📢Our new Nature Disease Primer (@DiseasePrimers) on Major Depressive Disorder examines the epidemiology, mechansims, management, quality of life considerations, and future directions in MDD. Full text link🔗: rdcu.be/dkhzU

A great thread on our new viewpoint I co-authored with @nicholasfabiano & team—exploring how microplastics in ultra-processed foods may affect our mental health. 👇 Thread below.

Interesting new study on ketogenic diet for depression-like symptoms in mice 🧠🐭 📉 KD reduced depressive behaviors in CUMS model 🔥 Lower inflammation (↓ IL-1β, TNF-α, COX-2) 🌱 Boosted hippocampal neurogenesis & BDNF signaling 🔗 Read more: doi.org/10.1039/D5FO00226E

Interesting RCT on gluten-free diet in people with schizophrenia with anti-gliadin antibodies 📌 5-week RCT 📉 GFD > gluten diet for motivation/pleasure (p=0.045) 🧠 No effect on cognition or expressive symptoms 🔗 Read more: buff.ly/5vo0LpI

Thrilled to see @NatGeo highlighting the important connection between diet and mental health! Grateful to be featured alongside esteemed colleagues in the @_ISNPR , as well as other leaders in the field 👉nationalgeographic.com/healt…

Residential greenness & suicide risk in depression 🌿🧠 📊 Data: n=677,498, 8-year follow-up. 🩺 More residential greenness linked to: - Lower suicide attempts (HR 0.789) - Higher impact in males, ages 35-64, & low-income groups 🔗 10.1016/j.envres.2025.121099 – at Melbourne, Victoria

🆕 Pan-European study on ultra-processed food and mortality 📊 Data: n=428,728, 40,016 deaths. 🩺 Higher UPF intake linked to: - All-cause mortality (HR 1.04) - Circulatory (HR 1.09) and digestive diseases (HR 1.12) - Parkinson’s (HR 1.23) 10.1016/j.lanepe.2024.101208 – at Melbourne, Victoria

New prospective study on polyphenols & mortality risk: 📊 12.7 years, 18,173 participants 🍒 Low intake ⬆️ all-cause mortality risk by 32% and cancer mortality risk by 44% 🍫 Top poly sources were cherries, chocolate, apples, olives, coffee 🔗 doi.org/10.1007/s00394-025-0… – at Melbourne, Victoria

Large resource for ultra-processed food research published in Nature Food 📊 Database of 50,000+ items shows degrees of processing. 🥫 Tracks ingredient patterns, food categories, price ranges, and ultra-processing contributors (1,000+ ingredients). doi.org/10.1038/s43016-024-0… – at Melbourne, Victoria

☕ Morning coffee drinkers had lower all-cause (HR: 0.84) & cardiovascular (HR: 0.69) mortality risk vs non-drinkers. ⏰ Timing matters: Morning coffee intake linked to reduced mortality, unlike all-day coffee drinking. 🔗doi.org/10.1093/eurheartj/eh…

New study on intestinal permeability in schizophrenia: 🧠 Elevated LBP (62%) & LPS (25.6%) found, highlighting potential gut involvement. 🥗 Mediterranean diet adherence correlated with reduced I-FABP, suggesting better gut barrier function. 🔗 doi.org/10.1192/j.eurpsy.202… – at Melbourne, Victoria

Recent RCT on probiotics in bipolar & schizophrenia spectrum disorders: 🧠 No significant psychiatric effects, borderline verbal memory improvement. 🦠 Improved gut health & reduced indigestion in males. 🔗 doi.org/10.1093/schbul/sbae1… – at Melbourne, Victoria