@MundlosLab

Bio - logy. Mutations, TADs, and gene regulation in development. All the good stuff. Tweets by @mphan_236 and lab members.

 Berlin, Germany
molgen.mpg.de/147323/Development-and-Disease
Joined January 2015
  • Tweets130
  • Following206
  • Followers1.8K
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(1) Chromatin/cancer paper alert! We've unraveled how genotoxic anticancer drug impacts the chromatin structure of human cells. Using Hi-C, ChIP-seq, and RNA-seq, we've explored the changes in chromatin architecture triggered by doxorubicin and ICRF193. mdpi.com/2073-4409/12/15/200…

Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters

In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq,...

mdpi.com
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Excited to share our story on how enhancers repositioning leads to disease-associated gene mis-expression during development out in @NatureComms 🧬🐁🤓 I couldn't be happier to have teamed up with @Giulia_Cova on this one! @MundlosLab 👇 rdcu.be/c73nV
Giulia Cova@Giulia_Cova20 Mar 2023
And it’s officially out @NatureComms!!Couldn’t be happier 😃🥳!! A long way, but definitely worthy!!Thanks to my amazing partner-in-crime @GJuliane_ 🤗, all the authors, the reviewers, and to everyone that has been part of this journey 🤗 so grateful!! nature.com/articles/s41467-0…
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And it’s officially out @NatureComms!!Couldn’t be happier 😃🥳!! A long way, but definitely worthy!!Thanks to my amazing partner-in-crime @GJuliane_ 🤗, all the authors, the reviewers, and to everyone that has been part of this journey 🤗 so grateful!! nature.com/articles/s41467-0…
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🧬 Want to dissect the gene regulatory function of long non-coding RNAs using #genomicengineering #syntheticbiology? Join the lab of @StefanMundlos / @MundlosLab & our #IMPRS-BAC #gradschool! Apply today! 👉 molgen.mpg.de/4567460/Mundlo…
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Researchers @MeloUira @StefanMundlos @MundlosLab @VingronLab characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements and investigate their impact on gene expression and the 3D chromatin architecture. go.nature.com/3VgGeAM
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🦔 Looking for a #PhD position & interested in investigating how the hedgehog got its spines? Join the lab of @StefanMundlos / @MundlosLab & our #IMPRS-BAC #gradschool! Apply today! 👉 molgen.mpg.de/4567427/Mundlo…
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We are happy to share the latest work from @MundlosLab published on @NatureComms We combined short- and long-read sequencing in samples with germline complex genomic rearrangements. doi.org/10.1038/s41467-022-3…

Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline...

Nature Communications - Here the authors characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements, identifying breakpoints by employing short- and...

nature.com
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Interested in gene regulation in disease? Stay tuned for @mrmikerobson1´s lab opening @BIMSB_MDC in April 2023.
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Job alert Postdoc: you are a molecular biologist and interested in gene regulation? Study how lncRNAs work in regulating genes in development. Use cutting edge technologies including synthetic genomics and large-scale genomic engineering. Contact me. molgen.mpg.de/Development-an…
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Thanks so much to everybody for support in this #ERCAdG endeavor! It has been a tough competition. I see it as a special honor that my project was viewed as "ostentatiously overambitious" by a reviewer. Peer reviews are so much fun! 😂
MPI for Molecular Genetics@MPI_MolGen26 Apr 2022
🍾 Congratulations! 🎉 For a a research project on the genomics of evolution, or “how bats learned to fly”, our researcher @StefanMundlos / @MundlosLab has been awarded a prestigious @ERC_Research Advanced Grant #ERCAdG molgen.mpg.de/4491702/

Stefan Mundlos receives an Advanced Grant from the European Research Council

Berlin researcher Stefan Mundlos has been awarded a prestigious ERC Advanced Grant. The funding program of the European Research Council (ERC) is one of the most distinguished in Europe. Mundlos...

