make suggestions!) here: github.com/KlementineJBS/ELN…
Any ideas #ChemTwitter?
#RealTimeChem #MedChem #OpenSourceTB
We're also keen for suggestions about other ways to do the reaction, or other sources of error - have you done a similar reaction with a different solvent? Did you get better results?
Let us know & maybe we can help each other!
#ChemTwittter #RealTimeChem #MedChem #OpenScience