NIH RM1 BTOD Center advancing scientific instrumentation and computational tools in collaboration with biomedical researchers across the nation.
The Ohio State University, Columbus, OH
Joined October 2018
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@OSU_CBC lab named national Resource for Native Mass Spectrometry Guided Structural Biology. #ASCDaily go.osu.edu/Cbk3
Native MS-Guided Structural Biology Center retweeted
Join @thermofisher and @NativeMassSpec on January 16 to highlight the complementarity of native mass spectrometry and cryoEM 🎉
To register, visit forms.office.com/Pages/Respo…
Native MS-Guided Structural Biology Center retweeted
Check out our latest paper 📚🔬 on predicting collision cross section (CCS) from protein structures through a user-friendly, free-to-use webserver, ROSIE-PARCS. We hope ROSIE-PARCS can help mass spectrometrists with their CCS predictions!
doi.org/10.1093/bib/bbad308
Native MS-Guided Structural Biology Center retweeted
Breaking a big problem into smaller pieces and solving them one by one is a good strategy for designing a protein (and navigating life in general). Check out the @biorxivpreprint where we apply this idea to designing pseudosymmetric hetero-oligomers!
biorxiv.org/content/10.1101/…
Native MS-Guided Structural Biology Center retweeted
In this paper, we pseudosymmetrized two de novo designed homo-oligomers. For the first, BGL0 (pronounced “bagel zero”), we worked worked with @NativeMassSpec and @SibylsSAXS to verify that 10 of the 20 redesigned homotrimers assemble properly
Webinar: Native Mass Spectrometry for Structural Biology via @ProteinSociety mailchi.mp/proteinsociety/jo…
Native MS-Guided Structural Biology Center retweeted
It's out!
Intrinsically disordered interaction network in an RNA chaperone revealed by native mass spectrometry | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.22…
Native MS-Guided Structural Biology Center retweeted
Excited to share our latest cooperativity story. We quantified the ligand binding cooperativity in cyclic homo-oligomers via Native MS and mechanistic modeling. One of the proteins has about 30 times higher cooperativity than hemoglobin! @NativeMassSpec @OSU_CBC
Native MS-Guided Structural Biology Center retweeted
Excited to work on this collaboration with @BHIVE_Center and @NativeMassSpec
Sophie Harvey, PhD @SophsHarvey, Research Scientist @OhioState Univ., Dept. of Chemistry and Biochemistry @OSU_CBC. Dr. Harvey will use native mass spectrometry to characterize the interactions of the HIV-1 capsid protein with small molecule antivirals.
ALT Professional Headshot of Dr. Sophie Harvey
Native MS-Guided Structural Biology Center retweeted
Give our new MASH Native page a follow for exciting updates to our FREE MS processing software that can process ALL types of native MS data!
Native MS-Guided Structural Biology Center retweeted
Now available in Nature Communications: our most recent work using ion mobility mass spec data to elucidate protein tertiary structure. Exciting collaboration with @WysockiVicki and the Prell Lab. @NativeMassSpec
nature.com/articles/s41467-0…
Native MS-Guided Structural Biology Center retweeted
Our most recent SID modeling work is now out. In a collaboration with the @WysockiVicki Lab, we use structures of protein complexes to predict SID breakage profiles. The new method is available in Rosetta. @NativeMassSpec
pubs.acs.org/doi/10.1021/acs…
Native MS-Guided Structural Biology Center retweeted
I really enjoyed being a part of this collaboration between the @woodson_lab and @NativeMassSpec where we used native MS with IM-SID to better understand the role of intrinsically disordered C-terminal domains in the multimeric RNA-binding protein Hfq. biorxiv.org/content/10.1101/…
Check out these Resource presentations by the Wysocki group and Russell group at ASMS 2022 nativems.osu.edu/node/505
Native MS-Guided Structural Biology Center retweeted
Congrats to @KostelicMarius and Jason for their new paper in @J_ASMS! They discovered that PEG coating improve sensitivity of native MS, especially of AAV capsids. Awesome work from the team @ErinBakerNCSU @Aspinwall_UA @J_Ryan33 @henrymsandersg1!
pubs.acs.org/doi/full/10.102…
Native MS-Guided Structural Biology Center retweeted
Exciting collaboration where we show that HRPF-guided Rosetta structure elucidation is successful in a true blind prediction scenario.
In their work, @JoshuaSSharp @UM_glycore @LindertLab @rjdoerksenmass show how a spectrometry-based method guides computational modeling for de novo protein structure prediction.
nature.com/articles/s42003-0…
Native MS-Guided Structural Biology Center retweeted
Our review article in @AnnualReviews of Physical Chemistry is out! We are summarizing computational work that is using mass spectrometry data for protein structure determination. With particular focus on chemical cross-linking, HDX, HRPF, IM, and SID.
annualreviews.org/doi/10.114…
Interested in learning how Native MS can help answer structural biology questions? A two-day short course in Native Mass Spectrometry, to be held June 4-5 at ASMS in Minneapolis, is designed to introduce this growing field to new practitioners. asms.org/conferences/annual-…
Native MS-Guided Structural Biology Center retweeted
New UniDec version 5.0.3 ready to release in the wild. The most interesting new features are the real time deconvolution experimental features (short thread) and the m/z vs. mass plot for CDMS
github.com/michaelmarty/UniD…
Native MS-Guided Structural Biology Center retweeted
The MASH Team is excited to announce the first version of MASH Native! MASH Native builds upon previous versions of MASH Explorer but also includes new features such as spectral summing, internal fragments, and Unidec deconvolution. Check it out today at: labs.wisc.edu/gelab/MASH_Exp…
Protein Quaternary Structures in Solution are a Mixture of Multiple forms biorxiv.org/content/10.1101/…