@MillerLabMIT

Picower Professor of Neuroscience at MIT https://xitter.cf/t.co/UoEeD2FzEY Co-founder, Neuroblox https://xitter.cf/t.co/o6wosMSGen

 Cambridge, MA
ekmillerlab.mit.edu/
Joined May 2011
  • Tweets11.2K
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  • Followers47.3K
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Pavlov’s Dogz rehearsing for Friday's gig at the Pilot in Toronto. Get your tix NOW. Pavlov's Dogz Date: Oct 23 • 19:00 eventbrite.ca/e/pavlovs-dogz…
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Will you be at the Memory Disorders meeting in Toronto. Or in Toronto? Come see Pavlov’s Dogz, the legendary brain punks you've heard so much about. Friday night at The Pilot. Get yr tix NOW! Pavlov's Dogz Date: Oct 23 • 19:00 eventbrite.ca/e/pavlovs-dogz…

Pavlov's Dogz

The Pilot Presents Pavlov's Dogz

eventbrite.ca
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Replying to @632nmPodcast @drmichaellevin @TuftsUniversity
The problem is not emergence. That is a property of nature. The problem is treating it as an explanation, which *some* people do.
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Neural networks in a dish can be trained to bias where their bursts start and to recover from errors. Goal directed closed-loop training of network bursts in cortical cultures produces improved performance and error correction over days doi.org/10.64898/2026.10.15.… #neuroscience

Goal directed closed-loop training of network bursts in cortical cultures produces improved...

Dissociated neural cultures are living systems with no evolutionary history in their current form, which makes them a testbed for asking what goals neural tissue can learn to pursue once it is...

biorxiv.org
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"What" and "where" in frontal cortex, together again. In this case, in a relational code that ties objects to their arrangement. A Relational Code for Objects in Primate Frontal Cortex doi.org/10.64898/2026.10.17.… #neuroscience

A Relational Code for Objects in Primate Frontal Cortex

When we remember a scene, we recall both the locations of individual objects and their spatial arrangement. Yet, how neurons encode this arrangement alongside individual locations is unknown. In this...

biorxiv.org
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Replying to @StuartHameroff
Surprised to hear you say that.
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Earl K. Miller retweeted
Micah G. Allen
@micahgallenOct 20
WaveSpace is a Python tool for analyzing and simulating cortical traveling waves. joss.theoj.org/papers/10.211…
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Change the waves, change your mind. LSD weakens and speeds up two major brain rhythms associated with top-down control, alpha and beta. dailyneuron.com/lsd-alpha-be… #neuroscience

LSD Makes Brain Waves Both Weaker and Faster - Daily Neuron

Brain waves weaken on LSD, but the usual way of measuring them can hide a second change that may set this drug apart from other psychedelics.

dailyneuron.com
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New Results Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia doi.org/10.64898/2026.06.10.… #neuroscience

Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesia

Understanding how receptor-level modulation reorganizes large-scale brain circuits remains a central challenge in neuropharmacology. Here we introduce a multiscale mechanistic model with explicit...

biorxiv.org
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Symposium highlights MIT’s wide range of innovations for aging brain health news.mit.edu/2026/symposium-… #neuroscience @MIT_Picower

Symposium highlights MIT’s wide range of innovations for aging brain health

In six talks, researchers from across MIT described Aging Brain Initiative projects aimed at advancing the understanding of and interventions against neurodegenerative diseases such as Alzheimer’s,...

news.mit.edu
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Theta, alpha/beta, and gamma show nested interactions in frontal cortex with theta as the master clock. Broschard et al (2026) Theta-based organization of information in the frontal cortex. Cell Reports, in press. preprint: biorxiv.org/content/10.64898…

Theta gates and routes information in the frontal cortex

Theta (4–10 Hz) oscillations seem well-suited for coordinating neural activity. Many studies have focused on theta’s role in long-range coordination across brain regions (e.g., connectivity between...

biorxiv.org
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Task-specific theta enhancement and domain-general alpha/beta suppression as oscillatory signatures of cognitive flexibility nature.com/articles/s44271-0… #neuroscience

Task-specific theta enhancement and domain-general alpha/beta suppression as oscillatory signatures...

