Post doctoral researcher with the Jungmann lab studying T cell synapses using DNA-PAINT microscopy. MPIB She/Her.
Joined February 2020
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Incredibly proud to share that my PhD work is out in Science Signaling and made it to the journal cover!!🥳 Congratulations to all authors and a massive thank you to my supervisors @ssimoncelli and Prof. Andrew Cope.
A new imaging analysis uncovers an important molecular brake on T cell remodeling and activation, in vitro experiments reveal an unexpected role for the cell cycle regulator CDK1, and more this week in #ScienceSignaling. scim.ag/4fyRrts
Megan Joseph, PhD retweeted
Olivia P.L. Dalby, Sabrina Simoncelli @ssimoncelli et al. use super-resolution imaging and reveal that CAR-T cells assemble immunological synapses with distinct actin architectures, including reduced central clearance and enhanced protrusions. hubs.la/Q04r-3kn0
Megan Joseph, PhD retweeted
Thrilled to see our work published today in @JCellBiol! 🎉
Congratulations to our fantastic first author @oliviapldalby. A huge thank you to the entire team: Efstratios Kirtsios, Hale-Seda Radoykova, @ceciliazaza, @MDJoseph97, Persis J. Amrolia, and @AGiustacchini.
Olivia P.L. Dalby, Sabrina Simoncelli @ssimoncelli et al. use super-resolution imaging and reveal that CAR-T cells assemble immunological synapses with distinct actin architectures, including reduced central clearance and enhanced protrusions. hubs.la/Q04r-3kn0
Megan Joseph, PhD retweeted
How do T cells restrain their activation?
A team applies DNA-PAINT to visualize the immunological synapse and shows PTPN22 restricts actin remodeling and antigen sensitivity by interacting with PSTPIP1 at the plasma membrane. @MDJoseph97 @ssimoncelli scim.ag/4axoMl1
Megan Joseph, PhD retweeted
A study identifies how the protein PTPN22 controls how #Tcells remodel their cytoskeletons to form synapses with their targets—and suggests that defects in this constraint mechanism may contribute to #autoimmunity. @MDJoseph97 @ssimoncelli @UCLChemistry scim.ag/4axoMl1
Megan Joseph, PhD retweeted
T-Cell Synapse Formation Is Restrained by PTPN22–PSTPIP1 Signaling
T‑cell synapse remodeling depends on a PTPN22–PSTPIP1 axis that restrains actin dynamics and may offer insights into #autoimmunity
@MDJoseph97 @ssimoncelli @ucl
#cancerimmunotherapy #Tcell
hubs.li/Q04kVck00
Megan Joseph, PhD retweeted
How do T cells restrain their activation?
A team applies DNA-PAINT to visualize the immunological synapse and shows PTPN22 restricts actin remodeling and antigen sensitivity by interacting with PSTPIP1 at the plasma membrane. @MDJoseph97 @ssimoncelli scim.ag/4axoMl1
Megan Joseph, PhD retweeted
New paper out in @SciSignal — and we made the cover! 🎉 We uncovered a new role for autoimmunity gene PTPN22 in shaping the T cell immunological synapse.
science.org/doi/10.1126/scis…
A thread 🧵 1/6
It was a wonderful moment celebrating my PhD graduation! Thank you to everyone who helped me along the way. Especially my primary supervisor @ssimoncelli
New paper from the Simoncelli lab!
It was truly an honour to work with this amazing bunch of researchers. Congratulations to all the authors 🥳
🚨 New paper alert! 🚨
Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔
🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution
📄 nature.com/articles/s41467-0… @NatureComms 🧵👇
What a great way to announce my new post doctoral research position with the @JungmannLab by showing off my amazing graduation hat made by my fellow lab members! Thank you all for my wonderful gifts.
Thrilled to announce that yesterday I passed my PhD viva examination 🥳 Thank you to my supervisors for all their support @ssimoncelli and Prof. Andrew Cope and to @uclbiosciences, @LondonNanotech @KingsCollegeLon, and @LIDo_DTP. Here are some celebratory Simoncelli lab photos
Megan Joseph, PhD retweeted
Thrilled to share our latest work in @NanoLetters! Can we measure association and dissociation constants within cell environments? Check out how we use single-molecule localization microscopy to determine protein-protein interactions in T cells. 🥼🔬 💪 doi.org/10.1021/acs.nanolett…
Megan Joseph, PhD retweeted
Megan Joseph from the Simoncelli group gives the third talk of the annual @UCLChemistry Ramsay Medal Symposium about her work on studying immune cells with super resolution microscopy
Thank you so much Sabrina for helping me start my scientific journey and all your support over the last four years! I'm honoured to have been your first PhD student and I've learnt so much from you.
Congrats to my first PhD student, Megan @MDJoseph97, on submitting her thesis today! 🎉 It’s been an absolute honor to supervise you, and I’ve learned so much from your incredible work. Best of luck in your new postdoc – I know you’ll do wonders! 🌟 #ProudSupervisor #NextChapter
#SMLMS2024 was an amazing experience! Incredible science being showcased and a wonderful gala dinner setting. Thanks to all the organisers.
Megan Joseph, PhD retweeted
Amazing evening and company at the Sao Juliao da Barra fort #SMLMS2024! @oliviapldalby @MDJoseph97 @ceciliazaza Julie Koziy
An amazing collaboration and congratulations to @ceciliazaza! Check out the preprint of our labs new approach to DNA-PAINT using a spinning disk with optical photon reassingment.
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