@MegeneyLab

We study the fascinating non-lethal biology of caspase/metacaspase proteases ☠️. We are also interested in the molecular cues that manage cardiac remodeling🫀

 Ottawa Hospital Research Inst.
ohri.ca/profile/lmegeney/profile
Joined March 2023
  • Tweets367
  • Following184
  • Followers122
49Media
Lynn Megeney retweeted
Terry Hébert@THebertMcGillSep 11
Eight years of work! So proud of the whole team! nature.com/articles/s44385-0…

Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients...

npj Biomedical Innovations - Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy

nature.com
1
3
7
473
New @ScienceAdvances paper: Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy. #DMD tinyurl.com/36crszy6

Engineering suppressor tRNAs for effective treatment of Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a fatal disorder caused by loss of dystrophin, a protein essential for muscle cell integrity. To date, no therapeutic has restored full-length dystrophin....

science.org
2
8
1,151
Lynn Megeney retweeted
Peter MacKay@PeterMacKayJul 24
In his 90th yr our beloved father Elmer was called home. His was an extraordinary life, collecting legions of friends leaving a legacy of hard work & public service. He loved the forest, poetry, sport, law & good debate, the Yankees & especially his family. Deeply missed & alive in our hearts. Sleep well Pop, you earned your rest.
217
94
24
1,286
77,993
Lynn Megeney retweeted
Ben Weaver@WeaverScienceMay 5
Just published!! Congrat's to my post-doc Wang for getting featured on the cover of Science Signaling. So proud!! So much more to learn about phenotypic plasticity. science.org/eprint/XZZZRR72V…

A Caenorhabditis elegans spatiotemporal proximity atlas reveals the MAPK p38 as a generator of...

Proximity labeling identifies factors that contribute to p38-driven phenotypic plasticity in C. elegans.

science.org
2
6
1
16
2,051
Lynn Megeney retweeted
Ben Weaver@WeaverScienceMay 14
Excited to share the news!! So proud of my postdoc Wang now promoted to Research Scientist!! Protein coordinates responses to environmental stress: Newsroom - UT Southwestern, Dallas, Texas utsouthwestern.edu/newsroom/…

Protein coordinates responses to environmental stress

UT Southwestern Medical Center researchers have discovered a key molecular mechanism that allows animals to adapt to changing environmental conditions without altering their genes – an ability known...

utsouthwestern.edu
2
1
9
1,516
Lynn Megeney retweeted
Science News
@ScienceNewsJan 6
Lung cancer patients who received an mRNA COVID-19 vaccine within a few months of immunotherapy lived nearly twice as long as unvaccinated patients. sciencenews.org/article/canc…

Cancer treatments may get a boost from mRNA COVID vaccines

Cancer patients who got an mRNA COVID vaccine within a few months of their immunotherapy lived longer than those who did not, health records show.

sciencenews.org
118
899
69
2,585
225,637
Book signing with Dr Tony Sanfilippo, and his amazing wife Michelle. Tony is the author of “The doctors we need” ⁦@QueensuDOM⁩ ⁦@KingstonHSC⁩ ⁦@queensutime⁩ -a great read on how Canada can solve its doctor shortage problem-a must read!
6
23
861
Interesting work from @Rudnicki_Lab in @NatureComms : Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis. tinyurl.com/4byakujj
5
20
1,628
Excited to share our paper with Ghayda Mirzaa describing the novel SMARCA1-related NDD. Out today in Nature Communications. rdcu.be/ePaDp
5
1
4
342
We’re proud to celebrate @CincyKidsHeart's Jeff Molkentin, PhD, for receiving @UCincyMedicine's 2025 Daniel Drake Medal—college's highest honor! His groundbreaking work in cardiovascular biology continues to advance science & inspire next-gen researchers: scienceblog.cincinnatichildr…

Molkentin Honored with 2025 Drake Medal - Research Horizons

Jeffery Molkentin, Heart Institute co-director, receives UC's highest honor recognizing his career of pioneering cardiovascular research.

scienceblog.cincinnatichildrens.org
4
6
681
New @NatureComms paper: Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction. tinyurl.com/4knhr7mh

Alterations in peroxisome-mitochondria interplay in skeletal muscle accelerate muscle dysfunction

Nature Communications - The role of peroxisomes in skeletal muscle remains largely unexplored. Here, the authors show that peroxisomal dysfunction and disrupted crosstalk with mitochondria drive...

nature.com
6
18
2,177
embopress.org/doi/full/10.10…
1
2
735
Celebrating an amazing trip up Mount Kilimanjaro with daughter Elizabeth, supported by team Ultimate Kilimanjaro ⁦@UltimateKili⁩ @QueensuDOM⁩ ⁦@queensutime⁩ ⁦@KingstonHSC⁩ -19341 feet of challenging, hypoxic beauty. One of the hardest things I’ve ever done!
3
2
25
1,016
New @NatureComms paper: Large-scale serum protein biomarkers discovery associated with function and clinical milestones in Duchenne muscular dystrophy. #DMD tinyurl.com/34nufjed

Large-scale serum protein biomarkers discovery associated with function and clinical milestones in...

Nature Communications - Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy. In this study, the authors identified proteins in blood that correlate with disease progression,...

nature.com
1
3
22
2,321
Congrats to @LorsonLab and colleagues for their new @hmg_journal paper: Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present early and chronic axonal neuropathy. tinyurl.com/y9x94c8z

Novel neurofilament light (Nefl) E397K mouse models of Charcot–Marie-tooth type 2E (CMT2E) present...

Abstract. Charcot–Marie-Tooth (CMT) is the most common hereditary peripheral neuropathy with an incidence of 1:2500. CMT2 clinical symptoms include distal

academic.oup.com
3
17
878
New @NatureMedicine paper: AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial. #DMD tinyurl.com/bdhwrkka
1
5
22
1,730
Interesting new #JACC paper: Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation. tinyurl.com/2t5rv79t

Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation:

jacc.org
1
12
906
Happy to share that our single-cell analysis of muscle stem cells in two DMD models is now published in Cell Death & Disease. We hope this resource benefits researchers in neuromuscular disease and helps to support the development of stem cell targeted therapies for DMD.
5
5
29
3,529
Huge wall cloud over East Ottawa right now! #onstorm cannot discern rotation
2
7
2
41
4,403
Happy to share our new paper demonstrating optimization of base editing to correct the lethal ACTA2 R179H mutation in human smooth muscle cells in vitro and humanized mice, thereby rescuing multisystemic smooth muscle dysfunction syndrome. ahajournals.org/doi/abs/10.1…
5
32
168
13,069
Load more