@Nazish_Sayed

Associate Professor @StanfordCVI @stanfordvasc @StanfordSurgery interested in #Endothelial & #Vascular Biology, #CardioOncology, and Reg Med. #Cancer survivor

 Stanford, CA
profiles.stanford.edu/nazish-sayed
Joined February 2015
  • Tweets417
  • Following279
  • Followers749
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Excited 2 share our new paper @ScienceTM. V show how a cancer drug disrupts blood-vessel #mechanosensing via #PIEZO1, driving #hypertension & #cardiac dysfunction & how restoring #endothelial function protects🫀 @Joseph_C_Wu @maryhawn @StanfordSurgery science.org/doi/10.1126/scit…

Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion...

PIEZO1 restoration protects against tyrosine kinase inhibitor–induced endothelial dysfunction, hypertension, and cardiac injury.

science.org
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Nazish Sayed MD, MS, PhD retweeted
Stanford CVI@StanfordCVIAug 12
When Blood Vessels Trigger Heart Failure Researchers at CVI have identified a new mechanism driving LMNA cardiomyopathy: endothelial cells undergo a dramatic identity change that promotes cardiac fibrosis and dysfunction. @Nazish_Sayed Read more here: med.stanford.edu/cvi/mission…
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Folks, our new study in European Heart Journal @ESC_Journals @ehj_ed RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy academic.oup.com/eurheartj/a… Team effort @StanfordCVI @StanfordSurgery @StanfordVasc @stanfordctsurg

RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy

AbstractBackground and Aims. LMNA-related dilated cardiomyopathy (LMNA-DCM) is a progressive genetic disorder characterized by conduction disease, malignan

academic.oup.com
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Nazish Sayed MD, MS, PhD retweeted
Science Translational Medicine@ScienceTMJan 1
The ion channel protein #PIEZO1 protects against cardiac injury during #cancer treatment with tyrosine kinase inhibitor #TKI #sunitinib, according to a new study in mice and patient-derived #endothelial cells. @StanfordMed scim.ag/4pGBFPv
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Excited 2 start 2026 with a review in @VMJ_SVM on #iPSC based #NAMs (#Vascular #Organoids, #multiomics) for rare vascular disease. Thx 2 Lu Liu David Wu PhilTsao @NickLeeper78 for Collab & @Joseph_C_Wu @maryhawn @StanfordSurgery 4 support. #RareDisease journals.sagepub.com/doi/10.….

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new...

Rare vascular diseases are a diverse group of life-threatening conditions defined by their low prevalence but profound impact on patient morbidity and quality o...

journals.sagepub.com
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Nazish Sayed MD, MS, PhD retweeted
Stem Cell Podcast
@stemcellpodcast29 Dec 2025
#Sunitinib is an effective cancer treatment, but exposure can result in #hypertension & #HeartFailure. Dr. @Nazish_Sayed's lab at @StanfordCVI restored #PIEZO1 expression to reverse sunitinib-induced #endothelial dysfunction. 🔖 bit.ly/4s9xrBG 🗨️ bit.ly/4pOTLib
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Nazish Sayed MD, MS, PhD retweeted
Endothelial Cell News
@endothelialnews18 Dec 2025
In this new @ScienceTM study from the lab of Dr. @Nazish_Sayed at @StanfordCVI, researchers identify a role for PIEZO1, a mechanically activated ion channel, in tyrosine kinase inhibitor-induced #cardiotoxicity and present a potential avenue for prevention. 🔗 bit.ly/4s9xrBG
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Nazish Sayed MD, MS, PhD retweeted
Stanford CVI@StanfordCVI17 Dec 2025
When life-saving cancer drugs put the heart at risk New research from @stanfordcvi reveals how TKI sunitinib disrupts blood vessels’ ability to sense blood flow, driving hypertension & heart damage. Read more: med.stanford.edu/cvi//missio… @Nazish_Sayed, @StanfordSurgery, @ScienceTM
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Thx to collaborators @amitmanhas07, Yu Liu, Noishiki, David Wu, Tripathi, Sarah Mirza, @iDilipThomas, Lu Liu, @avirupguha , Nguyen, Chen, Chitalia, Cheng, @dannysayed, @melindatelli, Karim Sallam, @Joseph_C_Wu Thx @Amanda_J_Chase for this amazing write up. cvi.stanford.edu/mission/new…
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Nazish Sayed MD, MS, PhD retweeted
Stanford Vascular@StanfordVasc22 Oct 2025
Baszucki Research Day 2025 ✨ We welcomed Dr. Ulf Hedin from Karolinska Institute as our Baszucki Visiting Professor. From dinner with faculty & residents to a keynote on precision medicine, Biobank tour, & Grand Rounds on biobanking—what a week of innovation & collaboration! 🔬
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Nazish Sayed MD, MS, PhD retweeted
Stanford Vascular@StanfordVasc17 Oct 2025
Stanford researchers led by Drs. @NickLeeper78, @Nazish_Sayed, & @EriFukayaMD have developed an induced pluripotent stem cell (iPSC) line from a patient with varicose veins — paving the way for in vitro modeling of venous disease. 🔗: brnw.ch/21wWImM
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Sharing our recent review @JMCCardiology We discuss how #LongCOVID drives cardiovascular complications & highlight the promise of #NAMs, #iPSC, #organoids & #AI in advancing diagnostics & therapies. @iDilipThomas @Joseph_C_Wu @StanfordCVI @StanfordSurgery jmcc-online.com/article/S002…
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Came home to this beautiful surprise — truly touched by the kindness and support 🌸 Grateful to @StanfordVasc @StanfordSurgery @StanfordCVI @maryhawn @Joseph_C_Wu @RLDalmanMD for supporting this promotion! Thx #Sayed Lab and friends @iDilipThomas @amitmanhas07 @chun_liu_86
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Nazish Sayed MD, MS, PhD retweeted
Stanford Vascular@StanfordVasc9 May 2025
🧬 iPSCs shed light on vascular Ehlers-Danlos syndrome—Dr. Lu Liu brings new insights from endothelial cell modeling. @Nazish_Sayed #Holman25
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Thank you @CircAHA for highlighting our recent paper on LMNA-related Dilated Cardiomyopathy. Need more studies that repurpose already FDA approved drugs for existing cardiac diseases @StanfordCVI @StanfordSurgery @SeanM_Wu @Joseph_C_Wu @josephahill @heshamasadek @American_Heart
Circulation@CircAHA7 Apr 2025
Olmesartan may provide targeted, mutation-specific therapy for HF patients with an LMNA mutation @SeanM_Wu @Nazish_Sayed @SJovinge ahajournals.org/doi/full/10.…
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"Teaching old drugs new tricks! Folks, our paper in @CircAHA explores repurposing olmesartan for LMNA-DCM using #iPSC-derived CMs and leveraging NIH funded @LINCSProgram data. @Joseph_C_Wu @SeanM_Wu @chun_liu_86 @maryhawn ahajournals.org/doi/10.1161/…

