@NMoraisLab

Disease Transcriptomics Lab, led by Nuno Barbosa-Morais, at @nova_medschool. bsky: https://xitter.cf/t.co/Y8diqURbgS

 Lisbon, Portugal
diseasetranscriptomicslab.github.io/
Joined August 2017
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93Media
🧬 From Data to Discovery! On 9 October, BIOMICS welcomed @emblebi experts to @GIMM_Institute for @uniprot training (15 participants), a Biomedical Data Science Seminar & a new @BiomicsTwinning Friends interview! 🎥 #BIOMICS #UniProt #Bioinformatics
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Thanks to the support of @BiomicsTwinning and @EMBO_YIP, Nuno is now a Certified Night Science Trainer, after attending the wonderful “train the trainer” event at @EMBL Heidelberg last week, led by the two and only @ItaiYanai and @MartinJLercher.
Itai Yanai
@ItaiYanaiOct 2
This week we held our second-ever “train the trainer” event in Heidelberg at EMBO/EMBL to pass on our teachings on the creative scientific process to 50 instructors. We're on our way to achieving our mission of bringing creativity training to all scientists worldwide!
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He looks forward to not only bring creativity training to Portugal but also incorporate some of the concepts in his Critical Thinking teaching, which also covers Day Science.
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New preprint 📢! We analysed stress granule transcriptomes and found differential centrifugation is strongly biased by RNA length. Correcting for this erases most reported overlap. Mitochondrial RNAs remain as a modest signal, hinting at immune signalling. doi.org/10.64898/2026.09.08.…
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When the PI’s away, the Lab will happily and productively play. 🙂
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Farewell and welcome: Marta Bica 🇵🇹(PhD alumna, 2018–2026) moves to Botton-Champalimaud Pancreatic Cancer Centre as a single-cell/spatial transcriptomics expert, while Alessandro Minguzzi 🇮🇹joins today, becoming a PhD student in Sept, studying CDKN2A in cancer. #Alumni #PhD
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Garbage In, Plot Out 🧠 A bioinformatics pipeline will always give you something: a plot, a p-value, a cluster. It won’t tell you whether the parameters you chose were the right ones. That’s the black box problem in bioinformatics📊. A thread on why critical thinking matters 🧵
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(3/4) Same story in alternative splicing. A gene either “looks” differentially spliced or it doesn’t, depending on the threshold you pick. betAS models each PSI estimate with a beta distribution, so the uncertainty behind it is visible.
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(4/4) Software can expose assumptions, but interpreting them is still on us. That scrutiny is what @BiomicsTwinning , our Horizon Europe project, aims to instil in the next generation of researchers. Explore our tools 🧬diseasetranscriptomicslab.gi… #OpenScience #CriticalThinking

Disease Transcriptomics Lab · NMorais Lab

Decoding transcriptomes to understand disease. Computational biology research at NOVA Medical School, Lisbon.

diseasetranscriptomicslab.github.io
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🚀 Our new research lab website is now live! After a few months of moving, settling in, and rebuilding, the Disease Transcriptomics Lab is now online: diseasetranscriptomicslab.gi… Find out more about our research, tools, people, ethos, and opportunities to join us.

Disease Transcriptomics Lab · NMorais Lab

Decoding transcriptomes to understand disease. Computational biology research at NOVA Medical School, Lisbon.

diseasetranscriptomicslab.github.io
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NMorais Lab retweeted
Rafael Irizarry@rafalabJun 17
Congratulations to the R Core Team on receiving the 2026 Rousseeuw Prize for Statistics. For over 30 years, R Core has maintained one of the most important pieces of infrastructure in statistics. Little recognition, thousands of volunteer hours, and enormous impact. Thank you!
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NOVA Biomedical Research (NBR) is a program for those who want to discover, question, and advance science. 1/4
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Finally out, a much improved peer-reviewed article published in NAR Genomics & Bioinformatics @OUPAcademic. 👏 @ritamtbs and @AKaizeler! academic.oup.com/nargab/arti…

Exploring molecular signatures of senescence with marker, an R Toolkit for evaluating gene sets as...

Abstract. Many biological processes, including cellular senescence, manifest as diverse phenotypes across cell types and conditions. Lacking definitive mar

academic.oup.com
NMorais Lab@NMoraisLab11 Dec 2025
Following the @Bioconductor package, the @biorxivpreprint preprint: "Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers". 💻🧬📰 👏 @ritamtbs 💪 biorxiv.org/content/10.64898…

Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as...

Many biological processes, including cellular senescence, manifest as diverse phenotypes that vary across cell types and conditions. In the absence of single, definitive markers, researchers often...

biorxiv.org
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🎥 NEW Getting to know BIOMICS Members episode! Meet @mirimiam from @CRGenomica, sharing his scientific journey, perspectives on collaboration, and research in evolutionary medical genomics. 📺 youtu.be/T5ZpgSiowY8 #BIOMICS #HorizonEurope #Genomics #BiomedicalScience
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🚀 Today’s #BIOMICS course at @GIMM_Institute: A packed room exploring probabilistic #model #building, #Bayesian thinking, #AI, diffusion models, and active learning 🧠 Fantastic discussions and engagement throughout the day! #BIOMICS #DataScience #MachineLearning #HorizonEurope
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🚨 Now at @GIMM_Institute, Mafalda Dias & Jonathan Frazer, from @CRGenomica talking about how we can read #evolutionary constraints with #deep #learning. #EUfunded #BIOMICS #EvoMG
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Happening now 🚨 BIOMICS Seminar by Manuel Irimia on “Evolutionary landscapes of zygotic genome activation across animals” 📍 In-person at GIMM Lisboa + live on Zoom #BIOMICS #Seminar #Genomics
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The Lab was well represented at the Bioinformatics Open Days @UMinho_Oficial, with Nuno giving a keynote lecture and @AKaizeler, @francisca_xb, and @ritamtbs presenting posters.
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@UMinho_Oficial @AKaizeler @francisca_xb @ritamtbs
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