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Medicine lost one of its greats this week. My grandpa, Dr. William (Bill) Segar, had an illustrious career that spanned nearly 60 years from @IUMedSchool and @RileyChildrens, @YaleMed, @MayoClinicCV, and @uwsmph and @WiscPediatrics.
Matt Segar retweeted
⚡ A new cardiac technology enters the real world. How do we track its safety?
Pulsed field ablation (PFA) has rapidly expanded for atrial fibrillation treatment.
This study used natural language processing (NLP) to analyze nearly 7,000 FDA post-market reports, exploring:
🔹 Adverse event patterns
🔹 Device malfunction profiles
🔹 Real-world safety surveillance
Officially the funniest copy editor note comment I’ve seen on a manuscript. Not sure how to address it when @VivekReddyMD is an expert on nearly all ablation technologies
“We noticed that a scholar, Vivek Y. Reddy, is cited 9 times, accounting for approximately 42% of the total citations. To ensure a balanced and appropriate citation distribution, we kindly ask you to review these citations and reduce the number of references from this author to no more than 5 citations, retaining only those that are most relevant and necessary for the manuscript.”
Matt Segar retweeted
Welcome to our JULY 29 issue of #JACCCaseReports @JACCJournals featuring Part 2 of the EKG Challenge
jacc.org/journal/case-report….
Full PDF here:
jacc.org/doi/10.1016/S2666-0…
Thank you @aroniskn our Associate Editor for this Editor’s Page:
Clues, Not Patterns: The Electrocardiogram as a Detective Story
jacc.org/doi/10.1016/j.jacca…
@minnowwalsh
@hmkyale
@Justine_Turco
Wide-Complex Tachycardia: VT and VT Mimics
Wide-Complex Tachycardia in a Neonate
jacc.org/doi/10.1016/j.jacca…
Atypical Andersen–Tawil Syndrome in an Asymptomatic Child With Bidirectional Ventricular Tachycardia and Incipient Tachycardiomyopathy
jacc.org/doi/10.1016/j.jacca…
An Extreme Wide-Complex Tachycardia and Tremors
jacc.org/doi/10.1016/j.jacca…
Seamless Transition Between Narrow- and Wide-QRS Tachycardia Revealing Double Tachycardia
jacc.org/doi/10.1016/j.jacca…
AVNRT With Intermittent Aberrancy-Mimicking Ventricular Tachycardia: One Tachycardia, Two QRS Morphologies
jacc.org/doi/10.1016/j.jacca…
Atrial Tachycardia and Bundle Branch Re-Entry Ventricular Tachycardia with Similar QRS Complex Morphology
jacc.org/doi/10.1016/j.jacca…
Irregularly Irregular Wide Complex Tachycardia: Look Beyond the Atrium
jacc.org/doi/10.1016/j.jacca…
Ventricular Tachycardia or Not?: Decoding Post-Cardioversion Wide Complex Tachycardia in a CRT-D Patient
jacc.org/doi/10.1016/j.jacca…
Device Interrogation Unmasking Flecainide-Induced Wide Complex Tachycardia
jacc.org/doi/10.1016/j.jacca…
Wide QRS Tachycardias With Syncope: Two for One?
jacc.org/doi/10.1016/j.jacca…
ST-Segment Deviation Patterns and STEMI Mimics
Takotsubo Cardiomyopathy With Dynamic LVOT Obstruction Mimicking Inferior STEMI
jacc.org/doi/10.1016/j.jacca…
Atrial Repolarization as a Rare Mimicker of ST-Segment Elevation Myocardial Infarction: Revisiting Ta
jacc.org/doi/10.1016/j.jacca…
Reading the ECG in Time: Ta-Wave Pseudo-STEMI and Crochetage Sign in Adult Congenital Heart Disease
jacc.org/doi/10.1016/j.jacca…
Shark-Fin Pattern in aVR Lead as First Manifestation of Acute Left Main Coronary Artery Occlusion
jacc.org/doi/10.1016/j.jacca…
“Left Main” Pattern Electrocardiogram: A Diagnostic Trap for Cardiologists
jacc.org/doi/10.1016/j.jacca…
Isolated Cardiac Rhabdomyoma With Marked ST-Segment Elevation: Benign Tumor, Malignant ECG
jacc.org/doi/10.1016/j.jacca…
Midventricular Hypertrophic Cardiomyopathy With Apical Aneurysm Presenting as Persistent ST-Segment Elevation Mimicking Acute Myocardial Infarction
