Dad, husband, 🧠anesthesiologist @neurobesta🇮🇹🇪🇺PhD candidate @umcg 🇳🇱 Juve⚪⚫ and Ferrari🔴 SoMe editor @JcmcSoMe TIVA/NCC/POCUS/BayesT addicted
Joined December 2012
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🎉 Just renewed my commitment as Associate Editor for another three years at the @JcmcSoMe Journal of Clinical Monitoring and Computing !!
Grateful for the continued trust from @ClinMedJournals and @francisco_alobo — your support and leadership are a real motivation 😎💪🏻
Michele Introna retweeted
🚨 Italy’s PM Giorgia Meloni fires back at Trump:
“Donald Trump's statements are completely made up. I am frankly astonished. I don't know why the president of the United States behaves like this towards his allies, after all, it's not the first time it's happened.
I can only say it is disappointing that he does not show the same determination with the enemies of the West and of the United States, whose leaders he instead treats with far greater indulgence," she said, adding: "There is one thing he should remember: neither I nor Italy ever beg."
Michele Introna retweeted
🧵 Albumin in Critical Care: 70 Years, 700 Papers… Zero Benefit
1/
Albumin is the most studied fluid in critical care.
Decades of trials. Endless meta-analyses.
And yet – not a single clinically meaningful benefit.
Here’s why the entire theory collapses once you understand Extended Starling. 👇
🤖 Made with AI
Michele Introna retweeted
🧠 GA targets the brain — yet brain monitoring is still often optional.
pEEG is not a magic number or just awareness detector. It is real-time cortical information to titrate hypnotics, detect excessive EEG suppression, and support safer, anesthesia.
link.springer.com/article/10…
Michele Introna retweeted
Steep Trendelenburg during robotic prostatectomy may increase cerebral oxygenation—but not necessarily as a “good” sign
New #JCMC study: NIRS + optic nerve sheath diameter suggest rising ΔHHb may reflect impaired cerebral venous outflow and congestion
link.springer.com/article/10…
Propofol + remi (TCI?😜)… a simple as that 😇
Best practice in obstetric general anaesthesia: an umbrella review of pharmacological strategies for induction of general anaesthesia
#anaesthesia #MedTwitter #obstetrics
doi.org/10.1111/anae.70214
Michele Introna retweeted
Best practice in obstetric general anaesthesia: an umbrella review of pharmacological strategies for induction of general anaesthesia
#anaesthesia #MedTwitter #obstetrics
doi.org/10.1111/anae.70214
Michele Introna retweeted
Il sorpasso, che un paio d’anni fa si pensava dovesse arrivare nel 2028, ci sarà già quest’anno: nel 2026, l’Italia🇮🇹 toglierà alla Grecia🇬🇷 il primato del paese con il debito pubblico più alto d’Europa. Secondo le previsioni del Fmi, quest’anno il debito dell’Italia salirà al 138,4% del pil mentre quello della Grecia scenderà al 136,9%.
È il prodotto di scelte politiche dagli ultimi tre governi, che tra Pnrr e Superbonus hanno speso 450 miliardi di euro per investimenti che avrebbero dovuto trasformare il paese aumentando produttività e tasso di crescita: il risultato è che l’Italia cresce allo 0,5%, molto meno degli altri ex Pigs (Portogallo, Grecia e Spagna) che crescono al 2%.
L’Italia è l’unico degli ex Pigs che, dieci anni dopo il Covid, avrà un debito pubblico più alto del 2019 e un tasso di crescita del pil uguale al 2019 (<1%).
Le politiche fiscali espansive non hanno funzionato, eppure al centro dei programmi del centrosinistra e del centrodestra ci sono sempre gli “eurobond” (per finanziare un nuovo Pnrr) e la sospensione del Patto di stabilità (per finanziare un nuovo Superbonus).👇
ilfoglio.it/economia/2026/04…
Michele Introna retweeted
the concept that mandating antibiotics within 1 hour of sepsis diagnosis would improve outcomes is deficient in methodological rigor
I explored this logical fallacy 12 years ago (blog below)
we ALREADY went thru the same thing with PNA ~15 yrs ago
emcrit.org/pulmcrit/the-fall…
Another recommendation revisited—and RCTs surprisingly ignored again: Two high-quality trials show no mortality benefit for 1-hour antibiotics in non-shock sepsis, yet the guideline continues to push it.