molgen.mpg.de
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🍾 Congratulations! 🎉 For a a research project on the genomics of evolution, or “how bats learned to fly”, our researcher @StefanMundlos / @MundlosLab has been awarded a prestigious @ERC_Research Advanced Grant #ERCAdG molgen.mpg.de/4491702/

Stefan Mundlos receives an Advanced Grant from the European Research Council

Berlin researcher Stefan Mundlos has been awarded a prestigious ERC Advanced Grant. The funding program of the European Research Council (ERC) is one of the most distinguished in Europe. Mundlos...

molgen.mpg.de
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Anlässlich ihrer Jahresversammlung zeichnet die Leopoldina ForscherInnen für ihre hervorragenden wissenschaftlichen Leistungen aus. Mehr: leopoldina.org/presse-1/nach… @CoBaStiftung
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I am excited to announce the publication of TADA, a tool to prioritize pathogenic CNVs @GenomeBiology! TADA annotates CNVs with respect to the affected regulatory environment and computes a pathogenicity score indicating their functional impact. genomebiology.biomedcentral.…

TADA—a machine learning tool for functional annotation-based prioritisation of pathogenic CNVs

Genome Biology - Few methods have been developed to investigate copy number variants (CNVs) based on their predicted pathogenicity. We introduce TADA, a method to prioritise pathogenic CNVs through...

link.springer.com
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🦇 Join the lab of @StefanMundlos / @MundlosLab / @der_bri to find out how bats learned to fly! To uncover the complex changes in its genome, apply as a #PhD student & join our #IMPRS-BAC research school! 👉 molgen.mpg.de/3931585/Mundlo…
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Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s41586-0…

ecDNA hubs drive cooperative intermolecular oncogene expression

Nature - Extrachromosomal DNA (ecDNA) congregates in clusters called ecDNA hubs that promote intermolecular interactions between gene-regulatory regions and thereby amplify the expression of...

nature.com
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The Nucleus 2nd edition from @CSHLPress is there👇 Happy to have contributed to it with one chapter together with @StefanMundlos. Thank you to the editors @apombo1 @hetzer_martin @NCITomMisteli for putting it together
Kazuhiro Maeshima@kazu_maeshima21 Nov 2021
The Nucleus 2nd eds. edited by @apombo1 @hetzer_martin @NCITomMisteli is now out @CSHL Press: bit.ly/3kRb035 This exciting book is full of new findings & ideas on the nucleus. We very much appreciate the editors' efforts! Our chapter is available: bit.ly/3kWKIfQ
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Last night, our preprint on the contribution of #RNAPII on #3Dgenome organization transformed into an article in @ScienceAdvances. This is a piece of work very close to my heart (for multiple, mostly non-scientific reasons); thus, a short thread follows: science.org/doi/10.1126/scia…

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis

Following exit from mitosis, RNA Pol II is required for reestablishing 3D genome folding by loading cohesin complexes onto DNA.

science.org
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Herzlichen Glückwunsch! @StefanMundlos wird von der @Leopoldina mit der Mendel-Medaille ausgezeichnet. Der Preis würdigt Pionierleistungen in der #Biologie und #Genetik. @ChariteBerlin @MundlosLab molgen.mpg.de/4422216/

Leopoldina ehrt Humangenetiker Stefan Mundlos

molgen.mpg.de
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Thrilled to share our new paper about genome sequencing as a one-test-for-all strategy for patients with congenital limb malformations. Great team effort by @jonas_elsner @matertius @StefanMundlos Out now: link.springer.com/article/10…
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So happy our review is finally out! Here, we cover various methods molecular biology, microscopy, computational analyses and modelling approaches to study 3D genome organization from a point of view of a regular biologist. nature.com/articles/s41580-0…

Understanding 3D genome organization by multidisciplinary methods

Nature Reviews Molecular Cell Biology - Recent technological breakthroughs in mapping and visualizing chromatin contacts have considerably improved our understanding of 3D genome organization and...

nature.com
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