@MargolisLab

https://xitter.cf/t.co/9nqGlCuvB0 Neuroscience lab interested in imaging neural circuit activity in mice

 Rutgers, New Brunswick
bsky.app/profile/margolislab.bsky.social
Joined May 2013
  • Tweets4.5K
  • Following1.2K
  • Followers4.4K
416Media
David Margolis retweeted
Doris Tsao
@doristsaoOct 17
1/ We discovered something totally unexpected about the neural structure of consciousness that overturns decades of thinking on its biological basis and brings us significantly closer to the recipe for generating conscious awareness. New preprint: biorxiv.org/content/10.64898… (led by @HesseJanis, with @FrankLanfranchi, @_conor_mcgrory, @Yuelin_Shi, and @EngelTatiana)

Rapid alternation of conscious and suppressed stimulus representations in the primate brain

The neural correlates of consciousness remain elusive [1]. Previous studies found that high-level visual cortex is weakly modulated by conscious perception [2,3], yet a pure signal of conscious...

biorxiv.org
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David Margolis retweeted
Takaki Komiyama@takaki_komiyamaOct 14
Our paper is out in Nature, congrats to Qiyu, An et al! By stimulating ~20 motor cortex neurons carefully selected based on their activity, we could induce learned population activity and, sometimes, the movement itself, depending on the brain's state. nature.com/articles/s41586-0…

Targeted stimulation of motor cortex ensembles drives learned movements

Nature - Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating...

nature.com
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David Margolis retweeted
Manuel Beiran@mBeiran27 Oct 2025
So happy to see this work out! We studied when brain connectomes can be used to accurately predict neural activity, and when they can't. Happy to chat more about it, please do reach out if interested. nature.com/articles/s41593-0…
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Chromostereopsis and stereokinetic effect
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Looks impressive 👀🧠 nature.com/articles/s41593-0…
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How does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With @Adrinnenberg from the @KarlDeisseroth lab. (1/8) doi.org/10.1101/2025.10.21.6… @lisa_giocomo
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David Margolis retweeted
Amar Sahay
@AmarSahay_31 Oct 2025
Must read: Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability | Science science.org/doi/10.1126/scie…

Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability

Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in...

science.org
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Thrilled to share our latest work showing spatially segregated Ca2+ signals of NMDAR and mGluR5 have opposing effects to maintain synapse homeostasis, with implications towards rapid antidepressant action (1/3) pnas.org/doi/10.1073/pnas.25…

Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses |...

Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid...

pnas.org
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Our politics MUST become this again, if we are to survive as a country...
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Vaccines are not magic. None are perfect. Some work better than others. Some have serious and occasionally lethal side effects. We don’t understand the downsides of vaccines perfectly. Not everyone needs every vaccine. Some are pushed for profit. The regulatory system around them is flawed and sometimes corrupt. And still … VACCINES ARE ONE OF HUMANITIES GREATEST INVENTIONS.
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ICYMI: Good news! The House rejected the proposed 40% NIH funding cut. The bill released has NIH funded at $48 billion, almost identical to the Senate’s number of $48.7 billion.
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Taxpayers: you reap enormous rewards from your modest investment in scientific research. American science is in grave peril. nytimes.com/2025/08/24/opini…

Opinion | America First? Not When It Comes to Your Health. (Published 2025)

They hoped to make tomorrow’s medicines. Then came Trump.

nytimes.com
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youtu.be/v2utlMxAwtE
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David Margolis retweeted
David Pfau@pfau11 Mar 2025
I'm Jewish. I got my PhD in neuroscience from Columbia in 2014. The biomedical research isn't even on the same campus as the protests. The Joint Task Force to Combat "anti-Semitism" will go down in infamy alongside HUAC. It makes me sick.
NIH
@NIH10 Mar 2025
Today #NIH is terminating more than $250 million in funding—including more than 400 grants—to Columbia University following directives from the Trump Administration’s Joint Task Force to Combat Anti-Semitism. The cancellations are due to Columbia University’s continued inaction in the face of persistent harassment of Jewish students.
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NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report forbes.com/sites/michaeltnie…
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David Margolis retweeted
@LaBonneLaB@labonnelab12 Mar 2025
NIH funding grows the economy while saving lives!!! First Do No Harm!!! NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report via @forbes forbes.com/sites/michaeltnie…
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As far as I can tell, Khalil has still not been charged & his attorney/family still don’t know where he is. Any Jew who thinks this is going to start & stop with a few Palestinian activists is fooling themself. Our community is not an excuse to upend democracy & the rule of law.
Amy Spitalnick@amyspitalnick9 Mar 2025
The Trump admin is exploiting real concerns about antisemitism to undercut democracy: from gutting education funding to deporting students to attacking diversity, equity, & inclusion. As we’ve repeatedly said: this makes Jews - & many others - less safe. jewishpublicaffairs.org/news…
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David Margolis retweeted
Adam Hantman@AdamHantman27 Feb 2025
LISTEN TO EVERY WORD. YES IT IS 12 MIN BUT HE SPEAKS THE TRUTH
Senator Dick Durbin
@SenatorDurbin25 Feb 2025
President Trump and Elon Musk’s funding cuts to groundbreaking medical research do NOT Make America Great. That’s why I’m on the Senate floor introducing a resolution pledging support for NIH & asking for immediate passage. Watch. xitter.cf/i/broadcasts/1lDxLzWgw…
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Senator Dick Durbin

Senator Durbin introduces resolution pledging support for NIH

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