Recommendation 17: For adults with probable or definite sepsis without shock, we “recommend” administering antimicrobial therapy immediately, ideally within 1 hr (strong recommendation, very low certainty evidence).
Evidence comes from a systematic review and meta-analysis combining 42 observational studies (~191k patients) and 2 RCTs. The guideline argued the RCTs did not show mortality benefit, mostly included non-shock patients, and the median time difference between early and later antibiotics was small (~1–2 h). Based on this, they discounted the RCTs and relied on observational studies—though RCTs provide stronger causal evidence.
These justifications are weak: the RCTs studied exactly the population being recommended, and small timing differences do not invalidate high-quality evidence. Surprisingly, despite new data, the guideline revisited the evidence but effectively ignored it again.
@BradSpellberg @DrToddLee @PulmCrit
Michele Introna retweeted
New in JCMC 🎧 During hepatectomy, the Acoustic Variability Index (AVI) from esophageal phonocardiography predicted fluid responsiveness with AUC 0.873 and cutoff >9.8%, with performance comparable to SVV/PPV in this exploratory study
link.springer.com/article/10…
Michele Introna retweeted
Dexmedetomidine procedural sedation for TAVI showed ~57% incidence of periodic limb movements (PLMs). PLMs occurred across wide sedation depths (OAA/S + BIS) and without EEG cortical arousal, suggesting a subcortical/spinal origin
link.springer.com/article/10…
Great first broad survey about a topic that we explored with our simulation study! More clinical data are needed!
associationofanaesthetists-p…
Target controlled infusions for rapid sequence induction: a national survey of practice
#anaesthesia #MedTwitter #TIVA
doi.org/10.1111/anae.70169
Michele Introna retweeted
Sono interista (non last minute, e mi chiedo cosa sarebbe stato con i social il giorno dopo Iuliano/Ronaldo in quel '98, per fortuna non c'era X) ma questa foto è il contrario dell'esempio offerto da Alcaraz/Sinner per intenderci. Brutta vera.
Michele Introna retweeted
Il designatore #Rocchi fa quello che la totalità dei suoi predecessori non ha mai fatto: ci mette la faccia.
E dice una cosa normale, il dispiacere per un errore grave, insieme a un’altra che sta passando troppo sotto silenzio.
Chi si deve vergognare di quanto accaduto non è l’arbitro (errare è umano) ma #Bastoni che si è comportato in maniera così sleale da rendersi incompatibile con la maglia azzurra.
Michele Introna retweeted
>>> A sinistra, come da manuale, nessuno -comici in primis- che spenda una parola di sostegno. Solo @LucaBizzarri ha palle e spalle sufficienti, gli altri/e tutti silenti. Tutti a iscriversi nel registro dei buoni per non rischiare la paghetta. Schifo. Solidarietà a #Pucci.
Michele Introna retweeted
La sassaiola a #andreapucci è censura preventiva. “Non so cosa dirai in scena, non mi interessa saperlo ma sono troppo virtuoso per permetterti di salire sul palco.” Dalla fangosa nota PD a 4 stronzi anonimi col ditino vivace (la "bufera social") è una gara fra cagasotto. >>>
The investigation by justice will do what courts do best: separate narratives from facts and offer X the opportunity to support its claims of moral superiority by demonstrating that the platform does not facilitate the four offenses listed:
1/ Aiding and abetting the possession and dissemination of images of minors of a sexual nature
2/ Deepfakes produced and disseminated via “Grok”
3/ Production of hateful and antisemitic content via “Grok”
4/ Fraudulent extraction of personal data from an automated data processing system by an organized group
Judicial scrutiny should be a welcome spotlight, not something to run from.
