🧠🏃 New preprint exercise neuroscience from the lab! We built a multi-organ spatial metabolomic atlas of long-term exercise in mice. Six organs. 224 metabolic features. Coordinated inter-organ remodeling. The biggest surprise? The brain reshaped its metabolism the most, region by region. We took the same approach into PS19 tau mice. Exercise cut over 70% of observable tau pathology in the hippocampus and restored the mitochondrial metabolome. Integrated proteomics + spatial metabolomics pointed to one convergent node: NADH dehydrogenase Complex I. So we tested it. We expressed yeast Ndi1 in PS19 neurons. No exercise. This alone raised brain antioxidants, restored shuttle metabolites, and reduced tau pathology. Boosting Complex I activity reproduces the core anti-tau effects of exercise. A molecular handle on why movement may protect the aging brain. biorxiv.org/content/10.64898…

I wanted to do a threadorial on our new study: "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" highlighting new tech, mouse models, spatial isotopic tracing, mechanistic insights and the connection to AI/EHR. nature.com/articles/s42255-0…

Excited to share our new paper out today in @NatureMetabolism! "Hyperglycosylation is a metabolic driver of Alzheimer’s disease" *We bridged spatial metabolomics (MALDI-MSI glycomics + lipidomics + isotopic pulse-chase tracing) directly to experimental biochemistry (genetic knockdown of glycan enzymes + glucosamine supplementation in AD models) and real-world public health data (EHR analysis showing glucosamine use linked to faster MCI-to-AD progression and worse survival). **Key takeaway: The AD brain shows conserved hyperglycosylation driven by ramped-up glycan biosynthesis — not just a byproduct, but a causal driver. Reducing it helps cognition; boosting it (e.g., via glucosamine) worsens outcomes. ***We applied cutting-edge spatial tech to functional validation and clinical translation. Full open-access paper: nature.com/articles/s42255-0… Huge thanks to the incredible team, collaborators (incl. Matt Gentry, Stefan Prokop, @ji0ngbi0n , Yi Guo, @lichenbiostat, Ralph Deberardinis & others), and the patients/families who make this work possible.