Olmesartan Restores LMNA Function in Haploinsufficient Cardiomyocytes | Circulation

BACKGROUND: Gene mutations are responsible for a sizeable proportion of cases of heart failure. However, the number of patients with any specific mutation is small. Repositioning of existing US Food...

ahajournals.org
Stanford CVI@StanfordCVI2 Apr 2025
Congrats 🥂 to @StanfordCVI researcher @Nazish_Sayed on a @CircAHA paper identify a #DrugRepurposing candidate for treating heart disease, found by analyzing gene expression in diseased hearts med.stanford.edu/cvi/mission… @StanfordMed @StanfordSurgery @StanfordVasc @StanfordDeptMed

Using Gene Activity Analysis to Repurpose Existing Drugs for Genetic Heart Disease

med.stanford.edu
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Great lab and great mentor.
Liya Yin, MD, PhD @UAZ Medicine-Phoenix@yly991292 Nov 2024
Yin lab is recruiting for positions at the University of Arizona, College of Medicine, Phoenix. If you’re interested in coronary microcirculation in diabetes and Heart Failure, please join us! Researcher/Scientist - arizona.csod.com/ux/ats/care… Postdoc - arizona.csod.com/ux/ats/care…
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🏆 Congratulations to Dr. Mary Hawn (@maryhawn) of @StanfordSurgery, who will receive the 2024 Wangensteen Scientific Forum Award at #ACSCC24 this weekend! Learn more about Dr. Hawn's academic leadership and prolific scientific research. brnw.ch/21wNLt7
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Nazish Sayed MD, MS, PhD retweeted
Nature Cardiovascular Research@NatureCVR15 Oct 2024
Research| Thomas, Noishiki et al. use thrombotic vascular tissues and cardiac organoids to show that COVID-19-induced endotheliitis and cytokine release disrupt #endothelial-cardiomyocyte crosstalk and contribute to cardiac dysfunction in #longCOVID. 👉rdcu.be/dW3Tr
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Endotheliitis... Not your friend. @resiapretorius @PutrinoLab @dbkell @doctorasadkhan @DrGrahamLJ Excellent paper💪🏻 Thank you, Nazish 🙏🏻🙏🏻
Nazish Sayed MD, MS, PhD@Nazish_Sayed14 Oct 2024
Our paper on endothelial - cardiomyocyte crosstalk in #LongCovid is now online @NatureCVR. It highlighting the importance of early vascular health monitoring in patients with #LongCovid. @iDilipThomas @StanfordCVI @StanfordSurgery @maryhawn @StanfordVasc nature.com/articles/s44161-0…
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