@MarieWinz

RNA biologist - co-translational quality control - RNA modification - and beyond.

 Mainz
ak-winz.pharmazie.uni-mainz.de/
Joined February 2019
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Exciting news! We proudly present: the Winz lab’s first research paper now available on bioRXiv @biorxivpreprint! Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay biorxiv.org/content/10.1101/…

Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay

New1 is a homologue of the essential yeast translation elongation factor eEF3. Lack of New1 has previously been shown to induce queueing of ribosomes upstream of the stop codon on mRNAs encoding...

biorxiv.org
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Our study complements and partially confirms previous research by @hauryliuk and @WilsonLab2 and provides starting points for future research about the still-mysterious New1! For more information go read the manuscript! biorxiv.org/content/10.1101/…

Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay

New1 is a homologue of the essential yeast translation elongation factor eEF3. Lack of New1 has previously been shown to induce queueing of ribosomes upstream of the stop codon on mRNAs encoding...

biorxiv.org
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No research without funding... funded by @ItsRMaP1
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A great collaboration with @ButtoTamer and @EPetfalski. Thanks to lab members @lena_tittel and @Kaushik_V_Iyer, as well as the twitterless hero of the story, Max Müller.
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Nice to get good news from a publisher! Our review on quality control pathways working on #ribosome collisions has had over 3,000 views! If you want to learn all about ribosome collisions and how they are handled by cells check out: chemistry-europe.onlinelibra…

Molecular Highway Patrol for Ribosome Collisions

The discovery of ribosome collisions as the recognition platform of translation problems caused by various factors represents a cornerstone in the field of translation surveillance. We summarize our...

chemistry-europe.onlinelibrary.wiley.com
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RNA degradation triggered by decapping is largely independent of initial deadenylation | The EMBO Journal embopress.org/doi/full/10.10…
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How do cells cope with damaged pre-mRNA? It was a great pleasure to discover the answer by @AsifaAkhtar1 and team: with a new kind of stress granules! Check out @AttheHelm3 's and my highlight article: nature.com/articles/s41392-0… , and the original work: sciencedirect.com/science/ar…

Nascent mRNA damage: depot and disposal

Signal Transduction and Targeted Therapy - Nascent mRNA damage: depot and disposal

nature.com
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🚀 Exciting News! 🚀 Thrilled to announce that our reCRAC protocol paper is now out on bioRxiv. Very grateful for the support of my co-authors and colleagues. Read more about reCRAC here: biorxiv.org/content/10.1101/…

reCRAC: A Stringent Method for Precise Mapping of Protein-RNA Interactions in Yeast

Intricate interactions between RNA-binding proteins (RBPs) and RNA play pivotal roles in cellular homeostasis, impacting a spectrum of biological processes vital for survival. UV crosslinking methods...

biorxiv.org
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Hi everyone, in your experience, which kit is best for rRNA depletion in yeast (or other species)? Thanks!
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The recruitment for our PhD Programme at @IBBPAS is now open! Fascinating project exploring the molecular link between RNA polymerase III mutations and human leukodystrophy. findaphd.com/phds/project/mo… #PhD #PhDposition #RNA #tRNA #transcription #mutations #ResearchOpportunity
How mutations in so fundamental machinery such as RNAPIII lead to neurodeveopmental diesease? We are exploring this question using versalite aproaches including #NGS #RNA-protein interactions #ncRNA #CRISPR

ALT How mutations in so fundamental machinery such as RNAPIII lead to neurodeveopmental diesease? We are exploring this question using versalite aproaches including #NGS #RNA-protein interactions #ncRNA #CRISPR

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Happy to share our latest pre-print on RNA polymerase I termination! biorxiv.org/content/10.1101/… #RNAPITermination Fantastic collaboration with @EPetfalski @DTollervey @MarieWinz @EdinburghUni @IBBPAS #Research #RNA

Transcription termination by RNA polymerase I

Transcription elongation is stochastic and driven by a Brownian ratchet mechanism, making it subject to changes in velocity. However, on regions occupied by multiple polymerases, notably the rDNA,...

biorxiv.org
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We are proud to present our new paper in @angew_chem about the new eukaryotic #RNA cap #Ap4A. Decapped by Nudt2, this RNA modification increases the #RNAcap repertoire! Congrats to all the authors!!! onlinelibrary.wiley.com/doi/… @IOCBPrague @science_charles

Diadenosine Tetraphosphate (Ap4A) Serves as a 5′ RNA Cap in Mammalian Cells

Diadenosine tetraphosphate-RNA (Ap4A-RNA) is found in human and rat cell lines. Its amount is not dependent on the intracellular concentration of Ap4A. Ap4A-RNA is decapped by two enzymes, NUDT2 and...

onlinelibrary.wiley.com
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Marie-Luise Winz retweeted
Jaeschke Lab@JaeschkeLab7 Nov 2023
Are you a motivated young scientist with a strong interest in #RNA biochemistry? Our research group at @UniHeidelberg is offering a new #PhD position (fully funded by an @ERC_Research grant) in the field of #epitranscriptomics! More info at: jaschkelab.de/join Please RT!
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Marie-Luise Winz retweeted
König Lab@koenig_lab27 Oct 2023
Join for the "RNA Modification and Processing" conference to enjoy discussion, exciting talks and presenting your own work! More info here: trr319-rmap.de/symposium/ Organised & funded by: @ItsRMaP1, @AttheHelm3, @francescatuorto, @koenig_lab, @dfg_public
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