Ophthalmology Resident @UCSFMedicine || MD ‘24 @HopkinsMedicine || Biochemistry MSc ‘20 and BSc ‘18 @McGillU 🇨🇦
Baltimore, MD
Joined September 2014
- Tweets34
- Following240
- Followers64
- Likes429
Leo Shen retweeted
Determination of single-molecule loading rate during mechanotransduction in cell adhesion | Science science.org/doi/10.1126/scie…
Leo Shen retweeted
We are saddened to share the news that iconic McGill professor Jerry Pelletier has passed away. Our condolences to his family, friends and colleagues. Learn about his life and work in this profile from last year: ow.ly/m1f350PMPN8
Leo Shen retweeted
🥳Congratulations to Ph.D. student Yi Xiao (Sean) Jiang (Eisenberg group) who is a winner of the 2023 Brain Diseases Award from the UZH Foundation for his “excellent discovery of TMEM106B as the component of the FTLD amyloid fibrils”! @seanathan11 chemistry.ucla.edu/news/2023…
Leo Shen retweeted
Proud to announce my latest preprint, the culmination of my dissertation research defended two weeks ago! As co-first author, I'm excited to share the "dynamic 1D search and processive nucleosome translocations by RSC and ISW2 chromatin remodelers". doi.org/10.1101/2023.06.13.5…
Leo Shen retweeted
Excited to share our work on an improved method for detecting off-target CRISPR-Cas genome editing, published in @naturemethods! A fun and collaborative study from my time @taekjip lab, building on seminal work on off-target detection @jcornlab, a 🧵:
nature.com/articles/s41592-0…
Privilege to be involved with this incredible team! Please check it out 🙌
Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq+
@rogerszou led this study with @yliu_UofU @Oscarreyesgaido Max Konig, Leo Shen, @FranklinJ_ @AlbertoMarinG1
nature.com/articles/s41592-0…
Leo Shen retweeted
Improving the sensitivity of in vivo CRISPR off-target detection with DISCOVER-Seq+
@rogerszou led this study with @yliu_UofU @Oscarreyesgaido Max Konig, Leo Shen, @FranklinJ_ @AlbertoMarinG1
nature.com/articles/s41592-0…
Leo Shen retweeted
Discover-seq+ developed by @taekjip, @rogerszou and colleagues is a high-sensitivity method to map the off-target effects of in vivo genome editing.
nature.com/articles/s41592-0…
Leo Shen retweeted
Outstanding histopathological endeavor to find that Otolith Membrane Herniation, not Semicircular Canal Duct Dilation impacts the caloric response in MD patients - check Shen et al. @JohnsHopkins rdcu.be/c2lXF
Leo Shen retweeted
Histology from @hopkins_ent and @MassEyeAndEar
found evidence that otolith membrane herniation is associated with decreased caloric responses in Ménière’s Disease, but no evidence of canal duct dilation. Lead by @LeoLShen & @WardensMD
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Leo Shen retweeted
An innovative 3D #gear, invented by three Japanese researchers
This amazing concept gives a potential for many applications in health, robotics and many other mechanical fields
Active ball joint mechanism (ABENICS)
#innovation #tech ##3D #science
Leo Shen retweeted
Excited to share our new study @NatureCellBio, using CRISPR gRNAs simultaneously targeting epigenetically diverse genomic sites to study DNA damage/repair! Grateful to wonderful teammates and mentors @taekjip, @AlbertoMarinG1 @yliu_UofU @kalhorlab @LeoLShen @HopkinsMDPhD 1/4
Just in time for the new rings series. One guide to rule them all in @NatureCellBio. Congratulations to @rogerszou @AlbertoMarinG1 who led the effort. @yliu_UofU @kalhorlab.nature.com/articles/s41556-0…
Leo Shen retweeted
My first postdoc paper with @taekjip is now out in @NatureCellBio! We developed multi-target CRISPR to measure Cas9 dynamics and DSB repair in high-throughput. Huge thanks to @rogerszou and @taekjip for their support and guidance, and to @yliu_UofU, @kalhorlab, @LeoLShen!
Leo Shen retweeted
Just in time for the new rings series. One guide to rule them all in @NatureCellBio. Congratulations to @rogerszou @AlbertoMarinG1 who led the effort. @yliu_UofU @kalhorlab.nature.com/articles/s41556-0…
Leo Shen retweeted
Thrilled to announce that I have started as an Assistant Professor @UofUBiochem today! My lab will develop on-demand tools for precision genome manipulation and study DNA repair mechanisms in living systems. Hiring at all levels (postdoc, lab tech, grad, undergrad), please RT!
Leo Shen retweeted
Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature.
nature.com/articles/s41586-0…
An illustrated & updated tweetorial… [1/24]
Leo Shen retweeted
Our Covid-19 lockdown project is finally out. @rogerszou led this collaboration with Geraldine Seydoux and Yuka Manabe.
nature.com/articles/s42003-0…
Leo Shen retweeted
Congratulations to @rogerszou @Alberto59308808 for leading this effort on massively parallel CRISPR & DNA repair dynamics. @yliu_jhu @kalhorlab @LeoLShen One guide. One hundred diverse targets. Cas9 departs from PAM distal product rapidly in cellulo. biorxiv.org/content/10.1101/…
Leo Shen retweeted
Congratulations to @BiophysicsJHMed Department members Taekjip Ha @taekjip and Cynthia Wolberger @CWolberger , who were elected to the National Academy of Medicine! 🎉
Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/national-academy-of-…
New to this whole Twitter thing but wanted to share my first, first-co-authored paper published in @NAR_Open. Check it out here: bit.ly/3lOXYSB! The work involves a CRISPR-based screen that identifies mutants resistant to the translation inhibitor, hippuristanol.
3 EIF4A1 mutants were uncovered: T242P, G361C, and G370S. These were then biochemically validated in vitro and in vivo. Ribosome profiling was then used to determine hippuristanol-sensitive transcripts. The mutants were then used to validate these findings!