jacc.org/doi/10.1016/j.jacca…
ST-Segment Elevation Caused by Lung Cancer Mimicking STEMI
jacc.org/doi/10.1016/j.jacca…
ST-Segment Elevation in a Patient With Vocal Cord Cancer: A Great Mimicker
jacc.org/doi/10.1016/j.jacca…
A Dangerous Wave: Recognizing the Shark-Fin ECG Sign in STEMI
jacc.org/doi/10.1016/j.jacca…
Atrioventricular Block and Conduction
A Premature Ventricular Complex as Both Culprit and Cure: Paroxysmal Intrinsic Atrioventricular Block
jacc.org/doi/10.1016/j.jacca…
Progressive Conduction Disease in a Mitochondrial Disorder
jacc.org/doi/10.1016/j.jacca…
From Ophthalmoplegia to Multilevel Atrioventricular Block: Timing Cardiac Device Therapy in Kearns–Sayre Syndrome
jacc.org/doi/10.1016/j.jacca…
Syncope and 2:1 Atrioventricular Block in a Middle-Aged Man
jacc.org/doi/10.1016/j.jacca…
Idiopathic 2:1 AV Block With Ventriculophasic Sinus Arrhythmia in a Young Male
jacc.org/doi/10.1016/j.jacca…
Mobitz Type I Progressing to High-Grade AV Block: Beyond Wenckebach
jacc.org/doi/10.1016/j.jacca…
Intermittent Simultaneous Antegrade Dual Nodal Conduction With Progressive Rate-Dependent Aberrancy
jacc.org/doi/10.1016/j.jacca…
Dual Atrioventricular Nodal Physiology in Sinus Rhythm: An Extraordinary Manifestation of a Common Substrate
jacc.org/doi/10.1016/j.jacca…
The Double Fire Phenomenon With Alternating Right Bundle Aberrancy
jacc.org/doi/10.1016/j.jacca…
Atrial Activation and the PR Interval: Pre-excitation and Impulse-Origin Puzzles
The Many ECG Faces of Wolff-Parkinson-White Syndrome
jacc.org/doi/10.1016/j.jacca…
Left Ventricular Hypertrophy With Pre-Excitation: Thinking Beyond the Usual Hypertrophic Cardiomyopathy Diagnosis
jacc.org/doi/10.1016/j.jacca…
Evaluation of the Elusive Delta Wave in Intermittent Pre-excitation
jacc.org/doi/10.1016/j.jacca…
An Abrupt Doubling of Heart Rate
jacc.org/doi/10.1016/j.jacca…
Junctional Ectopic Tachycardia After Adult Cardiac Surgery
jacc.org/doi/10.1016/j.jacca…
Three Voices of the Atrium: A Unique Case Finding on a Neonate ECG
jacc.org/doi/10.1016/j.jacca…
Repolarization Abnormalities — T-Wave, QT and J-Wave
Wellens’ Sign and Syndrome Detected With the Home Use of a Novel 12-Lead Electrocardiogram
jacc.org/doi/10.1016/j.jacca…
Macroscopic T-Wave Alternans in QTc Prolongation: A Warning Sign Before Torsades de Pointes
jacc.org/doi/10.1016/j.jacca…
Short QT Syndrome Masquerading as Lone Atrial Fibrillation: Hidden in Plain Sight
jacc.org/doi/10.1016/j.jacca…
A Reversible ECG Signature of Hypothermia
jacc.org/doi/10.1016/j.jacca…
QRS Axis, Localization and Artifact
Posteroseptal RVOT PVCs in a Clockwise-Rotated Congenital Heart: A Left-Sided Illusion
jacc.org/doi/10.1016/j.jacca…
Northwest Axis on Electrocardiogram: Decoding an Unusual Cardiac Axis in a Young Patient
jacc.org/doi/10.1016/j.jacca…
Crochetage Sign on Electrocardiography as a Diagnostic Marker of Patent Foramen Ovale
jacc.org/doi/10.1016/j.jacca…
An Electrocardiographic Artifact Mimicking Pacemaker Malfunction
jacc.org/doi/10.1016/j.jacca…
This ECG Does Not Fit: Rethinking Left Ventricular Hypertrophy
jacc.org/doi/10.1016/j.jacca…
Pseudo-Infarction Reversal in Right Precordial Leads: ECG Evolution in Severe Pulmonary Hypertension
jacc.org/doi/10.1016/j.jacca…
@aroniskn
@CraigBasman
@JACabreraCardio
@MiChen__
@aabha_divya
@sarano_maurice
@MarcEngels7
@Miho_Fukui_
@CardioOncCO
@Nishaki1
@MMarinCuartas
@ChrissyMD2000f
@ACHDocTMoe
@PanjrathG
@jsaef1
@Kentso987
@m_taramasso
@SyedZaidMD
Author’s Handles:
@mariaelisasales
@BPushparaji
@MattSegar
@sudarshanballa
@sthangjui
@aronismd
@luisreneps
@DrAvinash_
@dlypourlis
@dr__hunt
@JustinMarkMD
@jennyjlcao
@abhishek_mbbs
@MayoClinicC
