@NeuroVascuLab

Studying cerebrovascular disease at @CNIC_CARDIO, @MariAngelesMoro, @unicomplutense and i+12 - @neurodoce

 Madrid, Comunidad de Madrid
cnic.es/en/investigacion/neurovascular-pathophysiology
Joined June 2020
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Excited to share our new work by Jay Park @janghyun_park_ and friends! Jay found lymphoid structures in the skull bone marrow that seem to be serving immune hub role for the brain... brain, after all, may not be using "common lymph nodes" but rather has its own unique immune hubs and Jay showed their role in brain tumors... but their role in likely much more than that. This is a long paper but it is worth the read || nature.com/articles/s41586-0…

Functional role of skull lymphoid structures in CNS immunosurveillance

Nature - Functional lymphoid structures within the skull bone marrow enable central nervous system immunosurveillance and shape immune responses to brain disease.

nature.com
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Neurodegeneration as a dysregulation of neuroimmune crosstalk cell.com/cell/fulltext/S0092…

Neurodegeneration as a dysregulation of neuroimmune crosstalk

This perspective provides an overview of the growing literature on the role of the immune system in driving neurodegeneration and argues that restoring neuroimmune dialogue, rather than simply...

cell.com
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Dysregulated adult hippocampal neurogenesis in major depressive disorders | Nature Medicine nature.com/articles/s41591-0…

Dysregulated adult hippocampal neurogenesis in major depressive disorder

Nature Medicine - The largest multiomic atlas of the adult human hippocampus identifies disrupted neurogenesis, gene regulation and neural circuits in major depressive disorder, revealing molecular...

nature.com
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Oligodendrocyte dysfunction in human age-related cognitive decline nature.com/articles/s41591-0…

Oligodendrocyte dysfunction in human age-related cognitive decline

Nature Medicine - This study identifies oligodendrocytes as active contributors to cognitive decline in aging, by leveraging a unique human brain bank with more than 70 years of associated...

nature.com
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The brain struggles to make new neurons in people with depression | Nature nature.com/articles/d41586-0…

The brain struggles to make new neurons in people with depression

Nature - High resolution, wide-coverage map of the hippocampus reveals possible pathways for therapy.

nature.com
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NeuroVascuLab retweeted
CNIC@CNIC_CARDIOSep 4
2/3 The meeting is coordinated by ValentĂ­n Fuster (CNIC and Mount Sinai Fuster Heart Hospital), Costantino Iadecola (@WeillCornell), @mcortescanteli (@CNCajal_CSIC and @CNIC_CARDIO) and @MariAngelesMoro (CNIC).
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NeuroVascuLab retweeted
CNIC@CNIC_CARDIOSep 4
💡 Save the date! 🧠 On 20 November, @CNIC_CARDIO and @FundacionAreces will host in Madrid the 2nd edition of “Understanding the Neurovascular Network to Prevent Dementia”. Leading international experts will explore vascular health, cognitive decline and dementia prevention. More info: bit.ly/3SN5Uc7 #CNIC #Neurovascular #Dementia #BrainHealth
🤖 Made with AI
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Sequential clearance of neutrophil extracellular traps for precision therapy of sepsis science.org/doi/10.1126/scia…

Sequential clearance of neutrophil extracellular traps for precision therapy of sepsis

Sepsis, a life-threatening syndrome driven by dysregulated host response to infection, is critically exacerbated by the uncontrolled formation of neutrophil extracellular traps (NETs), which amplify...

science.org
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The Neurovascular Pathophysiology lab at @CNIC_CARDIO offers one of these #FPI PhD Student Fellowships. @MariAngelesMoro @neurovasculab. 👇🏼
Ministerio de Ciencia, InnovaciĂłn y Universidades
@CienciaGob5 Oct 2020
🚩 La @AgEInves convoca las Ayudas para contratos predoctorales para la formación de doctores 2020. Estas ayudas de 4 años permiten que investigadores en formación realicen su tesis doctoral en grupos de investigación. 🗓️ Del 13 al 27 de de octubre ➡️ bit.ly/3cZRFHD
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aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks science.org/doi/10.1126/scia…

aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue...

Human surgery and autopsy specimens are routinely stored as formalin-fixed paraffin-embedded (FFPE) tissue blocks for decades, creating vast archives of healthy and diseased tissues. While tissue...

science.org
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Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers science.org/doi/10.1126/scia…

Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers

Alzheimer’s disease (AD) develops silently for years before symptoms emerge, making early identification of at-risk individuals essential for prevention trials and early intervention. We tested...

science.org
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AhR inhibition promotes axon regeneration via a stress–growth switch nature.com/articles/s41586-0…

AhR inhibition promotes axon regeneration via a stress–growth switch

Nature - AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and...

nature.com
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Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human cell.com/cell/fulltext/S0092…?

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcript...

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in...

cell.com
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Blood-based circular RNAs for early diagnosis of Alzheimer’s disease nature.com/articles/s41591-0…

Blood-based circular RNAs for early diagnosis of Alzheimer’s disease

Nature Medicine - Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic AD, outperforming pTau217 and amyloid-PET.

nature.com
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Early detection of Alzheimer’s disease with circular RNA from blood nature.com/articles/s41591-0…

Early detection of Alzheimer’s disease with circular RNA from blood

Nature Medicine - Early diagnosis of Alzheimer’s disease is important to ensure timely and accurate treatment. We show that a blood-based circular RNA signature can accurately detect...

nature.com
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Engineering functional human vasculature: iPSC-derived vascular cells and organoids for disease modeling and translation sciencedirect.com/science/ar…
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A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know nature.com/articles/d41586-0…

A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know

Nature - Jaw-dropping patient videos and miraculous testimonials ignited a frenzy in China over a technique that aims to improve drainage from the brain. Now it is entering trials worldwide.

nature.com
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Unifying Terminology for Ischemic Core Size in Acute Stroke jamanetwork.com/journals/jam…

Unifying Terminology for Ischemic Core Size in Acute Stroke

This Viewpoint presents a new, unified terminology framework for ischemic core size in patients with acute stroke.

jamanetwork.com
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Microglia as integrators of brain-associated molecular patterns cell.com/trends/immunology/a…

Microglia as integrators of brain-associated molecular patterns

Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms...

cell.com
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