K99/R00 Postdoc @UF @LabMoehle @UF_Pharmacology Neuroscience, Movement Disorders, Electrophysiology PhD @binghamtonuniv2 Loves frogs, painting, kayaking
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Joined June 2010
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I’m thrilled to share one of my postdoctoral projects in @LabMoehle ! We created a new mouse model of GNAL-linked dystonia which shows overt dystonia-like symptoms and hyperexcitability in striatal SPNs. Thank you to everyone who contributed to this work!
biorxiv.org/content/10.1101/…
Excited to share my recent first author publication from my postdoc in @LabMoehle ! ⬇️⬇️⬇️ We investigated postive allosteric modulation of M5 muscarinic acetylcholine receptor in the 6-OHDA lesioned mouse model 1/n
tinyurl.com/vrfhttm5
Importantly, M5 positive allosteric modulation did not cause robust dyskinesia of its own, nor did it worsen L-DOPA-induced dyskinesia. Overall this suggests targeted M5 receptors modulation as a novel therapeutic target for PD. 5/n
Nicole Chambers, PhD retweeted
We are pleased to announce Dr. Mark Moehle, Ph.D., has been awarded ASPET's 2026 Division for Neuropharmacology Early Career Award! 🎉 Please join us in congratulating Dr. Moehle for this achievement!
Nicole Chambers, PhD retweeted
180+ neuroscientists & trainees from across US & abroad discussed latest research in Alzheimer’s, Parkinson’s, ALS, dementia @UF-hosted International Research Conference on Neurodegenerative Diseases July 9-12, co-sponsored by the MBI.
Learn more: bit.ly/3IqGzzq
Nicole Chambers, PhD retweeted
Pathological α-Synuclein Perturbs Nuclear Integrity biorxiv.org/content/10.1101/… #biorxiv_neursci
Nicole Chambers, PhD retweeted
Congratulations to our incredible @UF College of Medicine faculty recognized as outstanding or rising star researchers and mentors at the 15th Annual #UFMedResearch Celebration! Meet the winners: news.drgator.ufl.edu/2025/02…. #GoGators
Congrats, Mark!! Well deserved!
I’m excited to be among those in @LabMoehle who are presenting research at @UFMedicine Celebration of Research tonight from 5-7.
Incredibly honored to be awarded the Rising Star Award by @UFMedicine and @UFMedResearch. This would not be possible without all the wonderful people who work in the lab and the incredible environment at @UF_Pharmacology and @UFCTRND
Nicole Chambers, PhD retweeted
In this new preprint, Emily Twedell (PhD student) and colleagues identify a functional role for the inhibitory synapses between striatal projection neurons -- shaping striatal ensembles to promote healthy action selection. biorxiv.org/content/10.1101/…
If you’re still here at @SfNtweets, come and see posters from @LabMoehle !
This morning Iggy presents electrophysiological and cognitive changes in the PFF model of PD and this afternoon I will present electrophysiology and behavioral data from our Gnal linked dystonia mouse.
Nicole Chambers, PhD retweeted
Rick's dedication to curing dystonia is inspiring, and he will soon be a published expert in the disease that he and @TylersHope is dedicated to curing.
Nicole Chambers, PhD retweeted
New lab preprint from the outstanding postdoc @Nicholinergic! Here we report new exciting data from a model of GNAL linked #dystonia that we have created. Most importantly, this model shows overt dystonic motor phenotypes, a first for GNAL linked dystonia (1/N).
Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes biorxiv.org/cgi/content/shor… #biorxiv_neursci
Nicole Chambers, PhD retweeted
Today we present precise detection of endogenous opioids using genetically encoded biosensors. Multiple early variants have been validated in labs, and we have now optimized, determined, and benchmarked the first-gen opioid sensors for both in vitro and in vivo applications.
New paper out in @NatureNeuro!
Collaborating with several labs, we developed genetically encoded biosensors to track opioid pharmacology in the brain & provide powerful new tools for dissecting complex circuit-specific dynamics 🔧🧠
nature.com/articles/s41593-0…
