Director, Pediatric Precision Oncology @ClevelandClinic, Physician-Scientist focused on immunotherapies for patients with brain tumors

Rajappa Lab, Cleveland Clinic
Joined October 2019
Operationalizing a precision oncology service line requires multi-disciplinary effort across the enterprise @ClevelandClinic Learn more about how we’re developing next generation personalized🔬🩺💻approaches-integrating AI, immuno-oncology & molecular diagnostics to inform care
Cancer treatment is becoming more personalized, especially for children and young adults with rare or hard-to-treat cancers. Molecular profiling helps doctors identify genetic changes in tumors that may lead to more targeted treatment options and better-informed care decisions. Learn more about how this approach is shaping pediatric cancer care: cle.clinic/4nn0fUY
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Congrats on this exceptional study! @JustinLathia @JuyeunLee31
Super proud of this work just out in @Nature - great thread from @JuyeunLee31 who now has her own lab at @CleveClinicFL 🕺
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Congrats on your work in advancing cardiovascular imaging @YaleMed !
Grateful to be part of the Yale Cardiology team—learning from incredible mentors and collaborating with curious, team‑driven colleagues. These experiences continue to shape how I approach research and patient care 💙💙💙
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Great lunch with Director @caseccc Dr. Gary Schwartz to discuss cross-campus collaboration to advance pediatric and young adult precision oncology initiatives @ClevelandClinic Excited for what’s to come next! 🧬🔬
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Great catchup with my friend and colleague Joe Costello @josephcostell14 @NeurosurgUCSF in the Bay Area last week 🌉⛵️☀️ Enjoyed talking collaboration in pediatric and young adult neuro-oncology and consortia for precision medicine 💪🏽 @ClevelandClinic #precisionmedicine
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Best part of @pmwcintl was the people! Always enjoy conversations and shared vision for next-generation precision oncology informed clinical trials with trailblazer @DrBetofMDPhD 🚀🧬🔬 @StanfordCancer @ClevelandClinic
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Honored to be an invited speaker at #PMWC2026 in Silicon Valley with leaders from academia & biotech pushing precision medicine forward! Thankful to represent @ClevelandClinic & share our approach to developing precision oncology programs for children & young adults 🧬💻🩺🧠
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Thrilled to have recently started as Director of Pediatric Precision Oncology @ClevelandClinic Honored to lead the initiative across the enterprise and advance precision diagnostics and targeted treatments for patients. Excited to work on this with @RabiHannaMD @GeneCollector
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Great way to close out the Early Investigator Retreat @NeuroOnc with my friend and colleague the one and only @JustinLathia talking about the importance of social media & online presence in academic medicine 📸 #SNO2025
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Amazing start to #SNO2025 at the Early Career Retreat! 🧠 Honored serving as faculty mentor with Susan Chang, Vinay Puduvalli & Milan Chheda, in guiding discussions on job searches, contract negotiations, and academic career development. Future of neuro-oncology is bright! 🌟
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Reflecting on a great meeting @faseb with exceptional scientific colleagues from across the 🌎 focused on ending 🛑 cancer amidst this amazing backdrop 🌇 Kudos to the organizers! @JustinLathia @VivianLiLab @stephaniema912
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Enjoyed presenting my lab’s work in targeting #MIF to prevent #glioma #malignant #progression in collaboration w/ the Bucala lab @Yale Look forward to discussions with the #MIF scientific community to develop novel #treatments 💉💊 for our patients in Neuro-Oncology 🧠🔬
Great #MIF meeting thus far! Exceptional science - now it is time for translation! MIF therapeutics are ready for prime time 🤩
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Proud of Alessandro & Matt representing the lab @sitcancer for modulating the CD74/MIF axis and elucidating the immunomodulatory role of trabectedin to ✋🛑 malignant transformation of glioma ❗️❕🧠🔬#SITC24 Strong work team 💪🏽
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Praj Rajappa M.D., M.S. retweeted
I'll say it again, the best part of #SITC2024 is the people @NeuroOncDoc @mwilli323 @SRamakrishna_MD @maraademartino and friends 😁 Thanks for hosting @AkoyaBio! – at Houston, TX
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Honored to serve on the faculty at the Meet the Experts Luncheon @sitcancer annual meeting #SITC24 Enjoyed moderating a lively table discussion with physicians and scientists dedicated to developing immunotherapies for cancer🔬🧫💪🏽 @JennGuerriero @DrBetofMDPhD @ErnstoffMarc
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Amazing statistics from The Department of Neurosurgery at the Ohio State University Wexner Medical Center Under the great leadership of Dr. Russ Lonser @NeurosurgeryOSU #Neurosurgery
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Enjoyed working with @HambardzumyanL1 @RRead_Lab on this manuscript @GenesDev on the dynamic and complex #glioma #tumor #microenvironment 🧠🧬🔬🧫
Along with @HambardzumyanL1 and @NeuroOncDoc, I'm proud to announce publication in @GenesDev of our co-authored joint review on updated insights into the glioma tumor microenvironment and discussion of novel therapeutic approaches to this deadly disease! genesdev.cshlp.org/content/e…
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Reflecting on an incredible @KeystoneSymp #meeting focused on targeting #myeloid #cells in the #TME Enjoyed connecting with the #myeloid #community and look forward to #future #collaboration and #discussion with @JudithVarner2 @JennGuerriero @TylerEMiller and more!
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