@MarciniakLab

Respiratory doctor @CUH_NHS & @RoyalPapworth. Professor of Respiratory Science @Cambridge_Uni @TheCIMR. Director @CambridgeMBPhD.

 University of Cambridge
med.cam.ac.uk/marciniak/
Joined April 2015
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741Media
Moving notice bsky.app/profile/profmarcini…
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PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress science.org/doi/10.1126/scie…

PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress

Endoplasmic reticulum (ER) stress induces the repression of protein synthesis throughout the cell. Attempts to understand how localized stress leads to widespread repression have been limited by...

science.org
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Marciniak Lab retweeted
Rupert Beale@bealelab8 Aug 2024
We’ve worked out how the molecular machines that create acidic compartments can recruit autophagy (self-eating) machinery when they can’t maintain a pH gradient. We are really pleased with this discovery, out in @MolecularCell cell.com/molecular-cell/full…. 1/16

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

Timimi et al. reveal that the targeting of de-acidified compartments with ATG8s is mediated by a direct interaction between the V-ATPase subunit V1H and ATG16L1. This interaction is important for...

cell.com
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#papworthauthors new publication: CT features associated with contralateral recurrence of spontaneous pneumothorax. buff.ly/4f2Miam #computerisedtomography #CT #pneumothorax @Prof_Marciniak @royalpapworth @royalpapres
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Long-term live-cell super-res microscopy! 👉🏻our new preprint (tinyurl.com/bdjjju45) reports >6h STED imaging of ER dynamics in live cells with seconds time resolution. It combines low-light imaging and NN-assisted denoising🔬
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Wow! "Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis" is a masterpiece! Kudos Drs Tsukui, Wolters & Sheppard for this beautiful work!! Read the paper at nature.com/articles/s41586-0… and super 🧵below from @TatsuyaTsukui
Tatsuya Tsukui@TatsuyaTsukui10 Jul 2024
Fibroblasts are everywhere in our tissue as structural cells, yet we are only beginning to understand them. Today in @Nature, we report that lung-specialized alveolar fibroblasts orchestrate lung homeostasis, inflammation, and fibrosis. 🧵👇(1/n) nature.com/articles/s41586-0…
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It is always satisfying to help mentor a keen student and see the final results published!
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Marciniak Lab retweeted
FrezzaLab@FrezzaLab27 Jun 2024
The extracellular matrix integrates mitochondrial homeostasis: Cell cell.com/cell/fulltext/S0092…

The extracellular matrix integrates mitochondrial homeostasis

Degradation of hyaluronan in the extracellular matrix leads to mitochondrial remodeling, activation of mitochondrial stress responses, and augmented immune signaling.

cell.com
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Fellow @Prof_Marciniak (2011) is leading researchers collaborating with @MassGenBrigham, @AsherOrionGroup & @rhinohealth1 to use #AI to improve diagnosis of #BHDsyndrome, a rare genetic disorder, using a @myrovlytis grant: caths.cam.ac.uk/rare-disease… @BrighamWomens @Cambridge_Uni
Myrovlytis Trust publicity image reading 'Announcing a new collaborative research project funded by the Myrovlytis Trust'

ALT Myrovlytis Trust publicity image reading 'Announcing a new collaborative research project funded by the Myrovlytis Trust'

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Happening now, Niki Veale presents the first talk at the "What's New in Thoracic Cancer?" seminar. Niki Veale, Tim Halim, and Ekpemi Irune present ongoing work in thoracic cancers of unmet need. @TheCIMR @Prof_Marciniak @CRUKCamCentre @CUH_NHS @CRUK_CI
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Every year on June 24th, we raise awareness of BHD and the rare causes of collapsed lung on #WorldPneumothoraxDay. Join us in June to help us spread awareness and empower people with BHD. Keep an eye on our website for updates: thebhdfoundation.org/ @BHD_Foundation
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On Monday 24 June at 6pm GMT, we'll hold an event for #WorldPneumothoraxDay. Our speakers will talk about the latest information relating to pneumothorax & BHD. We'll also host a Q&A session, to give you the opportunity to ask the experts! Register here: lght.ly/9mee6g0
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Marciniak Lab retweeted
TSANZ@tsanz_thoracic24 Jun 2024
June 24 is #WorldPneumothoraxDay Spontaneous pneumothorax can occur in a number of respiratory diseases, eg COPD & IPF; & systemic diseases eg #BHD & LAM. Learn more about these rare diseases at #ARLDSC2024 & at the @BHD_Foundation website shorturl.at/660gE
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Today is #WorldPneumothoraxDay and a great opportunity to make sure patients are informed about their lung condition! Our information hub is full of useful resources including information on pneumothorax, available in several languages. Learn more: ow.ly/y5Ik50Snohk
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Happy #WorldPneumothoraxDay! 🎉 Today, our purpose is to drive awareness amongst medical professionals and the public of #pneumothorax symptoms and BHD. Please join us today and help us spread awareness. Learn all about today in our new blog: thebhdfoundation.org/blog/43…
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Happy #WorldPneumothoraxDay! Today, our purpose is to drive awareness amongst medical professionals and the public of #pneumothorax symptoms and BHD. Please join us today & help us spread awareness. Learn all about today in @BHD_Foundation's new blog: thebhdfoundation.org/blog/43…
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This #WorldPneumothoraxDay, we are raising awareness of the rare causes of pneumothorax. Take a look to learn more about BHD syndrome and pneumothorax. 👇 tinyurl.com/43x8s9az @BHD_Foundation #WPD24 #BHD
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🤔 What is a #pneumothorax? It occurs when the air leaks from the lung. It can be a symptom of an underlying condition such as #BHD. ⬇️ #WorldPneumothoraxDay #WPD24
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BHD is a rare inhertied genetic condition. People with #BHD may not know they have the condition until a health event such as #pneumothorax happens. Learn more about BHD and pneumothorax here: thebhdfoundation.org/blog/43… #WorldPneumothoraxDay #WPD24
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BHD is a rare inhertied genetic condition. People with #BHD may not know they have the condition until a health event such as #pneumothorax happens. Learn more about BHD and pneumothorax here: thebhdfoundation.org/blog/43… #WorldPneumothoraxDay #WPD24
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