@MoldovanLab

Genome stability, DNA repair, replication stress, functional genomics, basic cancer biology

 Hershey, PA
sites.psu.edu/moldovan/2016/07/26/hello-world/
Joined December 2020
  • Tweets154
  • Following258
  • Followers1.3K
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Sharing our latest review on single stranded DNA gaps and their impact on cancer chemotherapy outcomes portlandpress.com/biochemj/a…

Understanding single stranded DNA gaps: from formation to fate

Abstract. Single-stranded DNA gaps (ssDNA gaps) have emerged as a potential indicator of therapeutic response in cancer. Accumulation of ssDNA gaps is associated with increased sensitivity of cancer...

portlandpress.com
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Sharing our new paper on the nuclease EXO1. We employed CRISPR genome-wide screening and identified an EXO1 pathway for R-loop suppression doi.org/10.1093/nar/gkag226

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage

Abstract. DNA repair is critical for cellular homeostasis under both normal conditions as well as in response to genotoxic agents such as chemotherapeutics

academic.oup.com
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Sharing our work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. nature.com/articles/s41467-0…

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells

Nature Communications - DNA repair genes are generally considered tumor suppressors, as they maintain genomic stability. Here, the authors show that the exonuclease EXO1 is overexpressed in a...

nature.com
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Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by @theNCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!
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So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
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Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. sciencedirect.com/science/ar…
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Our year in pictures. Happy holidays everyone!
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Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!
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Happy to share our new publications in Nucleic Acids Research on the regulation of PRIMPOL doi.org/10.1093/nar/gkae998 doi.org/10.1093/nar/gkae1068
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Check out our review on the impact of bisphenol A (BPA) on genomic stability academic.oup.com/narcancer/a…

Novel insights into the role of bisphenol A (BPA) in genomic instability

Abstract. Bisphenol A (BPA) is a phenolic chemical that has been used for over 50 years in the manufacturing of polycarbonate and polyvinyl chloride plasti

academic.oup.com
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Congratulations Dr. Khatib! @JudeBKhatib successfully defended her PhD thesis today. Looking forward to her future accomplishments!
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Bittersweet day, saying goodbye to Dr. Ashna Dhoonmoon who leaves the lab today after 5+ tremendous years with us. She was the heart and soul of the lab and we will miss her dearly. @Ashna_Dh All the best in your future career!
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PS. Ashna is not yet done with genome stability: look out for her final paper from the lab coming out (hopefully) soon!
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Happy to share our paper by @JudeBKhatib and @Ashna_Dh on the role of PARP10 in gap filling. rdcu.be/dOOCp
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nature.com/articles/s41467-0…
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Grateful for the opportunity to present our work this week, and happy to see three other former graduate students of the late Stefan Jentsch on this list @PfanderLab @RapeLab @stingele_lab. This one is for you, Stefan!
Zha Lab@zha_lab
18 May 2024
Where is the spring? Are you ready for the summer? Social DNAing is. Check out our 2024 late spring and summer speakers. The website will be updated soon: cancer.columbia.edu/research…. Thank you for helping us RT.
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The final lab selfie with @Lindsey_Pale as member of our group. Wishing her all the best as she transitions into the next phase of her career.
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We attended our Departmental Annual Retreat. @anastasiamhale and @Ashna_Dh gave oral presentations and @JudeBKhatib won the best poster award. Congrats everyone! Stay tuned for their new stories coming out soon!
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Congratulations Dr. Pale! @Lindsey_Pale successfully defended her PhD thesis.
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Happy to share our new manuscript @Lindsey_Pale
bioRxiv Cancer Bio@biorxiv_cancer
20 Apr 2024
CRISPR knockout genome-wide screens identify the HELQ-RAD52 axis in regulating the repair of cisplatin-induced single stranded DNA gaps biorxiv.org/cgi/content/shor… #biorxiv_cancer
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