IMMUNOLOGY OF ALLERGIES, IgE BIOLOGY AND B CEL MEMORY. Opinions are Maria's own.
New York, USA
Joined January 2023
- Tweets24
- Following45
- Followers122
- Likes5
Extreme budget cuts for science in Argentina can put in peril generations of scientists. nature.com/articles/d41586-0…
Dear Dusan and Dusanites colleagues: we will miss you big time!!! Best wishes as you move to the other side of town. @BogunovicLab
MariaLafaille Lab retweeted
It’s been 10y since we opened our lab at @IcahnMountSinai. What an exciting ride and supportive environment it has been. We are now moving to @Columbia @ColumbiaPeds. Thrilled at the future and discoveries in genetics and immunology to come. – at New York, NY
ALT Department of Microbiology - 2014
New work from the Victora lab (@victora_lab) explains why in secondary immunizations, new germinal centers form from naïve cells that bind poorly to the antigen. It’s all about pre-existing antibodies! nature.com/articles/s41577-0…
biorxiv.org/content/10.1101/…
Results of the first stage of the NIAID funded CoFAR OUtMATCH trial, involving 10 sites including Mount Sinai (Scott Sicherer, PI) were just reported nejm.org/doi/pdf/10.1056/NEJ…
Important news for pediatric food allergy!! The FDA approved anti-IgE (Omalizumab) treatment to reduce reactions to accidental exposures to allergenic foods. More in nih.gov/news-events/news-rel….
MariaLafaille Lab retweeted
Original Article: Omalizumab for the Treatment of Multiple Food Allergies nej.md/4bLW7aS
Editorial: Options for Multiple Food Allergies — Food Avoidance or Pharmacologic Treatment? nej.md/3IaTeD7
ALT Successful Consumption of Prespecified Threshold Dose at Week 16
ALT Successful Consumption of Prespecified Secondary End-Point Doses at Week 16
Super cool cover for the @ScienceTM Feb 7 24 issue by Claud Spadafora and Joshua Koenig.
MariaLafaille Lab retweeted
This week's new issue of #ScienceTranslationalMedicine has arrived! Researchers uncover stealthy immune saboteurs that drive allergic memory in humans, a new analysis in mice reveals how the brain recovers after stroke, and more. scim.ag/5N7
Check out our paper in @ScienceTM with insight into how B cell memory for allergen-specific IgE antibodies is stored in CD23+IgG1+ memory B cells in kids with peanut allergies. Similar findings in pollen allergy reported in the same issue by @jfekoenig 1/n science.org/doi/10.1126/scit…
When we isolated the cells that directly bind the main peanut allergen Ara h 2, we found that they belong to the Type 2 IgG memory cells, they contain clones that are similar between different individuals, and they produce antibodies that bind Ara h 2 with high affinity. 4/n
Therefore, the findings described in our new @ScienceTM manuscript link these Type 2 IgG memory B cells to the production of peanut allergy-causing IgE antibodies, an important discovery for understanding and treating #FoodAllergy. 5/n
Our new manuscript on by Miyo Ota, Ken Hoehn and collaborators reveals the importance of type2-marked IgG memory cells in food allergy persistence. @SinaiImmunol @hoehnousk @skeinstein
biorxiv.org/content/10.1101/…
B cells in Aranda et al.:In addition to revealing the type2-marked IgG memory B cells, our manuscript has nice scRNAseq analysis of human blood B cells (naïve, memory and plasma from blood of adult atopic and non-atopic subjects. Check it out! @tonestrife @edgarEGK @SinaiImmunol
Aranda et al. shows that 1) type2-marked CD23+IL4R+ IgG memory cells are increased in atopic subjects; 2)
their frequency correlates with the level of IgE antibodies; 3) CD23+IL4R+ IgG memory B cells are best among IgG memory cells to switch to IgE
onlinelibrary.wiley.com/doi/…