@MercerLab

Pox Virologist and Systems Biologist, Virus Cell Biology Lab, @IMIBirmingham @UoBbiosciences

 Birmingham, England
birmingham.ac.uk/staff/profiles/biosciences/mercer-jason.aspx
Joined October 2016
  • Tweets2.6K
  • Following1.8K
  • Followers2.1K
806Media
There is not much I can add to what Eva @FrickelLab says here. Don’t take time for granted, life can be short. Leo lived and loved everyday to its fullest. There are no words to describe how much we miss our little boy 💚
Dr Eva Frickel@FrickelLab30 Nov 2022
Our beautiful son Leo aged 4 died on 18th Sep in a freak accident. (1/5)
49
2
174
Jason Mercer retweeted
Melanie Krause@m_krause0206May 18
This points to a direct, regulated interaction between viral proteins and the host lipidation machinery. Thank you to co-authors @ayakimovich, @MercerLab and Ingo Drexler
2
2
101
🔥 Open postdoc position in human inflammation-driven control of infection! Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! Please RT (1/5)
1
26
1
33
5,964
Congratulations to @m_krause0206 for her paper just out in @JCellBiol! See her twittorial below and thanks to all the great collaborations 🙏
Melanie Krause@m_krause02066 May 2024
The main story of my PhD research project is finally out in @JCellBiol today! rupress.org/jcb/article/223/… We were looking at how Vaccinia virus circumvents host immunity by disabling the autophagy machinery through depletion of sequestome-like receptors (SLRs). For a 🧵see below:
1
4
1
31
2,825
Jason Mercer retweeted
Ian White@EM__Ian28 Mar 2024
Paper out with former @LMCB_UCL colleagues @SamolejJ and @MercerLab Cardiac glycosides inhibit early and late vaccinia virus protein expression - go.shr.lc/3J1e2NC
1
7
640
And another one for @SamolejJ! Here he shows how cardiac glycosides (think toad venom) inhibit poxvirus infection. Just out in JGV @MicrobioSoc microbiologyresearch.org/con… Great working with @StrangVirusLab and @EM__Ian once again!!

Cardiac glycosides inhibit early and late vaccinia virus protein expression

microbiologyresearch.org
1
7
29
2,330
Bisbenzimide compounds inhibit replication of prototype and pandemic potential poxviruses! @SamolejJ has extended our understanding of these novel poxvirus inhibitors @StrangVirusLab @MercerLab @ayakimovich mpox work by @cvr_crush journals.asm.org/doi/10.1128…
4
7
1,247
Congratulations to @SamolejJ who shows that bisbenzimides block replication of prototype (vaccinia) and pandemic potential (mpox) poxviruses! Just out in @JournalSpectrum journals.asm.org/doi/10.1128… Excellent collaboration with @StrangVirusLab @CVRinfo @lifearc1 and @ayakimovich

Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses |...

The 2022 mpox (monkeypox) outbreak served as a stark reminder that due to the cessation of smallpox vaccination over 40 years ago, most of the human population remains susceptible to poxvirus...

journals.asm.org
1
5
1
28
3,171
Really happy to see this work out and peer reviewed. Thanks a lot to everyone involved. Here is a happy bleb to entice you into reading our deep dive into vaccinia virus binding!
Jason Mercer@MercerLab8 Feb 2024
Congratulations to @laurapokorny who shows that virus binding proteins aren’t just for binding! Just out in @emboreports Thanks to all who contributed! @JemimaBurden @yorgomodis @D4V1D_4 Becky Bamford,Kendra Leigh,Pooja Sridhar,Timothy Knowles embopress.org/doi/full/10.10…

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

EMBO Reports - Cellular attachment of viruses determines their cell tropism and species specificity. For entry, vaccinia, the prototypic poxvirus, relies on four binding proteins and an...

link.springer.com
1
19
1,263
Congratulations to @laurapokorny who shows that virus binding proteins aren’t just for binding! Just out in @emboreports Thanks to all who contributed! @JemimaBurden @yorgomodis @D4V1D_4 Becky Bamford,Kendra Leigh,Pooja Sridhar,Timothy Knowles embopress.org/doi/full/10.10…

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

EMBO Reports - Cellular attachment of viruses determines their cell tropism and species specificity. For entry, vaccinia, the prototypic poxvirus, relies on four binding proteins and an...

link.springer.com
2
12
1
38
5,420
Today we opened the wonderful play ship for the @HanburySchool children in Leo’s memory. 💚 All made possible by resources, work and enthusiasm of our friends, community and the school. 😍 We are grateful Leo’s ship will bring years of fun to the kids. 🙏
HanburyCofEFirst@HanburySchool21 Dec 2023
Children at Hanbury C of E First School celebrated the launch of a spectacular new play area, built to celebrate the life of one of their beloved classmates. HFS Leo was “launched” today by Leo Mercer’s family. hanbury.eschools.co.uk/web/p…
1
75
5,414
💥 Out now @ScienceMagazine. @DanielHFisch solves the mystery of bystander cell protection during infection. An exciting mechanism, cells are so smart! PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection | Science science.org/doi/full/10.1126…
31
53
10
212
48,438
We miss you Leo at Christmas and every day. 🎄💚
15
2
188
53,767
The @WorcCathedral Christmas Tree Festival features trees decorated by local schools & other organisations. Ours celebrates the life of Leo and aims to reflect things he loved; nature, the colour green and the great outdoors. Admission is free until 8 Jan: tinyurl.com/TreeFest22
1
1
19
As expected, the quality of science presented remained high also on the 2nd day. Many thanks to @MercerLab (@IMIBirmingham, @UoBbiosciences), @YamauchiLab (@ETH_en), Serge Mostowy & Ana Lopez Jimenez (both @MostowyLab, @LSHTM) for being with us this morning. #MLIDS @CASUSscience
2
7
This takes “spying on your neighbours” to a whole other level !
2
3
42
Less than 24 hours to go until #molmicro2022... 4 years worth of organising, unorganising, and reorganising through the pandemic to get to this point. It'll be great to finally see everyone in the morning. Big thanks to our almost 200 delegates for making this happen.
1
4
3
31
Made it to Germany!
2
23
What’s not to love about French cooking 😚
2
8
Calling all DNA virologists: job opening closing soon 👇 kuleuven.be/personeel/jobsit…
4
2
Load more