@MangesLab

Our lab investigates the role of the human microbiome in the development and maintenance of health! Microbial transplants is our jam 🥗

 UBC and BC-CDC - Vancouver
mangeslab.med.ubc.ca/
Joined December 2019
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  • Following154
  • Followers171
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Hello British Columbia! Are you a renal transplant patient who would be interested in a study evaluating alternative methods for antibiotic resistance organisms treatment? Check out our clinical trail @REACHBC_ reachbc.ca/search#/project/s…
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New review out in Clinical Microbiology Reviews @ASMicrobiology. We explored recent advancements and challenges to the translation of mNGS for viral diagnostics. Check it out below! @MangesLab @bugseq @CDCofBC journals.asm.org/doi/10.1128… – at Vancouver, British Columbia

Agnostic Sequencing for Detection of Viral Pathogens | Clinical Microbiology Reviews

The advent of next-generation sequencing (NGS) technologies has expanded our ability to detect and analyze microbial genomes and has yielded novel molecular approaches for infectious disease diagno...

journals.asm.org
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Check out our latest preprint in collaboration with @VCHhealthcare @bugseq! We assess whether compositional changes in a nasal microbiota as associated with SARS-CoV-2 disease status and COVID-19 severity @MangesLab
medRxiv@medrxivpreprint14 Jun 2022
Alterations in the Nasopharyngeal Microbiome Associated with SARS-CoV-2 Infection Status and Disease Severity medrxiv.org/cgi/content/shor… #medRxiv
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Manges Lab retweeted
BARDA@BARDA3 May 2022
How do we change the paradigm of care for viral infections when testing is limited? #DRIVe is collaborating w/ multiple partners to advance next-generation sequencing diagnostic technologies to detect known & novel respiratory RNA viruses. Read more: medicalcountermeasures.gov/n…
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Manges Lab retweeted
BugSeq@bugseq3 May 2022
How do we change the paradigm of care for viral infections when testing is limited? We’re collaborating with @MangesLab and @VCHRI to advance next-generation sequencing diagnostic technologies to detect known & novel respiratory RNA viruses. Read more: bugseq.com/news/BugSeq-BARDA…
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Full article out now! Check out our latest work published in @PLOSONE through collaboration with @bugseq @UniofOxford @VCHhealthcare @CDCofBC @MangesLab @UBC journals.plos.org/plosone/ar…

Nanopore metagenomic sequencing for detection and characterization of SARS-CoV-2 in clinical samples

Objectives The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies. Metagenomic Next-Generation Sequencing (mNGS) may allow for the detection of pathogens that can be...

journals.plos.org
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Check out our latest preprint! Happy to be a part of this amazing collaborative effort
BugSeq@bugseq24 Aug 2021
Shout out to our collaborators at @FHIOxford @MangesLab @CDCofBC @VCHhealthcare for their amazing work using @nanopore metagenomic sequencing + BugSeq for SARS-CoV-2 identification & characterization!! medrxiv.org/content/10.1101/…

Nanopore Metagenomic Sequencing for Detection and Characterization of SARS-CoV-2 in Clinical Samples

The COVID-19 pandemic has underscored the need for rapid novel diagnostic strategies to detect and characterize pathogens from clinical specimens. The MinION sequencing device allows for rapid,...

medrxiv.org
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Manges Lab retweeted
Zvitambo@ZvitamboZim22 Apr 2021
New preprint from @ruairirobertson @MangesLab & @ZvitamboZim investigating the relationship between gut microbiome composition & oral rotavirus vaccine immunogenicity. #microbiome medrxiv.org/content/10.1101/…

The gut microbiome and rotavirus vaccine immunogenicity in rural Zimbabwean infants

Background Oral rotavirus vaccine (RVV) immunogenicity is considerably lower in low-versus high-income populations; however, the mechanisms underlying this remain unclear. Previous evidence suggests...

medrxiv.org
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Birth weight is the strongest predictor of stunting & other infant health outcomes. Our paper in @EBioMedicine shows that the maternal gut microbiome predicts gestational age, birth weight & neonatal growth @MangesLab @ZvitamboZim @QMUL @QMULBartsTheLon thelancet.com/journals/ebiom…

Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural...

The pregnancy gut microbiome in rural Zimbabwe is characterized by resistant starch-degraders and may be an important metabolic target to improve birth weight.

thelancet.com
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Manges Lab retweeted
Zvitambo@ZvitamboZim15 Dec 2020
New review paper on the potential role for breastfeeding in protection against antimicrobial resistance published today in @BMCMedicine by @mayanads @ruairirobertson @MangesLab @ZvitamboZim @SeqH2O and co bmcmedicine.biomedcentral.co…

Can breastfeeding protect against antimicrobial resistance?

BMC Medicine - The proportion of infections among young children that are antimicrobial-resistant is increasing across the globe. Newborns may be colonized with enteric antimicrobial-resistant...

link.springer.com
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Could a "good community" of bacteria be the answer to the rapidly evolving antibiotic resistance problem? Sign up for the trial if you are eligible and help us explore the mechanisms behind the displacement of the resistant organisms!
Manges Lab@MangesLab11 Feb 2021
Hello British Columbia! Are you a renal transplant patient who would be interested in a study evaluating alternative methods for antibiotic resistance organisms treatment? Check out our clinical trail @REACHBC_ reachbc.ca/search#/project/s…
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Metagenomic sequencing today on our @nanopore MinION...very exciting! #longreads #nanopore @MangesLab
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Our new review in @BMCMedicine - Can breastfeeding protect against antimicrobial resistance? @blizard_inst @qmul @QMULBartsTheLon @MangesLab @mayanads
BMC Medicine@BMCMedicine15 Dec 2020
Can #breastfeeding protect against antimicrobial resistance? Read the new opinion article from @mayanads and colleagues here: bmcmedicine.biomedcentral.co…
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I still remember @nanopore being useful even at 85% accuracy. Mind blowing that you can now read a single molecule at 450 bases pr second at 98% accuracy #nanoporeconf
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Our first operations centre meeting on COVID vaccine roll out was yesterday. We are SO ready to work toward an end game for this pandemic. Big logistical challenge but bring .... it ... ON! @ubcspph @CDCofBC @UBCmedicine
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There were 547 new #COVID19 cases were reported in BC this week. The most likely source of infection continues to be contact with a local case or cluster. While new hospital admissions remain low, there was a small increase: #COVIDBC surveillance report ow.ly/u3Hw50BbPBg
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Advances in microbiome research help us understanding its role in human wellbeing. @colinhillucc highlights, however, that we must ensure that studying the microbiome remains a science and not a belief system via @NutritionSoc & @NS_Publications ow.ly/jG3130r6GNB
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A few photos from our recent (socially distanced) summer lab social! Also a big thank you and farewell to our outgoing Lab Technician @iman_baharmand ! Best of luck in medical school!
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A warm welcome to our new Research Tech (and future MSc student) Nick Gauthier! Joining us from @SFU_Science and the Quarmby Lab
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A giant leap forward in our understanding of the role of the human gut microbiome in drug metabolism, congrats to the @donia_lab cell.com/cell/fulltext/S0092…

Personalized Mapping of Drug Metabolism by the Human Gut Microbiome

Each human has a diverse gut microbiome, which can metabolize drugs differently. In this resource, Javdan et al. present a way to capture and grow much of the unique diversity of human microbiomes in...

cell.com
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