@Mak_Lab_

Of worms and men - regulation of cellular fat storage

 Hong Kong
maklab.ust.hk/
Joined May 2021
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  • Following127
  • Followers122
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We are pleased to share our work on a distant TANGO1 ortholog in C. elegans. A collaboration between Jimmy Mo @oM_ymmiJ, Kwangsek Jung, Yan Li in my lab @hkust and Chao Zhai, Yonghong Yan in Meng-Qiu Dong's lab at NIBS. biorxiv.org/content/10.1101/…

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

Vitellogenin belongs to the Large Lipid Transfer Protein superfamily and is thought to share a common ancestor with human Apolipoprotein B (ApoB) for systemic lipid transport[1][1]–[5][2]. Vitellog...

biorxiv.org
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Our work has now been published @iScience_CP. Check it out for additional analysis and data since the preprint went live. #HKUST #HKUSTResearch A distant TANGO1 family member promotes vitellogenin export from the the ER in C. elegans sciencedirect.com/science/ar…
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@oM_ymmiJ @hkust @iScience_CP
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A great video documenting the day Gary Ruvkun @gary_ruvkun , my postdoc advisor, was awarded the Nobel Prize. youtu.be/sTqJaAVTyLM?si=trze…

Harvard’s Gary Ruvkun awarded Nobel Prize in Physiology or Medicine

Gary Ruvkun, professor of genetics at Harvard Medical School and an...

youtube.com
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We bid farewell to Jimmy Mo @oM_ymmiJ who has been in the lab since 2019, first as an undergrad and then as an MPhil student. Good luck at grad school in St. Louis @WUSTLmed
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Presenting the work of @ZheCAObio on #seipin at the EMBO ER meeting. Showing my age for making a ‘poster’ this way. 😅 Zhe would have done a much better job.
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#APWM2022 においてactive participantだったそうで景品をいただきました。
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Collaboration is a lot of fun. Collaborate with scientists who are also nice, helps with complex issues like authorship etc says @Podbilewicz_lab in the sharing session after a wonderful talk on sexual dimorphism of dendritic arbors in #APWMonline.
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Thank you Marie-Anne and Ping @fungi_worms for sharing your thoughts and suggestions!
Sandhya Koushika@WormlockHolmes19 Jul 2022
Wonderful talks from Marie-Ann Felix & Yen-Ping Hseuh @fungi_worms, followed by a wide ranging conversation w/ both on training (imp to enthuse & attract the next gen), building collaborations (fun) and hybrid conferences (useful) excellently moderated by @Mak_Lab_ #APWM22online
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A great talk by Oliver Hobert on the control of pan-neuronal gene expression by the CUT family of transcription factors. #APWM2022
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Kicking off #APWM2022 with a talk by @wormraiser. Thanks Paul!
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Asia-Pacific Worm Meeting. Online from July 18 to July 20. Marie-Anne Felix, Oliver Hobert, @Podbilewicz_lab, @wormraiser will be the plenary speakers. indico.ust.hk/e/apwm2022 #APWM2022 @wormbase
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Abstract submission deadline approaching: June 30. indico.ust.hk/event/2/abstra… #APWM2022
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The Meeting timetable has been posted. Check out the exciting lineup of speakers. indico.ust.hk/event/2/timeta… #APWM2022 @wormbase @wormraiser @Podbilewicz_lab @Guillou76 @Kavita_Babu_
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Hot off the press...bilingual outreach magazine with articles written by HKUST students. #STEM #STEMeducation @hkustadmissions e-book: bit.ly/3xcfWEP
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Pleased to share the news that our preprint on seipin, primarily by @ZheCAObio has been published @FrontCellDevBio. doi.org/10.3389/fcell.2022.8…
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Starting with an observation made a while ago, a study planned and executed almost entirely by Zhe. @ZheCAObio
Zhe Cao 操哲@ZheCAObio31 Jan 2022
Happy to share my previous work from the Mak lab @Mak_Lab_ , here we characterized a genetic suppressor of worm seipin mutant that acts autonomously in the germline. Hope you enjoy the cyberpunk color scheme used in the figures. biorxiv.org/content/10.1101/…

A flexible network of lipid droplet associated proteins support embryonic integrity of C. elegans

In addition to coordinating the storage and mobilization of neutral fat, lipid droplets (LDs) are conserved organelles that can accommodate additional cargos in order to support animal development....

biorxiv.org
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Work by PhD student Lidan Zeng published @PLOSGenetics. Collaboration with @t_cheung and Qu labs. Implications on how to treat Sjogren-Larsson syndrome. doi.org/10.1371/journal.pgen…
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In one of my roles outside the lab, as the editor of a science outreach magazine for high school students. Articles written by HKUST undergraduates. A new issue is out now. #STEM #HKUST bit.ly/36d9vod instagram.com/sciencefocus.h…
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The ER-resident TMEM-120/TMEM120A promotes lipid droplet expansion by modulating TAG synthesis (not lipolysis). A mutation near the coenzyme A binding site strongly reduces its function. biorxiv.org/content/10.1101/…

The endoplasmic reticulum-resident protein TMEM-120/TMEM120A promotes fat storage in C. elegans and...

The synthesis of triacylglycerol (TAG) is essential for the storage of excess fatty acids, which can subsequently be used for energy or cell growth. A series of enzymes act in the endoplasmic...

biorxiv.org
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