@MacklinLab

Macklin Lab at @CUAnschutz in the Dept of Cell & Dev Bio @CSD_CUAMC. We study oligodendrocyte signaling, differentiation, and myelination. no relation to Burt.

 Aurora, CO
macklinlab.com
Joined February 2018
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We are so happy to have Adam Almeida's paper available on biorxiv @adam_almeida21 @biorxivpreprint
Adam Almeida@adam_almeida2118 Jul 2022
I am very proud to present the preprint for my graduate work!!! 😊 biorxiv.org/content/10.1101/…

Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through...

Oligodendrocytes in the central nervous system exhibit significant variability in the number of myelin sheaths that are supported by each cell, ranging from just a few to about 50 ([1][1]–[4][2])....

biorxiv.org
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Kristin Dahl a graduate student in the Macklin lab is giving a virtual talk for ASCB tomorrow. Specialized Cell and Evolution ascb.org/ascb-meetings/speci…
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We have submitted our recent paper on mTORC2 signaling in oligodendrocytes to biorxiv.org mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system biorxiv.org/content/10.1101/…

bioRxiv

Welcome to the bioRxiv homepage.

biorxiv.org
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Macklin lab retweeted
Kristin Dahl@kDahl_v26 Dec 2021
I am presenting my thesis work on actin regulation in the production of myelin at ASCB virtual meeting #cellbio2021. Come check out my poster P66: Actin regulation to produce myelin in the central nervous system.
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Congratulations @AppelLabCU and @alexandglia !
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First review published from the lab!!🥳 Congrats @michael_CUAnsch, you did an excellent job! Neuron-Oligodendroglia Interactions: Activity-Dependent Regulation of Cellular Signaling authors.elsevier.com/a/1atpM…
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Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS: Cell cell.com/cell/fulltext/S0092…
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Great thesis update presentation by graduate student Dylan Verden! 🎉🎉 More to come soon!
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First manuscript from the lab accepted!!! 🥳 Awesome work from⁩ ⁦@ClaraBacmeister ⁦@helenajbarr⁩ Crystal McClain with help from ⁦@CGraceWH⁩’s lab. Let the celebrations begin with some mad sabering skills! 🍾
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The Macklin lab skipped work yesterday and went to a wine and painting lesson! Our favorite glial cells made an appearance too. Who knew we had (a few) artists in the group!
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Awesome presentation and impressive work from our rotation student @ChristinaComo ! Goodluck next rotation with @DabertrandFab !
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Beautiful preprint exploring how motor learning affects remyelination in vivo from @EthanHughesLab ! We are very excited to see this come out! biorxiv.org/content/10.1101/…

Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes

Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and degeneration, and activity-dependent myelination may represent an endogenous mechanism to improve remyelination...

biorxiv.org
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One of the main reasons we order from @lightlabs #cookies <3
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Beautiful work from our colleague @doll_caleb exploring a role for FMRP in myelination
Caleb Doll@doll_caleb21 Oct 2019
Myelin is formed at the ends of lengthy oligodendrocyte processes. How do cells manage this growth from such a distance? RNA binding proteins are crucial. Our paper is available in Glia. @KYergert @AppelbhBruce @AppelLabCU #myelin #glia #fmrp onlinelibrary.wiley.com/doi/…
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Had fun showing our miniature fiber coupled microscope in the tools and technology BRAIN initiative social at SfN!
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Can we just talk about how beautiful the cortex/corpus callosum is?? #science #myelin Image/IHC cred: Erin Caples Red = opcs Green = neurons via viral reporter Blue = myelin
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Congratulations to Macklin lab member @adam_almeida21 for passing his comprehensive exam last week! Adam is using zebrafish and mice to study protein and membrane organization in the myelin sheath
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A well preserved myelin sheath is a thing of beauty. @MacklinLab #electronmicroscopy
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Congrats @NicholasMG! Excited to keep you around!
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Thrilled to have @michelle_monje visit @CUAnschutz today and deliver an excellent talk! Quite the crowd, had to find a bigger room! Thanks @EthanHughesLab for hosting
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