@MenonLab
 New Haven, CT.
Joined November 2023
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10/10 Read the entire article and learn more ⬇️ medicine.yale.edu/internal-m…

Genetic Variants Shed Light on Kidney Transplant Rejection

New research from Yale School of Medicine's Madhav Menon, MD, MBBS, identifies a potential genetic mechanism underlying the increased risk of kidney transplant

medicine.yale.edu
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Congrats to the Menon Lab on this exciting work! APOL1 risk alleles influence T-cell activation through altered Ca²⁺ signaling downstream of TCR activation, offering new insights into transplant rejection biology
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Goodbye and best wishes to Tanvir as he begins an exciting new chapter! It’s been a pleasure working together, and your positivity and dedication will be missed. Wishing you all the success and happiness in what’s ahead 🚀
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A new study identified a common gene, which is believed to play a role in kidney fibrosis. The mutation, Shroom3, is carried by roughly 40% of people in the U.S. Learn more about the research from @YaleNephrology's Dr. Madhav Menon. medicine.yale.edu/internal-m…

Yale Researchers Target Hidden Trigger of Kidney Scarring

In his latest study, Yale School of Medicine's Madhav Menon, MBBS, MD, finds a genetic clue that may explain why some kidneys fail faster than others.

medicine.yale.edu
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Grateful to YSM News and Recognition for featuring our Shroom3 kidney fibrosis project. Congratulations to the team, and thanks to our collaborators across Yale, the Icahn School of Medicine at Mount Sinai, and the University at Buffalo. medicine.yale.edu/news-artic… @YaleNephrology

Yale Researchers Target Hidden Trigger of Kidney Scarring

In his latest study, Yale School of Medicine's Madhav Menon, MBBS, MD, finds a genetic clue that may explain why some kidneys fail faster than others.

medicine.yale.edu
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Menon Lab retweeted
Madhav@madhavcmenonJan 3
pubmed.ncbi.nlm.nih.gov/4146… Online now @MenonLab

Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction -...

Enhancer variants in Shroom3 associate with renal fibrosis (TIF), but with reduced albuminuria. Detailed mechanisms for these pleiotropic effects are unclear. Here, we focus on identifying the...

pubmed.ncbi.nlm.nih.gov
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Menon Lab retweeted
Madhav@madhavcmenon26 Dec 2025
Thankyou @asnpublications for highlighting this @MenonLab @YaleNephrology @gabriel Barsotti
ASN Publications
@asnpublications26 Dec 2025
Long-term kidney allograft survival remains an important clinical challenge. Check out this #ASNKidney360 review discussing the mechanisms behind it: kidney.pub/KID1091
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At the Yale Life Sciences Pitchfest (Dec 4), semifinals for the Blavatnik Fund for Innovation. Anand Reghuvaran and Gabriel Barsotti from the Menon Lab presented work on the SHROOM3–ROCK interaction, designing precision therapeutics for chronic kidney disease. @YaleNephrology
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Menon Lab at @ASNKidney #KidneyWk — John Pell in the oral presentations and Gabriel in the poster sessions. Proudly representing Yale Nephrology!!
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🚀 Excited to share our new preprint! Design and development of a urinary cell-pellet mRNA PCR-based assay for progressive kidney disease (Nephro-Dx)! 💧🧬Read here 👉medrxiv.org/content/10.1101/… @Ashu230183 @madhavcmenon @YaleNephrology @YaleMed

Design and development of a urinary cell pellet mRNA PCR-based assay for progressive kidney...

Progressive chronic kidney disease (CKD) is a major source of public health spending. Current non-invasive tests estimate CKD but provide a minimal understanding of cell- or compartment-specific...

medrxiv.org
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Menon Lab retweeted
Madhav@madhavcmenon12 Sep 2025
Chocolate cake for all. Diabetogenic birthday … @MenonLab
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Congratulations to E M Tanvir, who will receive a Ruth L. Kirschstein NIH fellowship (T32) to study LIMS1-GCC2 mismatches in Kidney transplantation. #YaleHTI @YaleNephrology @madhavcmenon @Yale @EMTanvir4
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Exciting work from Menon Lab! John Pell presented at the Yale Human and Translational Immunology Retreat on the T cell-intrinsic role of APOL1 risk alleles in allograft rejection, shedding light on novel mechanisms of transplant outcomes. Stay tuned!
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Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects - Kidney International Reports kireports.org/article/S2468-… ! @YaleNephrology @YaleIMed

Focus on a CKD-Associated Locus: SHROOM3 and Other Suspects

The genetic basis of chronic kidney disease (CKD) remains incompletely understood. Genome-wide association studies have repeatedly identified loci on chromosome 4q21.1 to be associated with lower...

kireports.org
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🎶 Tonight, John Pell, a member of the Menon Lab, along with the Yale Medical Symphony Orchestra showcased musical talents at the Fall Concert. 🍂🎻 Thank you to everyone who joined us for an evening of beautiful music! #YaleMusic #MenonLab #FallConcert
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Replying to @Nephronette
@Nephronette presented her RCT of Early, Individualized Recommendations for Hospitalized Patients With AKI on the big stage at @ASNKidney #KidneyWk as it was being released online in @JAMA_current ! Check it out 👇! Congrats to the whole KAT-AKI Team! jamanetwork.com/journals/jam…

Individualized Recommendations for Acute Kidney Injury

This randomized clinical trial tested whether recommendations from a kidney action team tailored to individual patients presenting with acute kidney injury would improve clinical outcomes, kidney...

jamanetwork.com
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Congratulations to Anand Reghuvaran for presenting his research on Shroom3-Rock Interaction and Profibrotic Function at #KidneyWk 2024, contributing to our understanding of CKD mechanisms. Well done! 👏🔬
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Wishing a very Happy Birthday to Dr. Menon! 🎂🎉 Today’s lab meeting had a perfect mix of science and cake! Here’s to more groundbreaking research and even more celebrations! 🧬🍰 #ScienceCelebration #LabLife #HappyBirthdayDrMenon
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A truly enlightening session at the Medical Grand Rounds today with Dr. Menon's talk on "Unravelling the Role of Donor-Recipient Mismatches in Non-HLA Genes in Long-Term Kidney Transplant Failure." His insights were thought-provoking! @YaleIMed @YaleNephrology
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Dr. @madhavcmenon delivered a beautiful MGR this morning on both non-HLA D-R mismatches & APOL1 high risk variant contributions to chronic allograft rejection. Two clear, compelling, & thought-provoking stories which inspired us all this morning. Incredible work @MenonLab!!
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