@MacsysCoe

We are MACSYS, an ARC-funded initiative to generate whole cell models for fundamental science, design in synthetic biology, and biotechnology. We compute life.

 Melbourne, Victoria
Joined January 2022
  • Tweets194
  • Following248
  • Followers396
9Media
Please RT: new @MacsysCoe & @TheoryLivingSys webinar by Prof. Bas Teusink theoryoflivingsystems.org/ev… on Wednesday 22nd of November at 3:30pm AEDT (GMT+11 - Syd/Mel/Can). Very much looking forward to our first whole cell modelling seminar.

Prof. Bas Teusink (VU University Amsterdam) | Theory of Living Sys

Optimality and microbial growth strategies

theoryoflivingsystems.org
12
2
15
4,940
One of the important tests for mammalian whole cell models could be to test/explain the multiplicity of phenotypic involvements of functional variants.
Jonathan Pritchard@jkpritch17 Apr 2023
Replying to @SashaGusevPosts @ShaiCarmi
Contrary to what most people expect, the selection distributions are actually quite similar across diverse traits. This is probably because functional variants tend to have effects on many traits. biorxiv.org/content/10.1101/…

Simple scaling laws control the genetic architectures of human complex traits

Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely, including in terms of the numbers, effect sizes, and allele frequencies of significant...

biorxiv.org
3
5
1,937
Take a moment to learn about Julia (the programming language) if you don't already! I think they make some really compelling points in this piece.
Michael P.H. Stumpf@theosysbio6 Apr 2023
Here we show how #julialang enables new biology nature.com/articles/s41592-0… Thanks to @Roesch_E @jgreener64 @adamlmaclean @nassarhuda @ChrisRackauckas Tim Holy, our eagle eyed reviewers & @rita_strack @naturemethods for superb support! I love a good mountaineering analogy 😎
1
9
48
10,998
So happy to see this paper finally published 😍. It was a great collaboration and kudos to @Roesch_E and @theosysbio for leading it. Friends in Biology or any Biology-adjacent field, this paper will likely be very interesting to you: nature.com/articles/s41592-0…
Joe Greener@jgreener646 Apr 2023
Out in final form, our perspective on why the Julia programming language is well-suited to biology: nature.com/articles/s41592-0… Great to do this as part of the @JuliaLanguage community: @adamlmaclean, @nassarhuda, @ChrisRackauckas, Tim Holy and led by @Roesch_E, @theosysbio
1
5
23
3,197
Here we show how #julialang enables new biology nature.com/articles/s41592-0… Thanks to @Roesch_E @jgreener64 @adamlmaclean @nassarhuda @ChrisRackauckas Tim Holy, our eagle eyed reviewers & @rita_strack @naturemethods for superb support! I love a good mountaineering analogy 😎
1
30
6
112
32,719
And this is why @MacsysCoe will base whole cell modelling on #julialang
Dr. Chris Rackauckas@ChrisRackauckas6 Apr 2023
Replying to @ChrisRackauckas
The final result is code that looks like the math but also does not sacrifice features or performance. Yes, that bit right there is runnable code, and that runnable code is one of the fastest chemical reaction simulators out there!
1
7
1,330
2
786
In case anyone missed the original post a while back, here is a *FREE* BioRender equivalent that has image assets compatible with InkScape and other illustrator platforms. bioicons.com/
5
145
744
94,680
BondGraphs.jl: a bond graph modeling framework written in #JuliaLang github.com/jedforrest/BondGr…

GitHub - jedforrest/BondGraphs.jl: Julia implementation of the bond graph framework

Julia implementation of the bond graph framework. Contribute to jedforrest/BondGraphs.jl development by creating an account on GitHub.

github.com
3
9
1,136
Excited to announce that we are significantly expanding the computational biology program at @PeterMacRes. Applications now open for 2 group leader positions! Come and work with me! Please share widely. Closing June 1. careers.petermac.org/job/MEL…

Group Leader

Group Leader

careers.petermac.org
90
3
112
26,041
Bioinformaticians! Two new group leader positions have opened at PeterMac: careers.petermac.org/job/MEL…

Group Leader

Group Leader

careers.petermac.org
12
1
10
2,363
🧵explaining why I won’t be joining institutional #InternationalWomansDay2023 events. If institutions want to be seen as change makers, invest in that. I’ll celebrate you when I see data showing equal recognition and 💰spent on women’s work as on men’s. #Academic #WomenInSTEM 1
This Post is from an account that no longer exists. Learn more
2
3
18
3,138
Climate change is accelerating the emergence and spread of superbugs, which thrive in warm, wet conditions. @CSIRO @ATSE_au urge governments to tackle antimicrobial resistance before we sleepwalk into a superbug's paradise. @OneHealthAu @ConversationEDU theconversation.com/climate-…

Climate change is fuelling the rise of superbugs. What can we do to save ourselves?

Superbugs like it hot and wet, so climate change presents a major challenge for healthcare and agriculture, says a new report from CSIRO and the ATSE.

theconversation.com
2
1
4
620
An excellent Monday morning read. A rallying cry and a reminder that it is a thrilling time to be a theoretical biologist.
Development@Dev_journal24 Feb 2023
New wave theory In his Editorial, Associate Editor @p_r_francois highlights the long history of theory for biology & encourages submissions of theoretical papers describing developing and regenerating systems to Development journals.biologists.com/dev/…
Relative counts of PubMed search results by year for a few scientific terms.

ALT Relative counts of PubMed search results by year for a few scientific terms.

2
10
1,888
For all intents and purposes we’ve moved into our new digs.
2
20
2,006
It was impressive reviewing the papers from our field to show how far understanding has come for the quantitative aspects of bacterial cell surfaces and the processes by which they are made rdcu.be/c6iIS @CentreImpactAMR @MacsysCoe @MonashBDI
5
37
3
134
19,835
The director’s blackboard is on the move to the new MACSYS HQ. See you soon.
1
9
1,444
How do microbial interactions look like in dysbiosis? We performed a large-scale metagenome-wide metabolic modelling study and found that it largely depends on the disease. Preprint here: biorxiv.org/cgi/content/shor… 🧵1/5
1
31
3
135
23,695
Don’t miss the February issue of @CellSystemsCP! It is all about microbial communities! 🦠 Cool perspectives & reviews and many different opinions on the “key challenges for engineering microbiomes” (including my two cents on the topic). 👇🏼 cell.com/cell-systems/fullte…

What is the key challenge in engineering microbiomes?

The microbiome functions that we aim to engineer emerge from a myriad of unknown and dynamic cellular interactions. These functions range from driving biogeochemical cycles in the environment to...

cell.com
9
39
3,031
Looking forward to the @arc_gov_au Centre of Excellence Directors’ Meeting in Canberra today.
3
623
Load more