@OChoder
Joined September 2019
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  • Following19
  • Followers81
Bright students are great comfort nowadays. Our new paper reflects the high scholarship of @Nitsana88 , who initiated great collaborations to combine genetic and automated screens with interaction modeling to predict how TmaR interacts with and controls EI cell.com/cell-reports/fullte…

Uncovering the mechanism for polar sequestration of the major bacterial sugar regulator by high-t...

The bacterial pole-localizer TmaR sequesters the sugar regulator EI in polar condensates. Albocher-Kedem et al. identify residues in EI and TmaR that impair their interaction and colocalization by...

cell.com
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Very proud of my brilliant students Priya Kannaiah and @Omer_goldb for this discovery that assigns unexpected roles to the well-studied MinD and RNase E proteins. So grateful to @TamiGeiger12 and Ora Schueler-Furman for the collaborations 🙏
The EMBO Journal@embojournal22 Jan 2024
What determines polar mRNA localization in E. coli? Shanmugapriya Kannaiah, @OChoder et al @Hujimed find the polar transcriptome to depend on MinD inhibition of RnaseE recruitment embopress.org/doi/full/10.10…
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Orna Amster-Choder retweeted
The EMBO Journal@embojournal22 Jan 2024
What determines polar mRNA localization in E. coli? Shanmugapriya Kannaiah, @OChoder et al @Hujimed find the polar transcriptome to depend on MinD inhibition of RnaseE recruitment embopress.org/doi/full/10.10…
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In these dark days successes in science are like rays of sunlight through dark clouds. Proud of my student @Tamarszoke and her mates @Omer_goldb and @Nitsana88, who showed that the pole-localizer TmaR phase separates at the poles, thus regulating motility sciencedirect.com/science/ar…
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One novelty in Tamar’s study is that, similar to disease-causing proteins, TmaR may transition to an irreversible solid state, suggesting that bacteria provide a model to study processes associated with human neurodegenerative diseases
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Congrats @Omer_goldb and my other team members for the exciting study, published yesterday in @CellReports, showing that Hfq undergoes phase separation with RNA and the relevance of this process for its activity as an RNA chaperone ...עומר לך בכוחך זה cell.com/cell-reports/fullte…

Heterotypic phase separation of Hfq is linked to its roles as an RNA chaperone

Hfq is an RNA chaperon that binds to small regulatory RNAs (sRNAs) and matches them with mRNAs, thus regulating their fate. Goldberger et al. show that, upon stress, Hfq undergoes phase separation...

cell.com
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Congrats to @tamarszoke for a identifying a novel mechanism for membrane localization of proteins that is evolutionarily conserved from bacteria to yeast mitochondria. Chapeau for promoting this original project while working on your main PhD project febs.onlinelibrary.wiley.com…

FEBS Press

Common wisdom posits that the mitochondrion has been formed early in eukaryotic cell evolution by uptake of a bacterium and its stable integration as an organelle. Szoke et al. show that bacterial...

febs.onlinelibrary.wiley.com
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Congrats @Omer_goldb for a courageous project and 1st PhD paper. Provides proof-of-concept that the polygenic theory holds for bacteria. Many happy returns 😀 sciencedirect.com/science/ar…
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