Montserrat Muñoz Mateu

Normal breast tissues harbour rare populations of aneuploid epithelial cells Study used single-cell DNA sequencing to analyze 83,206 epithelial cells from the breast tissues of 49 healthy women and found that rare aneuploid epithelial cells, which carry abnormal numbers of chromosomes, are present in all women (median 3.19%), with their prevalence increasing with age. Many of these cells (median 82.22%) exhibited clonal expansions and harbored copy number alterations similar to those seen in invasive breast cancers, such as gains of 1q and losses of 10q, 16q, and 22q. The aneuploid cells were primarily associated with luminal epithelial lineages and localized in ductal and lobular structures without any apparent histopathological abnormalities. These findings suggest that clonal expansions of aneuploid cells are a normal feature of healthy breast tissues. #BreastCancer @YiyunLin_YL @junkewang @KaileWang @SohrabShah @sajraparicio @ThennavanAatish @ACasasent @WinocourMD @nicholas_navin #OncoAlertAF @nataliagandur @acampsmalea @BiagioRicciutMD @yekeduz_emre @HHorinouchi @FadiHaddad_MD @Dr_Ivanoncologo @Abdallah81MD @FernandoOnco @ElisaAgostinett @to_be_elizabeth @lungoncdoc @bavilima @realbowtiedoc @Erman_Akkus @DrFMartinelli @Lucarecco @heinrich_kat @niklas_kluemper @matteolambe buff.ly/3V1rbwT