Senior Scientist I Microscopist & Manager, Live Imaging Facility I St. Vincent's AMR @SVHSydney #Neuralstemcells in #MultipleSclerosis, #KynureninePathway. Me.

Darlinghurst, Sydney
Joined November 2019
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.1101/… @Eric_Betzig @legant_lab
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Michael Lovelace, PhD retweeted
Can we predict future brain activity in a small vertebrate?🤔 We're releasing ZAPBench⚡️(#ICLR2025 spotlight): a benchmark to forecast activity in a whole vertebrate brain🧠 at single-cell resolution!🐟 70k+ neurons, 3 TB of data & extensive baselines. Connectome is coming! 🧵👇
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Michael Lovelace, PhD retweeted
#March Moments: Image of the Month 📆 🧠The beautiful intricacies of an electrified neuronal network captured on a @zeiss_micro Confocal microscope🔬 🥼Image by @barbaramsousa20 & Sandra Vieira from @ibimed_ua, @UnivAveiro 🇵🇹 @PPBioImaging #neurons #microscopy #sciart #bioart
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Michael Lovelace, PhD retweeted
Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By @janetiwasa
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Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
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Michael Lovelace, PhD retweeted
🔬 Transform your 3D imaging with Spheroid Clearing! Discover a cost-effective #protocol that enhances imaging depth & #resolution while preserving #morphology🧬 📄Access User Protocol 11: zurl.co/om6Dq 👨‍🔬By @_JulianHofmann_ from @TU_Muenchen #3Dimaging #Microscopy
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Michael Lovelace, PhD retweeted
Because #OpenScience cannot wait...🚀 Excited to share our latest preprint: 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔! 🔬 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔: a Versatile, Open-source EdU Multiplexing Methodology for Understanding DNA Replication and Cell Cycle Dynamics 💡 Affordable, efficient, and user-friendly, 𝐎𝐩𝐞𝐧𝐄𝐌𝐌𝐔 enhances EdU click chemistry staining with off-the-shelf reagents, enabling high-quality imaging across various cell types and complex 3D structures. 📊 Validated in multiple cell types, embryos, adult organs, hiPSC-derived organoids, and zebrafish larvae our work opens new avenues for understanding development, growth, and DNA replication. 🔗 biorxiv.org/content/10.1101/… #OpenEMMU #DNAReplication #CellCycle #OpenSourceScience #FluorescentImaging #FlowCytometry
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Buckle in, it is #microtubule cell migration story time! We reveal a new role for microtubules as cellular sensors which detect and respond to compressive forces, enabling movement and ensuring survival in mechanically demanding environments; just like this little guy squeezing through here. 1/10
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Michael Lovelace, PhD retweeted
PI3K dependent rearrangement of the actin cytoskeleton following the addition of Class I PAK kinase-inhibitor. Please read about it in our pre-print!
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Michael Lovelace, PhD retweeted
Incredible work by @_Akaash_Kumar, @JamesDManton, @DeriveryLab and many others. Their modular multispectral imaging concept allows to record simultaneously up to 8 channels at high frame rates. We're happy that our SPY probes could complement the FP based multi-organelle tagging! Below with SPY555-tubulin to label Microtubules 🤩! Congratulations to the whole team! doi.org/10.1101/2024.06.12.5…
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Wrapping up the week by visualizing the crazy axonal growth of dorsal root ganglia neurons in vitro using the SPY650-FastAct probe from @spirochrome! 🤩 Capturing one image every 10 minutes.
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Michael Lovelace, PhD retweeted
Access to EPI, HILO and TIRF illuminations with one click With Abbelight™ SAFE bioimaging platform, you can easily switch from one automatically preset optimal illumination mode to another. Learn more: abbelight.com/technique-tirf… #microscopy #TIRF
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Michael Lovelace, PhD retweeted
The new AI feature AiviaMotion combined with LIGHTNING helps you to capture fast subcellular dynamics with better image quality. 📰 Read the article and understand how AiviaMotion and LIGHTNING enhance signal-to-ratio and resolution. #Aivia #AiviaMotion #subcellardynamics

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Join us for “Technology across St Vincent’s Research Campus Precinct” with Dr. Jeffrey McArthur (@JRMcArthur17), Dr. Ira Deveson, Dr. XiaoSuo Wang, Dr. Venessa Chin (@Chin_Venessa) and Dr. Michael Lovelace (@NeuroStemLab). #SVCRS2021
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Michael Lovelace, PhD retweeted
Today @LeicaMicro and @EMBLEvents allowed me to present at @embl my ten-year journey across different countries and alongside amazing people: "From time-gated #STED to SPLIT-STED". #EMBLSuperResolution #BrightEyes_ERC #superresolution #singlephotonmicroscopy @IITalk @mpi_bpc
Michael Lovelace, PhD retweeted
The spike protein of SARS-CoV-2 interacts with cholesterol and ACE2 to induce viral entry and pathological cell-cell fusion. Can cholesterol-lowering statins be used as a treatment for COVID-19? elifesciences.org/articles/6…
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Michael Lovelace, PhD retweeted
⏰J-1 before the webinar⏰ Join @CaorsiV and @bcompans tomorrow at 3:30 pm CET to learn more about the new #SAFeRedSTORM and its use for synapse imaging through a talk and a demo. To register click here 👉eventbrite.fr/e/safe-redstor… #superresolutionmicroscopy #neuroscience
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Michael Lovelace, PhD retweeted
The powerhouse of our cells, mitochondria (green), and the genetic information in our cells, DNA (purple), videoed in a cancer cell with three nuclei using a microscope. #CellBiology #microscopy
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Michael Lovelace, PhD retweeted
Like much of 2020, we're going #virtual this year for @SVHSydney Research Week! Great chance to showcase the amazing work of clinical researchers in challenging times 💫
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Michael Lovelace, PhD retweeted
Come listen to my fellow AWS and myself explore the ins and outs of LAS X's Navigator. A great tool for navigating and imaging your samples! RSVP at go.leica-ms.com/NAVI #microscopy #imaging #webinar