@MS_ResearchDoc

Physician-scientist. Neuroimmunologist. Multiple Sclerosis specialist. @WUSTLmed

 St Louis, MO
wuneuroimmunology.com
Joined October 2018
  • Tweets237
  • Following182
  • Followers731
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Gregory Wu retweeted
Claudia Cantoni@ClodidaApr 22
Excited to see our work published in @GreenJournal group! We show that cladribine profoundly reshapes the CSF cell landscape in MS, providing new insights into treatment effects within the CNS. Thanks to all, especially @MS_ResearchDoc and Roman Smirnov! doi.org/10.1212/NXI.00000000…

Dynamics of Spinal Fluid Immune Cell Alterations Following Cladribine Tablet Treatment in Multiple...

Background and ObjectivesOral cladribine tablet (CladT) therapy is efficacious for relapsing multiple sclerosis (MS). However, the mechanisms by which cladribine exerts benefit in MS remain unclear,...

neurology.org
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Gregory Wu retweeted
PeerView
@PeerViewApr 24
New Pathways, New Possibilities in #MultipleSclerosis: Enhance your ability to interpret clinical data to identify ideal candidates for #BTKi therapy with Drs. Jiwon Oh and Gregory F. Wu (@MS_ResearchDoc), 5/27 at 5:00 PM EDT: bit.ly/CharlotteMS26-T #CMSC2026 #neurology
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Gregory Wu retweeted
Joe Sabatino@jsabatino37Feb 5
Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol 🧵1/ nature.com/articles/s41590-0…

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis

Nature Immunology - Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive...

nature.com
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Gregory Wu retweeted
Heinz Wiendl@hwiendl20 Aug 2025
🚨 Paradigm shift in #MultipleSclerosis 🚨 New study in Nature Medicine shows MS is not fixed subtypes but a dynamic continuum of states across 4 dimensions: disability, brain damage, relapses & silent inflammation. 📖 Read: nature.com/articles/s41591-0… #MS #Neurology #AI
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CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling Check out the paper below 👇 jni-journal.com/article/S016…
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Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 @SunnyKimNov2016
Science Immunology@SciImmunology18 May 2025
Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: scim.ag/3EUH8jF
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Pleased to write this editorial with Larry Steinman about a potential novel antibody in MS neurology.org/doi/10.1212/NX… Original manuscript here: neurology.org/doi/10.1212/NX…

Multiple Sclerosis | Neurology Neuroimmunology & Neuroinflammation

neurology.org
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Happy to share this collaborative work looking at long term results of a high efficacy DMT in early #MS #ocrelizumab ⁦@OMRF⁩ ⁦⁦@AaronBosterMD⁩ ⁦@drbarrysinger⁩ ⁦@Brandon_Beaber⁩ ⁦@MSViewsandNews⁩ neurology.org/doi/10.1212/WN…

Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS | Neurology

Background and ObjectivesPatients with multiple sclerosis (MS) may demonstrate better disease control when treatment is initiated on high-efficacy disease-modifying therapies (DMTs) from onset. This...

neurology.org
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Replying to @mzhlab
@mzhlab I am proud to share our manuscript published in @ANA_journals today. 🥳doi.org/10.1002/ana.27157 We used data-driven approaches to analyze paired #CSF and blood #FlowCytometry of 8,790 (discovery) + 3,201 (validation) patients. A #tweetorial 🧵1/16
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Exciting news! Our new paper is published at Annals of Neurology! Check it out to see how large-scale CSF and blood flow cytometry can reveal disease clusters to improve diagnosis and understanding doi.org/10.1002/ana.27157

Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases

Objective Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale remains unknown. Methods...

onlinelibrary.wiley.com
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Using sc-RNA-Seq to delineate T cell changes in AD, demonstrates an up regulation of exhaustion markers in CD8+ T RM cells within 5xFAD mouse brain. Check the link below 👇 jni-journal.com/article/S016…
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I'm excited to announce that Jennifer Lawrence's thesis work is now out! Check it out here: JCI Insight - Microglia drive diurnal variation in susceptibility to inflammatory blood-brain barrier breakdown insight.jci.org/articles/vie…
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Post-mortem MS brain display PD1+ Granzyme B+ tissue-resident memory (Trm) T cells in MS lesions, in contact with EBV infected B cells promoting local CNS inflammation. Check out👇 this 2023 interesting study from @FrancescaAloisi sciencedirect.com/science/ar…
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Replying to @ImmunoFever @MS_ResearchDoc @KateSadlerPhD
Another super important TRP paper that I just came across because of a new paper on how fever impacts CD4 T cell responses by @DarrenHeintzman. Linking the TRPV paper here to add it to this thread: pubmed.ncbi.nlm.nih.gov/3283…

Febrile temperature change modulates CD4 T cell differentiation via a TRPV channel-regulated...

Fever is a conserved and prominent response to infection. Yet, the issue of how CD4 T cell responses are modulated if they occur at fever temperatures remains poorly addressed. We have examined the...

pubmed.ncbi.nlm.nih.gov
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Excessive and repetitive Ampicillin treatment alter the gut-brain axis. Ampicillin induce neuroinflammation through NfL, NOS2 and GFP release. Check out 👇 the work by @TouilBoukoffa team. jni-journal.com/article/S016…
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Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS  #multiplesclerosis #Tcells #EBV 🧵1/ biorxiv.org/content/10.1101/…

Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis

CD8+ T cells are the dominant lymphocyte population in multiple sclerosis (MS) lesions where they are highly clonally expanded. The clonal identity, function, and antigen specificity of CD8+ T cells...

biorxiv.org
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Attending #ASCP2024? Be sure to stop by our booth and say hello to Nikki!
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Incredibly excited to announce that the program will be growing. For 2025, we will be matching 13 applicants (From 11) to a categorical @WashUNeurology PGY-1 position. Ultimately, the program will expand from 44 to 52 residents! @TheNRMP #match2025 #neurotwitter #MedTwitter
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Soluble NCAM-1 and VCAM-1 as potential biomarkers for cognitive decline in inactive primary progressive MS. #CognitionDecline #MultipleSclerosis #PPMS #Biomarkers #Onestepforward #CarloscamaralemarroyLab
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Please RT! My lab is recruiting a Specialist to join us on several exciting new projects related to T cells in MS and novel therapeutic targets. Ideal applicants should have flow cytometry experience. Apply here: aprecruit.ucsf.edu/JPF05166
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