|| nerve-tumor at the Simon Lab of @TriIMDPhD || formerly: the Ginty Lab @harvardmed
Joined June 2022
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Incredibly excited to share our (@leonard_qi) preprint from the Ginty Lab studying the Krause corpuscle, a population of sensory endings in the genitalia that detect light touch and vibration to enable proper sexual behavior.
They’re pretty cool looking too :)
Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior biorxiv.org/cgi/content/shor… #biorxiv_neursci
Michael Iskols retweeted
Thrilled to share our new study showing how CSF crosses through arachnoid fenestrations to olfactory meningeal lymphatics: Cell cell.com/cell/fulltext/S0092… A major step toward understanding CSF exit from subarachnoid space.
Excited to share our work showing melanoma-innervating sympathetic axons inhibit tumor growth through suppression of pro-tumor macrophages, opposing growth-promoting nociceptive sensory neurons. Can’t wait to build on this work for my thesis!!
nam12.safelinks.protection.o…
Online now: A local sympathetic-immune axis inhibits melanoma growth in mice by dictating adrenergic control dlvr.it/TSHV7G
Michael Iskols retweeted
The choroid plexus vasculature comes alive: a dense, mechanosensitive network revealed by #liveimaging and #transcriptomics. Check out our preprint on @biorxivpreprint: biorxiv.org/content/10.64898…
Michael Iskols retweeted
Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain.
@hhmi_science
#Neuroscience #BrainPrize2026
Michael Iskols retweeted
aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks
Anna Maria Reuss et al.
doi.org/10.1101/2025.05.21.6…
Michael Iskols retweeted
After many years of work I’m so happy to share our work on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
science.org/doi/10.1126/scii…
Michael Iskols retweeted
🚨Women with ER(–) breast cancer who took aprepitant (anti-nausea drug, NK1R blocker) had a 31% lower risk of metastasis or death (p<0.001) in large Norwegian study by Botteri & Chang. More doses = better survival 📉.Clinically validates our work by @VeenaPadmanaban: neuronal substance P drives BrCA metastasis via tumor NK1R & is blocked by aprepitant. academic.oup.com/jnci/advanc…. @RockefellerUniv @theNCI
ALT https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djaf178/8196554 https://pubmed.ncbi.nlm.nih.gov/39112700/
Michael Iskols retweeted
🎉Exciting news! Our latest work on Glioma-Innervating Neurons has just been published in PNAS!🔗 Read the full article here: pnas.org/doi/10.1073/pnas.24…
A huge thank you to my co-mentors @blsabatini, @HaigisLab and co-authors. @MGHNeuroOnc @MGHCancerCenter @MGHNeurology
Michael Iskols retweeted
This brown bear is performing a “wet dog shake”—a stereotypical behavior observed in most mammals when they get wet or encounter an irritant on their back.
Researchers in Science have now identified a type of light touch–sensitive mechanoreceptor associated with underfur that mediates this behavior in mice. Learn more in this week's issue: bit.ly/3CkDON6
Michael Iskols retweeted
Exciting discovery: CSF flow isn't confined to the brain and spinal cord—it also extends to peripheral nerves! @ScienceMagazine science.org/doi/10.1126/scia…
Groundbreaking research from @UFHealth @UF
#neurotwitter #neuroscience #AcademicChatter
Michael Iskols retweeted
Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye!
The dye is tartrazine, used in Doritos!
science.org/doi/10.1126/scie…
!!!
🚨❗️🚨 New Paper Alert
My postdoctoral work now out in @Nature. We find that sensory neurons drive breast cancer metastasis via an activity-dependent paracrine signalling mechanism mediated by substance-P, extracellular ssRNA & TLR7 receptor. (1/11)
urldefense.com/v3/__https://…$
🧵👇🏾
Michael Iskols retweeted
I'm thrilled to announce that our latest research on chronic vulvar pain has been published in Brain!
doi.org/10.1093/brain/awae22…
@Brain1878
Michael Iskols retweeted
Welcome @MIskols to the lab for your rotation! Here posing with @CharlesXu3 in the neuro team uniform 👏🏼
Alternate career path?
Also check out the Nature podcast that talked about our work with @MIskols open.spotify.com/episode/2c6…
I’ve been incredibly fortunate to work with @leonard_qi on this project over the recent years; we explore a dense population of vibration-sensitive neurons in the genitalia and their contribution to sexual behavior (now including the clitorovaginal reflex) nature.com/articles/s41586-0…
Michael Iskols retweeted
HOWZAT!!!
Nav1.7 as a biomarker of peripheral nerves in mice and primates!!! A fluorescently-tagged 🇵🇪 tarantula NaV1.7-targeted peptide, Tsp1a! 🤯
NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures biorxiv.org/content/10.1101/…
Michael Iskols retweeted
A GWAS of having never experienced a headache in life revealed a signal near ADARB2, which encodes an RNA editing enzyme expressed mainly in the brain. Interestingly, this variant is not associated with migraine or any other forms of headache. Fascinating!
Olofsson et al. Comm Bio
nature.com/articles/s42003-0…
Michael Iskols retweeted
Sensory neuronal control of skin barrier immunity
dlvr.it/T74kZb
Michael Iskols retweeted
Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer biorxiv.org/cgi/content/shor… #bioRxiv