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Modulating networks using DBS is an effective treatment for PD – but which circuits map to improvements in individual symptoms such as tremor, bradykinesia, rigidity, and axial? A 🧵 about our new paper out now in @NatureComms doi.org/10.1038/s41467-024-4… @netstim_org
As per usual, the stim brains line up is beyond exciting!! 🫡Looking forward to it!!
Curious about how to get a job in academia? 👩🎓or the latest in neuromodulation for epilepsy? ⚡️🧠
Join us on 21st Nov at 12 PM ET/ 6 PM CET to learn more!
Ft. Robert Fisher and our very own @fredschaper_
Register here to attend: partners.zoom.us/webinar/reg…
Congratulations!! well deserved and can't wait to see you here!
Congratulations to @b_hollunder for getting a Thiemann Fellowship to join @foxmdphd at the @Brain_Circuits next year! Couldn’t be more proud and this is so well deserved after a truly fantastic PhD! 🙌👏🎉🎉🥳🎈🎁
Nanditha Rajamani retweeted
Tune in to the new @stimbrains episode with none else than @SuthanaLab here 👇👇
We had a wonderful, inspiring and insightful conversation with @SuthanaLab on memory, PTSD, virtual reality, neural recordings in freely moving participants, as well as the future of neuromodulation!
Tune in here 👇👇
stimulatingbrains.org/60-dr-…
Episode produced by @niels_pacheco🙏
Really looking forward to this!!
🎙️ Just 2 days to go! Join us for an insightful talk from @ArynGittis and @drpouratian. Don’t miss the chance to dive deep into the latest and greatest in optogenetics and pallidal burst stimulation. 📅 October 31st 🕒 12 PM ET/5 PM CET 🖥️ Register now 👉 partners.zoom.us/webinar/reg…
Nanditha Rajamani retweeted
🚨 The talk series is back from its summer break 🚨
Join us on Thursday, October 31st 12 PM ET/ 5 PM CET for a discussion on optogenetically inspired pallidal burst stimulation w/ Nader Pouratian and Aryn Gittis 🧠⚡️
Register here 👇👇👇
partners.zoom.us/webinar/reg…
Nanditha Rajamani retweeted
Taking the art of Dr. Rhoton to the next level of 3D using photogrammetry of dissections for DBS targets! The full atlas can be freely accessed at: skfb.ly/prFID
Congratulations Bahne & team!! ⚡️🧠
🚨🥁Preprint alert: #DBS Programming is currently a tedious trial and error process that involves testing many settings – each time asking the patient to perform motor tasks to see how things improve. Could we use DBS-#evokedpotentials to guide programming?doi.org/10.1101/2024.10.04.2…
Nanditha Rajamani retweeted
🚨🥁Preprint alert: #DBS Programming is currently a tedious trial and error process that involves testing many settings – each time asking the patient to perform motor tasks to see how things improve. Could we use DBS-#evokedpotentials to guide programming?doi.org/10.1101/2024.10.04.2…
Fantastic paper and nice tweetorial - good evidence to show that early-stage DBS might slow motor symptom progression! Read this fantastic work from @MalloryHacker et al. link.springer.com/article/10…. Thank you for including me!!
I am super excited by this figure just published by @MalloryHacker et al. – why?
Let’s unpack… 🧵
link.springer.com/article/10…
Nanditha Rajamani retweeted
I am super excited by this figure just published by @MalloryHacker et al. – why?
Let’s unpack… 🧵
link.springer.com/article/10…
Thanks for the great opportunity @GreenJournal podcast and @DrJeffRatliff! Please tune in to listen about our recent work! 🎧🎙️
Excited to discuss @NaN_Value’s recent @NatureComms paper on DBS for Symptom-Specific Networks in Parkinson Disease on the @GreenJournal podcast – thanks @DrJeffRatliff for the kind interview and fantastic questions!
🎧🎧 Episode available here: youtube.com/watch?v=dPir7Ptx…
Nanditha Rajamani retweeted
Out @NatureNeuro: Network localization of brain stim targets for PTSD.
TLDR: Lesions connected to this circuit REDUCE risk of PTSD in Vets. Also tested with fMRI and TMS.
Free link: rdcu.be/dUVTY
With @foxmdphd @NoahSPhilipMD @davidcarreon @AArulpragasam @MoreyLab
Nanditha Rajamani retweeted
Can we use DBS evoked potentials to guide programming? @bahnebahners presenting @DBSThinkTank suggests we’re getting close! @netstim_org @Brain_Circuits
Nanditha Rajamani retweeted
Thank you for the kind editorial @garance_meyer & @DrPhilipMosley on our blinded replication study with @SameerShethMD @RonGadot @NingfeiL et al.
A “promising intermediate step between retrospective studies and prospective validation of the tract”
authors.elsevier.com/a/1jJXa…
Nanditha Rajamani retweeted
Excited about a collaboration out at @CommsBio with the stroke team at @ChariteBerlin – @IdaRangus, @sofiari91 & @anna_kuf et al.
What they did:
Analysis of *thalamic* stroke sites that led to aphasia.
There are two distinct take homes:
A mini-🧵
nature.com/articles/s42003-0…
Nanditha Rajamani retweeted
A study co-authored by #MassGeneral physician @andreashorn_ MD was covered by @ScienceDaily. The study developed a deep brain stimulation algorithm that may help personalize the treatment of Parkinson's disease. sciencedaily.com/releases/20…
25/n We presented and validated across 3 cohorts, a symptom-response tract library for four cardinal symptoms of PD— tremor, bradykinesia, rigidity and axial symptoms. Finally, we developed and tested an algorithm capable of optimizing symptom profiles in patients with STN-DBS.
26/n As a side note but also very importantly! our reviewer comments along with several validation results lead to supplementary material with 36 figures! Oof! Special thanks to @HelenFriedrich_ @c_neudorfer and the twitterless Konstantin Butenko for making this possible.























