Of interest to those focused on neurogenetics, lysosomal biology, and neurodegeneration: doi.org/10.1172/JCI195336 Dimitri Krainc & team @NUFeinbergMed identify BORCS5 variants in cases with a broad spectrum of neurological disorders and reveal a novel role for #BORCS5 in lysosomal function. The figure: Neuroimaging findings in control (top) and cases with BORCS5 missense and splice-site variants. #Neurogenetics