Mathias Jucker retweeted
Registration is open for the XX International Symposium on Amyloidosis (ISA 2026). Join clinicians, researchers, and healthcare professionals from around the world in Montevideo to explore the latest advances in amyloidosis.
Register today: isaamyloidosis.org/isa-2026-…
Great work::consistent with findings that the release of pTau into the blood might represent a more universal cellular response to any type of amyloid rdcu.be/fus8k
neurology.org/doi/10.1212/WN… we report pTau and other plasma biomarkers in CJD & AD patients. pTau was elevated in CJD patients even without concurrent AD pathology. Cognitive presentations of CJD may be diagnosed as AD if other biomarkers & clinical context is not taken into account
a randomized trial appears necessary
Mathias Jucker retweeted
Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease. My take - Possible limited replication of cwd prions in primates, not entirely ruled out persistence of inoculation. science.org/doi/10.1126/scia…
Mathias Jucker retweeted
This is a superb clinicians review of CAA in NEJM, but in my opinion overlooks the fundamental that CAA is essentially a prion disorder with inherited sporadic and transmitted forms just like CJD. Important for public health to acknowledge this fact and its implications.
Cerebral amyloid angiopathy, caused by beta-amyloid deposition in brain blood vessels, leads to lobar cerebral hemorrhage, microbleeds, and white-matter lesions and contributes to cognitive decline.
Learn more in the Review Article “Cerebral Amyloid Angiopathy” by Steven M. Greenberg, MD, PhD, from Massachusetts General Hospital (@MassGeneralNews) and @harvardmed: nej.md/4n9BPyc
Read a clinical case of a patient with cerebral amyloid angiopathy: nej.md/3RoENTG
ALT Neuroimaging features of cerebral amyloid angiopathy.
Mathias Jucker retweeted
Studying these young Alzheimer's patients led to breakthroughs, but the funding was cut.
npr.org/2026/05/07/nx-s1-575…
One Blood Marker Is Tied to Cognition and Mortality in People Who Live Past 100 medpagetoday.com/neurology/d… #MedPageToday
More evidence that Aβ seeds can trigger the full pathological phenotype of Alzheimer's disease.
High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure jamanetwork.com/journals/jam…
Mathias Jucker retweeted
Straight From the Heart | Neurology - discussion of two new cases of iatrogenic CAA following heart surgery in childhood. Caused by transmission of abeta prions, this should be fairly uncontroversial now. neurology.org/doi/10.1212/WN…
as research briefing: A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses doi.org/10.1038/s41591-026-0…
non-specificity for disease, but specificity regarding mechanism? - pTau elevation in blood as a cellular stress response to the deposition of amyloid
A positive blood tests for #alzheimersdisease might indicate systemic amyloidosis instead, suggesting clinicians should be cautious when interpreting results. @uni_tue ow.ly/xJ5h50YtUGk
Mathias Jucker retweeted
Elevated serum pTau levels are not specific to Alzheimer´s disease and may also serve as diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies @MathiasJucker nature.com/articles/s41591-0…
Alzheimer’s Blood Marker Shows Promise for Heart and Kidney Disease Detection bioengineer.org/alzheimers-b…
Blood marker for Alzheimer’s may also be useful in heart and kidney diseases, via @EurekAlert! @dzne_en eurekalert.org/news-releases…
it is out! Elevated blood p-tau 181 and 217 levels are not specific to Alzheimer disease and may also serve as a diagnostic tool of ATTR and AL amyloidosis! #alzheimer #biomarker. Wonderful collaboration with 3 European amyloid centers.
@NatureMedicine doi.org/10.1038/s41591-026-0…
Blood #neurofilament (NfL) could serve as a cross-species biomarker for #aging interventions and #mortality prediction | PLOS Biology plos.io/46iNxiX. -- To better understand mortality predition across an even wider range of species, we are now looking for more samples!
Neurofilament Light (NfL) may serve as a cross-species blood biomarker for assessing ageing interventions and predicting mortality. It was great fun to measure NfL in all these speceis, even in a crocodile!
Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journal.…
Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journal.…
We discovered these astrocytic inclusion >25 y ago (DOI: 10.1126/science.1542796); Very satisfying to finally see the genetic linkage. Great work. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus: Cell Systems cell.com/cell-systems/fullte…
