T-cell activation, Super-Res Microscopy, Mechanical Forces, Immunotherapy, Traction Force Microscopy
Berlin & Zurich
Joined October 2014
- Tweets69
- Following240
- Followers181
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Enrico Klotzsch retweeted
👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽
We are hiring for a 2y post-doc within the @theglasgowcemi to work on on "Brillouin Microscopy of in-vitro bone marrow models to support early diagnosis of leukaemia". Get in touch if you are interested! linkedin.com/posts/massimova…
Enrico Klotzsch retweeted
Mechanotransduction and how regulates lymphocytes in immunotherapy is what @MechanoImmunLab is presenting right now @Nano4Mech very exciting story!
Enrico Klotzsch retweeted
New #preprint from the lab: using the CD3-zeta gene as an integration locus to redirect T and NK cells with CARs 🎉
Great work by led by @jonas_kath!
Following @j_eyquem TRAC approach, we ventured for an alternative locus suitable for more cell types.
biorxiv.org/content/10.1101/…
Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells biorxiv.org/cgi/content/shor… #bioRxiv
Enrico Klotzsch retweeted
How is Salmonella prepared for efficient host cell invasion? Read more about the dynamic interplay between # Bacterial Flagellum and #SPI-1 during the Salmonella infection cycle in a recent work of our group @Salmo_Lab, @DoaaOsamaSaleh in #PLOSPathogens dx.plos.org/10.1371/journal.…
Enrico Klotzsch retweeted
Reshaping breast cancer's collagen matrix improved T cell infiltration and tumor control in mice.
Could an anti-DDR1 mAb be the next weapon in our immunotherapy arsenal against solid tumors?
@MechanoImmunLab & I discuss the exciting findings by Sun et al @Nature 2021.
Barring the gates to the battleground: DDR1 promotes immune exclusion in solid tumors | Signal Transduction and Targeted Therapy nature.com/articles/s41392-0…
Finally its online ! together with @Vogel_Lab @LabOxenius @MortezaAramesh special thanks to @MichaelLDustin financial support from @HFSP @SNF Nanoconfinement of microvilli alters gene expression and boosts T cell activation pnas.org/content/118/40/e210…
Our collaborative work in a newspaper 💪 @schuetzlab @huppalab #immunology #mechanobiology Entscheidende Zerreißprobe: Wie T-Zellen Krankheitserreger erkennen derstandard.at/story/2000126…
Our collaboration on T Cell forces: #singlemolecule #FRET to quantify forces by individual TCRs during #Tcell activation: pN-forces act laterally. SLB fluidity matters! #Schuetzlab, #Huppalab #Stockingerlab ! nature.com/articles/s41467-0…
Enrico Klotzsch retweeted
Viola Vogel @Vogel_Lab, Bioingenieurin @ETH, erforscht als Einstein Visiting Fellow @BIH_Innovations @ChariteBerlin die mechanischen Kräfte in Zellen. Im Podcast teilt sie ihr Nano-Wissen wie ihre Sicht auf's große Ganze: #Pandemie, #Politik & #Forschung ➡️t1p.de/o61z
Our new paper on: Nanoconfinement of Microvilli Alters Gene Expression and Boosts T cell Activation. together with @Vogel_Lab @LabOxenius funding from @HFSP . biorxiv.org/content/10.1101/…
our latest paper together with researchers in Australia: Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers of Regulated Gene Expression and Translation pubs.acs.org/doi/10.1021/acs…
Our Review on B cells in Immunotherapy @ActaBio
REVIEW by Professor Enrico Klotzsch: External cues to drive B cell function towards #immunotherapy @MechanoImmunLab @ETH_en @HumboldtUni @DRFZ_Berlin @ChariteBerlin sciencedirect.com/science/ar…
Our collaboration with the labs of Profs. Jeschke and Allain finally online. Big congrats especially to Laura and Leonidas !
New work from Gunnar Jeske, Frédéric Allain, and colleagues demonstrates the precise quantification of protein fractions and intramolecular distances in condensed and dispersed phases of FUS. Free to read at rdcu.be/cgpvs. nature.com/articles/s41589-0…
Enrico Klotzsch retweeted
HFSP Young Investigators Enrico Klotzsch @HumboldtUni and Jonas Ries @EMBL and colleagues have developed a traction force #microscopy platform which enables the forces exerted during T-Cell activation to be measured > bit.ly/3pqj9vH
Super excited to see our work finally be published.
pubs.acs.org/doi/10.1021/acs…
#nanoletters #mechanobiology #Immunology #microvilli
Functionalized bead assay to measure 3-dimensional traction forces during T-cell activation -
Studying the force exerting mechanisms of T-cells with our TFM bead assay. #bioRxiv #mechanobiology #TFM #Tcells disq.us/t/3rv6vlg
