@MillingLab

Mucosal immunology group with @s_milling at @UofGSii Interested in the intestine's role in human disease (alopecia, IBD, axSpA) & dendritic cells in the gut

 Glasgow, Scotland
dendritic-cell.com/
Joined April 2018
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A fascinating talk from @FredeAnnika today at #BSI22 on the effects of autophagy on Treg cells - always love to hear the work going on in the @kjmaloy lab!
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THANK YOU to all our participants – 65 people with alopecia areata & 38 healthy volunteers – whose generous donations made these discoveries possible! And thank you to @AlopeciaUK, @AstraZeneca & Medical Research Scotland for their funding & support throughout this research!
Photo of Professor Simon Milling & Dr Kym Bain, two of the researcher involved in the study

ALT Photo of Professor Simon Milling & Dr Kym Bain, two of the researcher involved in the study

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Atopy often occurs in people with alopecia – but little is understood about how the diseases are linked. Here, we found that people with both alopecia areata & atopy showed changes to their B cell subsets – could B cells be a key component linking these diseases? 6/🧵
Graphs showing frequencies of B cell subsets from people with alopecia areata classified as atopic or non-atopic, and healthy controls. The frequency of total B cells, transitional B cells, mature B cells, and naïve B cells were increased in people with atopic alopecia areata, while switched B cells were not significantly different compared to non-atopic alopecia areata and healthy controls.

ALT Graphs showing frequencies of B cell subsets from people with alopecia areata classified as atopic or non-atopic, and healthy controls. The frequency of total B cells, transitional B cells, mature B cells, and naïve B cells were increased in people with atopic alopecia areata, while switched B cells were not significantly different compared to non-atopic alopecia areata and healthy controls.

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People with lower levels of hair loss had increased frequencies of CCR6+ and CCR6+ CXCR3+ CD4 T cells, with the increase of Th1/17 cells correlating with increased CD8 memory T cells. Surprisingly, no major changes were seen in circulating CD8 T cells overall 5/🧵
Graphs showing frequencies of CD4 T cell subsets from people with alopecia areata classified as having low levels of hair loss (<50%) or high levels of hair loss (>50%), and healthy controls. The frequency of total CD4 T cells & of CXCR3+ CD4 T cells were not significantly different between the groups. The people with a low amount of hair loss had increased CCR6+ CD4 T cells and CCR6+ CXCR3+ CD4 T cells, along with increased frequencies of CLA+ CD4 T cells and CLA+ CCR6+ CXCR3+ CD4 T cells.

ALT Graphs showing frequencies of CD4 T cell subsets from people with alopecia areata classified as having low levels of hair loss (<50%) or high levels of hair loss (>50%), and healthy controls. The frequency of total CD4 T cells & of CXCR3+ CD4 T cells were not significantly different between the groups. The people with a low amount of hair loss had increased CCR6+ CD4 T cells and CCR6+ CXCR3+ CD4 T cells, along with increased frequencies of CLA+ CD4 T cells and CLA+ CCR6+ CXCR3+ CD4 T cells.

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The Milling lab had a great day at #GUMI2022, filled with fascinating presentations & excellent collaboration opportunities! To top it off, our postdoc @annaandrusaite & our PhD student @A_N_Ferguson won 2nd & 3rd place in the poster prizes 🥳 Looking forward to the next one!
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You are what you eat 👀 another fantastic talk from @BINGO_Group member @KGerasimidis today at #PIBD Congress today! @ESPGHANSociety
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An amazing talk from @bainlab about all things macrophage at #PIBD Congress in #Edinburgh ! His talks always make us re-think what we thought we knew about monocytes & macrophages in health & disease 🤯
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Well done, Dr @annaandrusaite for delivering a great talk at #SIGNET2022 ! She's here all day to answer questions about DC #immunology in gut helminth infections, AND she's always happy to collaborate (that's right, YOU could have your photo featured in her next presentation! 👀)
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Huge congratulations to Dr Andrusaite who successfully defended her PhD thesis today! We're all so proud of you for this incredible achievement @annaandrusaite !
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First Milling and @PeronaLab joint lab meeting went well. Wish we had a mute function in real life to avoid all the sneezes, coughs and hmmmms from interrupting!
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