@ONeill_Lab

We study cellular circadian rhythms at @mrc_lmb @CellBiol_MRCLMB. Account accessed by all members of the lab (inc John very very rarely)

 Cambridge, UK
www2.mrc-lmb.cam.ac.uk/groups/oneill
Joined October 2019
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Our first papers have been published in npj Biological Timing and Sleep! 🎉 We're proud to share two studies that highlight the journal's mission to showcase high quality research on all aspects of sleep, circadian and other biological rhythms: buff.ly/3xyd3CE #npjbts
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Out today! Circadian rhythms in proteome turnover, especially macromolecular complexes, which allow proteome renewal even under cellular proteostasis, osmostasis, and energy homeostasis constraints: embopress.org/doi/full/10.10…
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Our latest work is out as a preprint on #bioRxiv ! Work by @Serffest , @PriyaCrosby and many others looking at #potassium rhythms in coupling between the #circadian clock and cell cycle. Collaboration with @partchlab @ONeill_Lab and @Alestang01 biorxiv.org/content/10.1101/…
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Come join our team? We have a postdoc position open. Deadline 17th March mrc.tal.net/vx/mobile-0/appc…
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A tweet back to circadian biology: John and Andrew @DrBatmo were interviewed on the EMBO podcast about the story behind our recent paper on physiological function of red blood cell rhythms. Link below
EMBO@EMBO1 Dec 2023
In the new #EMBOPodcast, John O'Neill and Andrew Beale of @MRC_LMB talk to us about how a mysterious band on a Western blot led to a fascinating paper on circadian rhythms in red blood cells. embo.org/podcasts/the-band-a…

The band and the rhythm – Podcast – EMBO

A conversation with John O’Neill and Andrew Beale

embo.org
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And save the date for an exciting #proteostasis conference @BabrahamInst 8-9 May next year! More details will be announced soon but it’s looking like a great line-up! 4/4
Featuring the speaker details: Keynote by Rick Morimoto, other presentations by Ivana Bjedov from UCL Cancer Institute, Pedro Carvalho from University of Oxford, Tuomas Knowles from University of Cambridge, Sheena Radford from University of Leeds, Steven Spoel from University of Edinburgh, Rebecca Taylor from University of East Anglia, Paul Workman from Institute of Cancer Research

ALT Featuring the speaker details: Keynote by Rick Morimoto, other presentations by Ivana Bjedov from UCL Cancer Institute, Pedro Carvalho from University of Oxford, Tuomas Knowles from University of Cambridge, Sheena Radford from University of Leeds, Steven Spoel from University of Edinburgh, Rebecca Taylor from University of East Anglia, Paul Workman from Institute of Cancer Research

UK Proteostasis Conference. Text reads: Bringing the UK proteostasis community together. Conference organisers: Della David & Oliver Florey, Babraham Institute, Laura Itzhaki & Ritwick Sawarkar, University of Cambridge. Calendar graphic shows the event date: 8-9 May 2024 at the Babraham Institute.

ALT UK Proteostasis Conference. Text reads: Bringing the UK proteostasis community together. Conference organisers: Della David & Oliver Florey, Babraham Institute, Laura Itzhaki & Ritwick Sawarkar, University of Cambridge. Calendar graphic shows the event date: 8-9 May 2024 at the Babraham Institute.

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We've dabbled in another non-circadian project with @RachelSEdgar - showing that propylene glycol (PG) has robust virucidal activity in vitro and in vivo and efficiently abolishes influenza A and SARS-CoV-2 infectivity within airborne droplets: embopress.org/doi/full/10.15…
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Nathan = O’Neill lab axe throwing champion 👑👑👑
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In a departure from biological rhythms, we’re excited to share our work describing the role of macromolecular assembly & condensation in the acute buffering of cellular water potential, published today @Nature. A thread: 1/16 nature.com/articles/s41586-0…
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Thanks also to editors and anonymous reviewers who thoughtfully helped improve this work! and also to our funders @UKRI_News, @HFSP, @wellcometrust, @royalsociety, @EMBO, @ImperialInfect, Versus Arthritis, Grifols, the Alpha-1-Foundation, Volkswagen ‘Life’ and @PoLDresden. 15/16
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If anyone wants to know why this is relevant to understanding circadian timekeeping and the daily regulation of mammalian physiology, check out Stangherlin et al, 2021 (nature.com/articles/s41467-0…) and watch this space. There is more to come soon! 16/16

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular...

Nature Communications - Osmotic compensation by electroneutral ion transport buffers TORC1-mediated changes in the cytosolic proteome, and maintains intracellular homeostasis and cell volume over...

nature.com
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