Researcher. Biologist. I was once a tiny embryo but now I'm fascinated by them. Postdoc @CCRB27, PhD at reNEW UCPH. @martaperera.bsky.social
Joined November 2017
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Have you ever wondered how the same pathway can elicit different responses in distinct contexts? Check out the second part of my PhD work, now available @Dev_journal
Read the full story here: doi.org/10.1242/dev.202842
Or read the tweetorial below (1/7)
Great work by @mproksik and @nazsalehin ! It works beautifully on the phone as well 😎 Congratulations!
Another Resource developed by @josh_brickman and colleagues presents a reference tool (brickman-preimplantation.str…) based on deep learning models for unbiased annotation of preimplantation embryo datasets.
nature.com/articles/s41592-0…
Very happy to see our story now in the final form. And (perhaps) more importantly, we have contributed with a tree to The Forest of Biologists! 🌲🌳🌿forest.biologists.com/landsc…
Common modes of ERK induction resolve into context-specific signalling via emergent networks and cell-type-specific transcriptional repression
Read this #OpenAccess Research Article from @MartaPrera and @josh_brickman @reNEW_Global:
journals.biologists.com/dev/…
ALT Figure 1 (D) Sox2Cretg/+;Rosa26CRAF/+ E6.5 embryos were fixed and stained after the indicated treatment (Vehicle or 4OHT). HA-tag detection shows expression of the construct restricted to the epiblast driven by Sox2Cre. pERK staining shows induction of the ERK pathway after 4OHT treatment, and no induction when treated with vehicle. Dashed lines indicate the location of the epiblast.
Finally, ERK represses pluripotent transcription in naïve cells and activates it in primed ones (even naïve pluripotency genes in primed cells) suggesting some sort of feedback mechanism accounts for the difference between naïve and primed pluripotent gene expression (6/7)
Finally, although this paper only features @josh_brickman and myself, it could not have been possible without the amazing support of everyone at @Lab_Brickman ! (7/7) #Signalling #Transcription #FGF #ERK #Chromatin
Marta Perera retweeted
Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚
Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging.
bit.ly/3Ya8dEL (1/7)
Marta Perera retweeted
Our latest out today @Nature!
We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬
nature.com/articles/s41586-0…
Marta Perera retweeted
Curious embryo fact 1/25
The embryo is the only machine that needs to function while it is being built.
This is made possible by extraembryonic tissues.
They allow the embryo to breathe without lungs and to eat in the absence of digestive organs.
#embryo #reproduction
Marta Perera retweeted
Paper out today! We used tiny hair fragments from the teeth of the historic #TsavoLions to identify their prey 🦓🦒🦁 @CurrentBiology @FieldMuseum @IGBIllinois @UofIllinois cell.com/current-biology/ful…
Marta Perera retweeted
Just published in @CurrentBiology: Did you know that sea robins use their legs to taste the seafloor? 🐟
The #research reveals how these fish have repurposed their legs as sensory organs to detect prey, combining traits from genes linked to both limb and tongue development.
Marta Perera retweeted
ICYMI: we are hiring! Come and join us @MRC_LMS for a #postdoc
#regulatorylogic #devbio #stemcellmodels in an excellent environment with fantastic support and colleagues :) thenode.biologists.com/jobs/…
A wild Xenopus embryo appeared watching The Substance! It's in the trailer but best enjoyed in a big cinema screen #DevBio #CorruptedbyScience #TheSubstance
Did you know that some plants imitate the shape of their plastic neighbours? This year's Ig Nobel winners are here! As usual, setting the standards for the kind of researcher I aspire to become #IgNobelPrize improbable.com/ig/winners/
I'm very grateful that I was able to contribute to this fantastic story! Congratulations @MLAgerholm_ !! #PowerToPrE
Latest in our Plasticity Project, featuring our fave cells, Primitive Endoderm (PrE), and their in vitro model, nEnd. Amazing PhD journey @MLAgerhom, contributors @AnnikaCharlott2 @albooo87 @MartaPrera @mproksik @TeresaKnudsen @MigManzanares (1/11). twtr.to/FfAst
