@MarkPlitt

learning to science good

Joined January 2013
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I am excited to share an updated preprint from my PhD work with @lisa_giocomo! This project was co-led by @KaganovskyNeuro when he was a PhD student with Tom Südhof. 🧵below! Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion biorxiv.org/content/10.1101/…

Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion

Rapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component of synaptic plasticity. However, it is unknown how this process supports specific neural...

biorxiv.org
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I’m excited to share my first preprint, with @john_widloski and @replayprof! We find that self-avoidance dominates the selection of hippocampal replay. biorxiv.org/content/10.1101/… #tweeprint below!

Self-avoidance dominates the selection of hippocampal replay

Spontaneous neural activity sequences are generated by the brain in the absence of external input[1][1]–[12][2], yet how they are produced remains unknown. During immobility, hippocampal replay...

biorxiv.org
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I'm excited to share a preprint reflecting my PhD work with @lisa_giocomo, where we characterized the impact of aging on the medial entorhinal cortex (MEC), a key hub of spatial coding and memory. 🧵below! biorxiv.org/content/10.1101/… (1/11)

Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex

Across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (MEC) function. However, the integrity of cellular and network-level spatial...

biorxiv.org
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We also found that CA1 Stx3 is necessary for expressing in vivo correlates of behavioral timescale plasticity and for plasticity associated with putative sharp wave ripples. This means Stx3-dependent membrane fusion may be a common molecular mechanism for these processes!
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Stay tuned for an updated preprint from @KaganovskyNeuro that digs into the in vitro characterization of Stx3-dependent plasticity as well as a slew of Stx3-dependent (and independent) behaviors!
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Come check out our #SfN23 posters tomorrow morning! A short 🧵 below!
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Giocomo Lab Posters #SfN2023 !
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The ACR lab will be opening soon @DukeU! We are looking for curious biologists, computer scientists, and neuroscientists to study how the brain "turns on" during development. More info here 👉 bootingupthebrain.org
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It was an immense pleasure to join the ASAP crew & @MichaelLinLab for this project! ASAP4 is an awesome tool for the community! Congrats to all of the authors!
Prof. Michael Lin@MichaelLinLab6 Jul 2023
Today in @naturemethods: our new positively tuned voltage indicator, ASAP4e, for extended electrical recordings in the brain. ASAP4e achieves greater responsivity (>200% per 100mV vs 50% for other fluorescent voltage sensors) and better photostability. nature.com/articles/s41592-0…

A positively tuned voltage indicator for extended electrical recordings in the brain

Nature Methods - The ASAP4 family of genetically encoded voltage indicators allows recording of action potentials and subthreshold activity with either one- or two-photon microscopy over extended...

nature.com
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I am honored to be a part of this impressive group of new Jane Coffin Childs Fellows! Thank you so much @JCChildsFund for this amazing opportunity
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My review with @lisa_giocomo is now out in Current Opinion in Neurobiology! authors.elsevier.com/c/1gH1-… 1/6
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Mark Plitt retweeted
alex gonzalez@alxgnz17 Dec 2022
I'm super excited to share my postdoc work with @lisa_giocomo, "Parahippocampal neurons encode task-relevant information for goal-directed navigation". ¼
bioRxiv Neuroscience@biorxiv_neursci16 Dec 2022
Parahippocampal neurons encode task-relevant information for goal-directed navigation biorxiv.org/cgi/content/shor… #biorxiv_neursci
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The Foster Lab is recruiting postdocs! Please contact David directly if interested, and help spread the word! 🐀 🧠 🥼 👍
David Foster@replayprof3 Mar 2022
My lab is recruiting postdocs. Come to sunny Berkeley and study the latest in hippocampal replay and related neuroscience phenomena. Contact details on our website: ocf.berkeley.edu/~foster/ If you're attending Cosyne, drop me an email and we can meet! Please RT.
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Come and hear about @malcgcamp and my work!
World Wide Neuro 🧠🗺️@worldwideneuro11 Jan 2022
Tomorrow: Online seminar by Alexander Attinger @Alex_Attinger on "Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex", hosted by WWNeuRise | #bot⚡ world-wide.org/seminar/7997
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