@LoxtonLab
Joined November 2022
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  • Followers74
22Media
🚨 Excited to announce the publication of @sarahjiesun's PhD work in @ImmunityCP!🚨Key finding: BCG vaccination reprograms the epigenetic landscape of human bone marrow progenitor cells, reshaping innate immune responses. Full study here in open access: authors.elsevier.com/c/1jcFF…
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SAMRC@MRCza9 Apr 2024
SAMRC launches a documentary titled "Saving Lives: Sisonke”, it chronicles the historic vaccine study rollout in South Africa. The Sisonke project, was an initiative led by Professors Glenda Gray, and Linda-Gail Bekker, CEO of @DTHF_SA More on this: shorturl.at/gjmEL
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BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination dlvr.it/T4tR9Z

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination -...

Bacillus Calmette-Guérin (BCG) is a routinely used vaccine for protecting children against Mycobacterium tuberculosis that comprises attenuated Mycobacterium bovis. BCG can also be used to protect...

pubmed.ncbi.nlm.nih.gov
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Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits | PNAS pnas.org/doi/abs/10.1073/pna…

Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in...

Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are desig...

pnas.org
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#Easter #Easter2024
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This #WorldTBDay, the TB Vax ARM has outlined 3 wins for the field to achieve by 2026 in order to effectively advance TB vaccine R&D and ensure equitable and affordable access this decade. 📋 Read the wins & sign the petition to show your support: bit.ly/Wins4TBVax
Graphic detailing the three wins to deliver new TB vaccines this decade. 1: Measurable increases in national and joint, multilateral funding and financing for TB vaccine R&D. 2: Explicit and transparent commitments and plans from developers and governments to ensure equitable access. 3: TB vaccines and TB R&D integrated into AMR and other relevant global health agendas. Endorse the TB Vax ARM wins at bit.ly/Wins4TBvax

ALT Graphic detailing the three wins to deliver new TB vaccines this decade. 1: Measurable increases in national and joint, multilateral funding and financing for TB vaccine R&D. 2: Explicit and transparent commitments and plans from developers and governments to ensure equitable access. 3: TB vaccines and TB R&D integrated into AMR and other relevant global health agendas. Endorse the TB Vax ARM wins at bit.ly/Wins4TBvax

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#PLOSPathogens: Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis ... dx.plos.org/10.1371/journal.…

Multiple genetic loci influence vaccine-induced protection against Mycobacterium tuberculosis in...

Author summary The genetic makeup of people contributes to their susceptibility to infection and to their ability to be protected by vaccines. This is the case with Mycobacterium tuberculosis and the...

journals.plos.org
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Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual participant data meta-analysis thelancet.com/journals/lanin…

Prevalence of subclinical pulmonary tuberculosis in adults in community settings: an individual...

The majority of people in the community who have pulmonary tuberculosis do not report cough, a quarter report no tuberculosis-suggestive symptoms at all, and a quarter of those not reporting any...

thelancet.com
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Just released: TB Treatment Pipeline Report 2023, detailing key updates in TB treatment R&D - including recently wrapped and in-progress treatment-shortening trials, and 22 new or repurposed drugs undergoing clinical trials. Read it here: treatmentactiongroup.org/res… #CROI2024
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At the #SAMRCMeeting the Unit Director Prof Rob Warren provided a glimpse into the innovative work happening at the Centre for #TBResearch during the @MRCza's gathering of intra and extramural research units. The Deputy Director Prof Loxton, is also representing @SuMBHG!
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Babak Javid@javid_lab9 Feb 2024
Cell state transition analysis identifies interventions that improve control of Mycobacterium tuberculosis infection by susceptible macrophages | Science Advances science.org/doi/10.1126/scia…

Cell state transition analysis identifies interventions that improve control of Mycobacterium...

Small molecule combinations increasing macrophage resistance to tuberculosis were identified using cell state transition analysis.

science.org
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Aging can influence the alveolar lining fluid and promote #Mycobacterium #tuberculosis growth and translocation: mucosalimmunology.org/articl…
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Proud to share our latest publication in Nature Communications nature.com/articles/s41467-0… @ljiresearch @sudhasinipanda @bpeters @SetteLab
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I haven't read this yet, but it's intriguing: suggests that Ag85B (and other immunodominant++ Ags??) as the 'control' for vax is bad. Mycobacterium tuberculosis Antigen 85B modifies BCG-induced anti-tuberculosis immunity and favors pathogen survival academic.oup.com/jleukbio/ar…

Mycobacterium tuberculosis antigen 85B modifies BCG-induced antituberculosis immunity and favors...

Mycobacterium tuberculosis secretory antigen 85B reduces Bacillus Calmette-Guérin–induced protective immunity and generates inflammatory CD4 Th1/Th17 cell

academic.oup.com
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TAG is proud to be part of IMPAACT4TB consortium that is supporting introduction of first-ever child-friendly rifapentine formulation for TB prevention. @TheLancetInfDis reports on consortium's work to bring this game-changing drug to affected communities: thelancet.com/journals/lanin…
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.@IAVI secured a $55 million grant from the @gatesfoundation to fund a Phase 2b trial for the TB vaccine candidate MTBVAC. The world needs improved vaccines to control TB, which requires diverse candidates to be tested. iavi.org/news-resources/pres…

IAVI and Zendal announce funding for efficacy trial of promising TB vaccine candidate in Africa

iavi.org
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Andre@AGLoxton23 Jan 2024
Important question by @richardwhite321 @WillemAHanekom and others in the fight against #Tuberculosis #vaccine development/strategy What is next for BCG revaccination to prevent tuberculosis? thelancet.com/journals/lanre…

What is next for BCG revaccination to prevent tuberculosis?

Early this year, the confirmatory phase 2b trial results on whether Bacillus Calmette–Guérin (BCG) revaccination prevents tuberculosis infection, or more accurately, whether it prevents conversion to...

thelancet.com
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Innovative Approaches to the BCG Vaccine: Potential Benefits and Implications medriva.com/vaccinations/adu… via @TWITTER_HANDLE_HERE
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📥Our 2024 calls for proposals are now open for submission! 🗓️Save-the-date for our online info day taking place on 6 February to learn more about the different opportunities & eligibility conditions ➡️shorturl.at/iHRT1 #Health #research #PublicHealth
Global Health EDCTP3@EDCTP322 Dec 2023
🚨Our 2024 funding opportunities are out! 🔬🦟Over €140 million will be allocated to #research projects working on #HIV, #malaria, NTDs, AMR and much more! ➡️Check out our 2024 Work Programme to learn more: shorturl.at/giqNS
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SAMRC@MRCza11 Jan 2024
The SAMRC is thrilled to announce the appointment of Prof Ntobeko Ntusi as its new President & CEO, effective 1 July 2024. Prof Ntusi will succeed the esteemed Prof Glenda Gray, who has been the SAMRC President for the past ten years. samrc.ac.za/press-releases/s…
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