lets help protect and support each other this is a really hard time for us all. Personal account / my views.
Australia
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1/ New preprint from the lab, led by Maria Bergamasco!
We've developed a way to deliver BDNF directly to the brain using nose drops. Weekly dosing rejuvenates an old mouse's brain and blocks memory loss in a mouse model of Alzheimer's disease.
doi.org/10.64898/2026.04.19.…
Greg Neely retweeted
An unexpected and potentially big finding:
A single mitochondrial protein has an outsized role, acting as a central node, coordinating our circadian clock, temperature, dietary cues, sleep/wake cycle to control brown fat metabolism @ScienceMagazine
science.org/doi/10.1126/scie…
Greg Neely retweeted
Nature has just published a pretty incredible paper.
The authors introduce a framework that turns research papers into interactive AI agents.
Rather than engaging with a paper only as static text, researchers can question its agent, ask it to reproduce an analysis, or apply the paper’s methods to new data.
This could make research methods much easier to understand, reproduce, and use.
It also opens up a strange possibility: research papers that can, in a sense, talk to one another. The authors demonstrate this by connecting agents derived from different papers so that they can combine their methods and data.
Used carefully (and with human scientific judgment still firmly in the loop) this could become a powerful new form of scientific communication.
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Full paper in the first reply
Sweet, our new paper out in Science Advances(Cover). Sea nettles sting millions of people every year and the best treatment we have is baking soda and seawater. We ran a whole-genome CRISPR screen to find how the venom targets us. doi.org/10.1126/sciadv.aec75… 1/9
New findings mark a potential use for heparin as a safe, accessible treatment to relieve people suffering from painful sea nettle stings.
Learn more in this week’s issue of Science Advances: scim.ag/4yhVyQN
ALT Atlantic sea nettle jellyfish pictured in the Texas State Aquarium. Sea nettle jellyfish sting millions of people every year, and though their venom is nonlethal, it can be toxic to the skin, heart, and other parts of the body. Using whole-genome CRISPR screening, Denes and D’Araujo et al. pinpointed which human genes and pathways effectively modify the action and effect of the venom. Genome screening found that heparin, an anticoagulant, can protect cells from sea nettle venom. The authors’ findings mark a potential use for heparin as a safe, accessible treatment to provide relief for people suffering from painful sea nettle stings. Credit: Gregory G. Dimijian / Science Source
In mice, venom in the footpad caused immediate spontaneous pain, heat hypersensitivity at 1 hour and mechanical pain out to 7 hours. Heparin given with the venom reduced all three. 8/9
Great work from co-first authors @amitsake and @anti_d4 , with Nicholas Casewell (@LSTMnews) and Eivind Undheim (@UniOslo). @CPC_usyd @Sydney_Science @Sydney_DDI
doi.org/10.1126/sciadv.aec75…
Greg Neely retweeted
1. Thrilled to announce our new preprint! A collaborative effort to sequence the bluebottle (Physalia utriculus) genome and decipher how this colonial organism's division of labour is driven by re-wired developmental programs rather than gene innovation 🧬🪼
Thread 🧵👇
Greg Neely retweeted
3. Together, we also characterize bluebottle venom and identify potential heparin-derived therapies to counteract stings 🩹
Thanks to all our collaborators! Read the full @bioRxivpreprint:
biorxiv.org/content/10.64898…
Greg Neely retweeted
Yet another study shows a 24% reduced risk of dementia after the Shingles vaccine. This one in over 500,000 participants with a recent skilled nursing facility stay, adding to 4 huge natural experiments in 4 countries (US, Canada, Wales, and Australia)
acpjournals.org/doi/10.7326/… @AnnalsofIM
Greg Neely retweeted
There hasn't previously been a treatment vs pancreatic cancer this successful. Striking improved (a > doubling) survival results @NEJM and @ASCO today with daraxonrasib, which also became available via an FDA approved early access program and began shipping to physicians this week @RevMedicines
nejm.org/doi/full/10.1056/NE…
9/ A paper out in ACS Nano from Yu, Deng and colleagues (Cheng, Teng, Wei labs) shows the same general approach works in a different disease setting. Two independent groups, different disease models, same conclusion: intranasal mRNA-LNP of neurotrophic factors works.