The Miguel Ramalho-Santos Lab does research on Developmental Epigenetics at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto, Canada.
Toronto, Canada
Joined February 2018
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Learn more about the lab's research and news at:
mrsantoslab.org
and
bsky.app/profile/mrsantos.bs…
The #LTRI in Toronto is a diverse + and inclusive community in a multicultural city: we encourage candidates from underrepresented groups to apply! 2 PI positions, by Oct 20.
#womeninscience
#BlackandSTEM
#NativeinSTEM
#NativeScience
#LatinXinSTEM
#MarginSci
#DiversityinSTEM
👇
Job Alert 🚨
We are looking for outstanding candidates to join our institute!
Find out more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
🚨 JOB ALERT 🚨
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @SinaiHealth. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!
Job Alert 🚨
We are looking for outstanding candidates to join our institute!
Find out more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Ending 2024 in style! We found that LINE1s are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together 2 facets of Barbara McClintock’s pioneering work: nucleolar organizer regions and transposable elements. genesdev.org/cgi/doi/10.1...
Also noted: Ribosomal DNA copy number is associated with body mass in humans and other mammals. rdcu.be/dZ3q3
Discussed in @MRSantosLab
lit review: Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration: Cell cell.com/cell/fulltext/S0092…
Miguel Ramalho-Santos Lab retweeted
In a groundbreaking discovery, Sinai Health researchers have found that transposable DNA elements – long considered “junk DNA” because they had no known function – are critical for early human development.
Congrats to Dr. Ramalho-Santos & team at LTRI!
sinaihealth.ca/news/new-rese…
📢@MRSantosLab - LINE1 RNA prevents developmental reversion of human embryonic stem cells to the 8 cell-like state! + new insights on PRC2, nucleolus and chr. 19. Revised and expanded now @Dev_Cell, free access until Dec 4th (earlier version on bioRxiv):
authors.elsevier.com/a/1jxLO…
📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells.
biorxiv.org/content/10.1101/…
👇Key findings:
The results point to a conserved role for LINE1 in repression of developmental reversion in both mouse (@MPercharde et al, Cell 2018) and human. The findings raise fascinating questions regarding transposon evolution and their role in genome compartmentalization.
Excellent team effort driven by postdoc Juan Zhang @LesleyZ618, working with Lamisa Mizan @mizanlam and Kirti Mittal in our lab, and in collaboration with Miguel Esteban, @jeffwranalab and @michaelhoffman. Thanks to all!
Watch this space for an update in the next few months…
Recent review from @MRSantosLab. Everything you wanted to know about hypertranscription but were afraid to ask! This review discusses concepts of hypertranscription & technological advancements to probe global transcriptional shifts in stem cell biology. cell.com/trends/genetics/ful…
Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members + new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions.
mrsantoslab.org
MRS reported latest from our lab on LINE1 in hESCs #ISSCR2024, Hamburg. Great to reconnect with many colleagues, + @bulutkarslioglu @EveCollignon. Excellent science, massive industry show. For respite:
Art Museum,
Caspar David Friedrich, “Wonderer above the sea of fog”, 1817.
