Official Twitter account of the Leicester Institute of Structural and Chemical Biology
University of Leicester
Joined July 2016
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Congratulations @HodgUoL @joshpsmalley @LeicsRam for publication of "Cereblon-recruiting proteolysis targeting chimeras (PROTACs) can determine the selective degradation of HDAC1 over HDAC3" in @ChemCommun pubs.rsc.org/en/content/arti…
Congrats @manonlachmann and @_PatriRM and co-authors on this perspective in @ChemicalScience
"The missing pieces in the catalytic cycle of [FeFe] hydrogenases"
pubs.rsc.org/en/content/arti…
Very excited about these positions: 2 positions, choice of 4 projects: le.ac.uk/research/institutes…
with @drpetermoody @YolandaMarkaki @HannaSciences @HodgUoL @hopkinson862 and others.
To apply:
jobs.le.ac.uk/vacancies/9767…
More information on AMBER:
le.ac.uk/research/institutes…
Deadline 6 Sept
Great to hear our covalent molecular glues paper has been selected as one of the most popular chemical biology articles by @ChemicalScience in 2023. Congratulations Carlo, Danielle, @CossarPeter @TUeindhoven @RichardDoveston @LeicStructBio
@UoBbiosciences
blogs.rsc.org/sc/2024/04/25/…
27 June event by @IPH_UK with @Leics_AHP and @MedilinkMids in Kingpower Stadium, LCFC
Register here: tickettailor.com/events/inst… There'll be great networking opportunities with academics, clinicians, businesses, and funders.
See you there!
Congratulations Taha, @De_Biascio_group and @ChristosGSavva. Hope it gets published soon
Check out our latest preprint! We use #CryoEM continuous heterogeneity analysis to model how ATP-hydrolysis triggers structural changes in an AAA+ helicase that drive DNA unwinding – a fundamental step in replication!
biorxiv.org/content/10.1101/…
#CryoEM #DNAReplication @structurabio
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis. Using SPR, proximity ligation, co-immunoprecipitation, small molecule inhibitors: gal-3 interacts directly with the TGF-β1 signaling cascade. By @bedoctored etc sciencedirect.com/science/ar…
Preprint Restraint Validation of Biomolecular Structures Determined by NMR in the Protein Data Bank @ccpnmr
Addressing the challenge of validation of experimental biomolecular NMR structures against restraint data.
ebi.ac.uk/pdbe/news/wwpdb-pr…
Aster-B–dependent estradiol synthesis protects female mice from diet-induced obesity @Beatirz11 Aster-B–dependent nonvesicular cholesterol transport regulates estradiol production and protects females from obesity doi.org/10.1172/JCI173002.
2′-19F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions
@BurleyResearch @RNAsLOLA
frontiersin.org/articles/10.…
FluoroTensor: identification and tracking of colocalised molecules and their stoichiometries in multi-colour single molecule imaging via deep learning: convolutional neural networks yields accurate analysis quickly. FluoroTensor, in Python with great UI
sciencedirect.com/science/ar…
