@NeochoritisLab

We have a strong focus on synthetic organic chemistry and the basic tool of our strategy are Multi-Component Reactions (MCRs). #neolab

 University of Crete
chemistry.uoc.gr/neochoritis/
Joined May 2022
  • Tweets62
  • Following145
  • Followers87
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochorJan 27
Multicomponent reactions as a molecular prism: simple inputs are refracted into rich molecular diversity across the chemical space! Nice idea for the cover of the thematic issue on MCRs beilstein-journals.org/bjoc/… @BeilsteinInst @NeochoritisLab #MCRs
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor1 Oct 2025
Can we learn a molecule how to hold still? Atropos and time are always interconnected, even from Greek mythology. A very nice MCR summit, with interesting chemistry here in olomouc, Czech republic
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor14 Jul 2025
🚨New paper out in Nature Communications! Scaffold hopping + MCR chemistry to design non-covalent molecular glues for the 14-3-3/ERα complex. A step forward in PPI-targeting drug discovery @University of SanFrancisco! @NeochoritisLab @NatureComms @UOC_gr nature.com/articles/s41467-0…

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Nature Communications - Molecular glues have great potential for drug discovery if they can be systematically discovered. Konstantinidou, et al describe a scaffold-hopping approach using...

nature.com
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor3 May 2025
How you evolve an imaging agent into a potent therapeutic? Thanks everybody for this fruiful collaboration! doi.org/10.1002/chem.2025015… @UOC_gr @NeochoritisLab @ChemEurope @ChemEurJ #MCRs
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor3 Apr 2025
Proxybinders! Glues and more!!! Tnx to the hard work of Marios and Michalis! @UOC_gr @NeochoritisLab #MCRs #helmedchem2025
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Neochoritis Lab retweeted
Chemistry Europe@ChemEurope24 Mar 2025
#EurJOC Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions (Constantinos G. Neochoritis and co-workers) @UOC_gr @kneochor @NeochoritisLab #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Diving into the Shielding Surfaces: Construction of Atropisomeric Axes via Multicomponent Reactions

We successfully designed and synthesized a diverse library of atropisomeric molecular systems using a scaffold hopping strategy based on the GBB-3CR. Structural and computational analyses revealed...

chemistry-europe.onlinelibrary.wiley.com
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor10 Mar 2025
How can we exploit CH-π interactions and shielding surfaces to tweak conformations of known scaffolds? Thanks everyone for this work! chemistry-europe.onlinelibra… @EurJOC @ChemEurope @NeochoritisLab @UOC_gr @ELIDEK_HFRI #MCRs #Neolab
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor17 Feb 2025
Interrupting the route of known reactions can lead to novel chemotypes. By installing the oxo and acid functionalities on the same carbon, interrupted Ugi and Passerini reactions were discovered! doi.org/10.1021/acs.orglett.… @NeochoritisLab @ELIDEK_HFRI @ACSPublications @JOC_OL #MCRs

Navigating Unexplored Territories of the Interrupted Ugi and Passerini Reactions toward Peptidomi...

Abstract. Interrupted reactions redirect established processes, often resulting in unexpected and novel outcomes. By employing a building block containing

pubs.acs.org
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor24 Jan 2025
C1 annulations are never outdated! Thanks everybody for this smart way of utilizing formamide in a sustainable way! 10.3762/bjoc.21.13 @NeochoritisLab @UOC_gr @EmpireikionIdryma #MCRs #Neolab
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Neochoritis Lab retweeted
Dinos Neochoritis@kneochor6 Nov 2024
Very glad to be hosted and present our work on MCRs at the National Hellenic Research Foundation!! @NeochoritisLab @ELIDEK_HFRI @UOC_gr #MCRs – at Attiki, Greece
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Let us share some moments from last week in the 23rd Panhellenic Chemistry Conference!
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We were very happy to be part of the 23rd Panhellenic Chemistry Conference, 2024. Our group thrived with 3 oral presentations, 2 flash poster presentations and 2 poster attendances. Looking forward to many more opportunities like this!
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We are obligated to inform you about the achievements of @UOC_gr in the 3rd day of PCC 2024! Congratulations to Prof. M. Orfanopoulos for being awarded for his lifelong achievements in organic chemistry. Also congratulations to Prof. G. Vassilikogiannakis for his amazing lecture!
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Where to find the members of our lab in the 23rd Panhellenic Chemistry Conference!
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The 23rd Panhellenic Chemistry Conference have just started! #neolab #chemistry #ath #PCC2024
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Not because she’s a member of our, but Paria Anastasiou just delivered a great Oral Communication at the EFMC-ISMC 2024! Congratulations! 🎉 @kneochor @EuroMedChem @UOC_gr #neolab #EFMCISMC24 #uoc
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The star of our lab is beginning her oral presentation! 💫
EFMC@EuroMedChem5 Sep 2024
📣 Session 26 – The last speaker of the session is Ms Paraskevi Kleio ANASTASIOU who will talk about “MCR-Based Lipidoids”. Keep following us! 🔬💡 #EFMCISMC24 #MedChem
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A round of applause to Marios Zingiridis from our lab for delivering a flash poster presentation and engaging in poster session at EFMC-ISMC 2024! @EuroMedChem @kneochor @MichelleArkin @mark_kons #EFMCISMC24 #neolab #Rome
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Day 3 of EFMC-ISMC 2024! We have started with a great presentation from a partner of our lab Prof. Luc Bunsveld! #EFMCISMC2024 #Rome #neolab
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High Rotational Barrier Atropisomers (Constantinos G. Neochoritis @kneochor and co-workers @NeochoritisLab at @Uoc.gr) #OpenAccess onlinelibrary.wiley.com/doi/…

High Rotational Barrier Atropisomers

An unprecedented class of atropisomers based on Ugi reaction that exhibit exceptional rotational barrier is reported. The versatility of our approach enables the synthesis of atropisomers “by...

chemistry-europe.onlinelibrary.wiley.com
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