Communications Psychology - Using time-frequency analysis and latent change structural equation modeling on cued-task switching data, we show that parietal alpha/beta suppression indexes cognitive...

nature.com
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"WaveSpace is a modular Python toolbox for the simulation and analysis of traveling wave dynamics in multichannel recording arrays." joss.theoj.org/papers/10.211… #neuroscience
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Replying to @bimedotcom @thaliafung @_TheTransmitter
The brain reduces its processing load by generating predictions. The cortex is organized around dimensionality reduction. It makes those predictions possible. doi.org/10.1038/s41583-026-0…

Categorization is ‘baked’ into the brain

Nature Reviews Neuroscience - Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective,...

nature.com
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The claustrum contributes to working memory maintenance in mice nature.com/articles/s41467-0… #neuroscience

The claustrum contributes to working memory maintenance in mice

Nature Communications - Neural mechanisms underlying working memory are not fully understood. Here authors show that in mice, the claustrum helps keep memories alive: its neurons sustain...

nature.com
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Memorial for Susumu Tonegawa. I’m glad they included the photo of Susumu and me in hardhats, touring our new building during construction. @MIT_Picower
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Earl K. Miller retweeted
Micah G. Allen
@micahgallenOct 16
Hippocampal neurons encode space and memory in theta phase, even when their firing rate does not change. biorxiv.org/content/10.64898…
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A perceptual echo may come from alpha-frequency resonance in thalamus-cortex loops. It can switch between ringing and non-ringing states Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes cell.com/iscience/fulltext/S… #neuroscience

Thalamocortical network dynamics can explain visual impulse responses and perceptual echoes

Biological sciences; Neuroscience; Sensory neuroscience

cell.com
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Earl K. Miller retweeted
BusinessIntelligence
@bimedotcomOct 16
This paper changed my life: A first glimpse into the ‘middle’ of brain processing thetransmitter.org/this-pape… ✍️ @MillerLabMIT via @_TheTransmitter 👉 MIT neuroscientist Earl K. Miller reflects on a seminal 1985 study by Jeffrey Moran and Robert Desimone which proved that monkeys could focus cognitive attention on different visual stimuli without physically moving their gaze. 👉 This ground-breaking discovery demonstrated that top-down, goal-directed feedback actively modulates how sensory neurons process identical physical inputs, marking a foundational milestone that helped launch the modern field of systems and cognitive neuroscience. 💡 By highlighting a study where the brain's internal focus overrode raw sensory data, Miller illustrates that true intelligence has always been an active act of top-down filtration rather than passive information absorption. @Corix_JC @TheAIObserverX @maponi @JagersbergKnut @ahier @ChuckDBrooks @Shi4Tech @CEO_AISOMA @sallyeaves @ThEiLe0 @rvp @dinisguarda @TarakRindani @FrRonconii @Ym78200 @Nicochan33 @Khulood_Almani @TysonLester @SusanHayes_ @EstelaMandela @JoannMoretti @sulefati7 @FernandaKellner @pchamard @NeiraOsci @darioandriani @ALouiseLavalett @Fabriziobustama @amalmerzouk @arlenenewbigg @mikeflache @RLDI_Lamy @smaksked @Eli_Krumova @PVynckier @chidambara09 @sminaev2015 @Analytics_699 @NathaliaLeHen @MHcommunicate @DanielleLargier

A first glimpse into the ‘middle’ of brain processing

Work by Moran and Desimone showed that monkeys could focus their attention on different stimuli in their visual field without shifting their gaze.

thetransmitter.org
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Study led by Leyla Akay in the lab of Li-Huei Tsai: cell.com/cell-stem-cell/abst…

Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligod...

Akay et al. use a genome-wide CRISPR screen to identify Wnt signaling as a regulator of lipid accumulation in APOE4 oligodendrocytes. Stimulating Wnt signaling by inhibiting GSK3B reduced lipid...

cell.com
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