@MayoCVFellows
@mazenkawji
@stavrosstavrak1
@drdave0
@AishKamble67
@RobertHelmMD
@YooTaeKyung1
@albcipri6
@LauraDemichiel
Matt Segar retweeted
🚨🫀 AI-ECG for heart failure screening in Kenya
AI-ECG detected LV systolic dysfunction with:
✅ AUC 0.96
✅ Sensitivity 95.6%
Great work @ambarish4786 @NeilKeshvani @MattSegar @JAMACardio
Paper: doi.org/10.1001/jamacardio.2…
#CardioTwitter #AIinMedicine #GlobalHealth #HeartFailure
Matt Segar retweeted
Can standard ECGs flag aortic stenosis years earlier and predict higher mortality post-TAVR? Yes. 🫀
@CardioCareToday highlighted groundbreaking research by Dr. @MattSegar (@Texas_Heart). At AccurKardia, our investigational AK-AVS pipeline is turning the standard ECG into a powerful, predictive biomarker for structural heart disease.
Check the interview: cardiocaretoday.com/post/ai-…
#AorticStenosis #TAVR #HealthTech #Cardiology #MedTech #AI #BetterOutcomes
Matt Segar retweeted
Matt Segar retweeted
On the standards of reporting of P-wave abnormalities in electrocardiographic studies
heartrhythmjournal.com/artic…
Matt Segar retweeted
Electrocardiographic P-wave Parameters and Lifetime Atrial Fibrillation Risk: A Multi-Cohort Study
@MattSegar
heartrhythmjournal.com/artic…
Matt Segar retweeted
New peer-reviewed evidence for AI-ECG in aortic stenosis. Big thanks to Dr. @MattSegar and the Texas Heart Institute team for leading this work.
academic.oup.com/ehjdh/advan…
AK-AVS is investigational and not FDA-cleared.
Matt Segar retweeted
Development and Validation of a Novel Machine Learning-Based Algorithm to Predict Incident Atrial Fibrillation – A Multicohort Analysis
heartrhythmjournal.com/artic…
Matt Segar retweeted
POLY-HF trial: Polypill containing metoprolol, spironolactone, and empagliflozin improved EF, QoL, and adherence, and reduced HF hospitalizations at 6 months in HFrEF patients compared to usual care. #AHA25 View the slides here: clinicaltrialresults.org/wp-…
Interesting case with PMCardio - Queen of Hearts.
On call today and paged to ED for chest pain. ECG looked completely “benign”. Clinical story suggested an ACS event. We decided to take him to the Cath lab anyways, but used the app to see if I missed anything.
QoH noted a STEMI equivalent. Patient ended up having a LCx occlusion. Ended up buying a subscription to the app for that alone.
@PowerfulMedical @MartinHerman_ @RobertHermanMD
I experienced my first AI scribe hallucination today.
What I said: "Heart rate 71 bpm"
What the AI documented: "Electrocardiogram: Normal sinus rhythm"
No ECG was performed. The AI scribe extrapolated from basic vital sign data and generated documentation for a procedure that never occurred.
Remember, AI scribes are powerful tools, but they're not infallible. They can (and will) "hallucinate" by creating plausible-sounding but completely fictional content.
We cannot delegate our professional responsibility to validate documentation. The technology is impressive, but physician oversight remains non-negotiable.
Has anyone else experienced this?
Matt Segar retweeted
AccurKardia launches clinical pilot for AK+ Guard. Three arm study, 150+ patients across care settings. AI hyperkalemia risk from Lead I ECGs, works with FDA cleared wearables. Details: businesswire.com/news/home/2…
(Investigational, not FDA cleared.)
Matt Segar retweeted
On the standards of reporting of P-wave abnormalities in electrocardiographic studies
heartrhythmjournal.com/artic…
Matt Segar retweeted
See you at #ESCCongress 2025 (Madrid, Aug 29–Sep 1)! Join Dr. @MattSegar ’s research using AK-AVS™. Details: lnkd.in/ekKznvMV Meet us: [email protected] (AK-AVS™ investigational) #ESCCongress #WCCardio


























