Cell biologist, Mechanistic dissection of protein folding, quality control, degradation, UPR, and ER-phagy pathways. Non sono direttore di giornale. My opinions
Bellinzona, Switzerland
Joined November 2017
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How does the ER decide whether a misfolded protein is refolded, degraded by ERAD or cleared by ERLAD? Using mutant Neuroserpin, we show that persistent N-glycan glucosylation helps select aggregation-prone proteins for lysosomal clearance.
tandfonline.com/doi/full/10.…
EBV capsids, 100 nm in diameter. To reach the cytoplasm they cross the inner and outer nuclear membranes held 25–50 nm apart by LINC complex. How?
Epstein Barr virus exploits ER stress and TMX4 dependent nuclear envelope remodeling to enable capsid egress biorxiv.org/content/10.64898…
maurizio molinari retweeted
𝟏𝟗𝟒𝟏 – 𝟐𝟎𝟐𝟔 | 𝐂𝐚𝐦𝐩𝐢𝐨𝐧𝐢 𝐒𝐯𝐢𝐳𝐳𝐞𝐫𝐢 🏆
85 anni fa abbiamo scritto una pagina indimenticabile della nostra storia. Con il pareggio casalingo contro i rivali nella corsa al titolo, il BSC Young Boys, abbiamo conquistato il secondo titolo di Campione svizzero.
85 anni di memoria, passione e appartenenza 🤍🖤 ✨
#noibianconeri #fclugano #lug
News on ERLAD: Calnexin:FAM134B:VAPA:ORP1L:RAB7 contact site between ER and endolysosomes to remove misfolded proteins.
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes tandfonline.com/doi/epdf/10.…
Today’s NCB. The cytoplasmic intrinsically disordered regions (IDRs) of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for the ER and mitochondria fragmentation required for lysosomal clearance of the organelle’s portions.
rdcu.be/eF5DR
Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL
ATZ polymers elicit intervention of the CNX:FAM134B-LC3II segregation complex and formation of VAPA-ORP1L-RAB7 membrane contact sites that facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane: ER-to-Lysosome-Associated Degradation.
biorxiv.org/content/10.1101/…
I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".
A1F recognizes 2025 Grant Award Recipients during ATS alpha1.org/a1f-recognizes-20…
maurizio molinari retweeted
New Online! Key challenges and recommendations for defining organelle membrane contact sites bit.ly/4lnIBP1
maurizio molinari retweeted
🚨 New review out in Nature Reviews Molecular Cell Biology!
Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬nature.com/articles/s41580-0…
Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB
Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
@FASEBorg
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology nature.com/articles/s41580-0…
Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB.
mdpi.com/3299382 #mdpiijms via @IJMS_MDPI
Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways.
sciencedirect.com/science/ar…
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We’re proud to share that the Alpha-1 Foundation has been named one of the 2025 Best Nonprofits to Work For by @NonProfitTimes ! This recognition reflects our ongoing commitment to fostering a mission-driven culture that values collaboration, innovation, and impact. Read more: alpha1.org/alpha-1-foundatio…
maurizio molinari retweeted
Alpha-1 doesn’t just affect the lungs, it can impact the liver, too. On #WorldLiverDay, we’re shining a light on Alpha-1 liver disease and the importance of early diagnosis and support. To learn more about Alpha-1 and the liver, visit: alpha1.org/liver-disease/ #Alpha1Awareness
