Making biotech more legible. Hosted by @shmkdbr
Joined October 2025
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Would you choose your healthiest embryo?
@herasight ranks embryos by predicted disease risk, height, autism risk, and even IQ. I sat down with @JonathanAnomaly to separate the real science from hype and dig into the ethics of creating future people.
Full episode:
Embryo selection and the science of creating future people with @JonathanAnomaly from @herasight
00:00 - From Academia to Herasight
07:12 - Is Embryo Selection Controversial
11:31 - Polygenic Scores Explained
21:14 - Why Insurance Hasn’t Covered It
28:18 - Who Uses Screening and Why
32:35 - IVF Limits and Future Tech
36:52 - Selection vs Editing and Gattaca Fears
42:07 - Ethical Boundaries
43:01 - Breakthrough Imputation Proof
48:49 - Winning Clinics Over
51:18 - Ethics Backlash Explained
55:28 - Preference Cascade Theory
59:19 - Blank Slate Debate
01:03:09 - Pleiotropy Tradeoffs
01:08:29 - Autism Risk Predictor
01:13:37 - Repro Tech And Birth Rates
01:20:17 - Relationships And Family Futures
01:24:25 -Books Recs
Embryo selection and the science of creating future people with @JonathanAnomaly from @herasight
00:00 - From Academia to Herasight
07:12 - Is Embryo Selection Controversial
11:31 - Polygenic Scores Explained
21:14 - Why Insurance Hasn’t Covered It
28:18 - Who Uses Screening and Why
32:35 - IVF Limits and Future Tech
36:52 - Selection vs Editing and Gattaca Fears
42:07 - Ethical Boundaries
43:01 - Breakthrough Imputation Proof
48:49 - Winning Clinics Over
51:18 - Ethics Backlash Explained
55:28 - Preference Cascade Theory
59:19 - Blank Slate Debate
01:03:09 - Pleiotropy Tradeoffs
01:08:29 - Autism Risk Predictor
01:13:37 - Repro Tech And Birth Rates
01:20:17 - Relationships And Family Futures
01:24:25 -Books Recs
Tomorrow with @JonathanAnomaly from @herasight
We discuss the tech behind embryo selection, how to reduce suffering, and the liberterian ethics underlying it all
What if an MRI could write, not just read?
Talked with @consciousrepo from aion.bio about reclaiming MRI as a bioelectric mapping device, making imaging more accessible, and what a “medbed” actually means if you take the physics seriously
Full ep:
Read + Write MRIs with @consciousrepo of Aion.Bio
Michael Levin’s latest paper - 0:34
Benjamin’s journey to bioelectricity - 3:37
How MRI works - 11:52
Longitudinal imaging - 17:11
MRI vs. ultrasound - 26:15
Making MRI more accessible - 28:57
Bioelectricity and the medbed - 36:39
Building in St. Louis - 57:39
Read + Write MRIs with @consciousrepo of Aion.Bio
Michael Levin’s latest paper - 0:34
Benjamin’s journey to bioelectricity - 3:37
How MRI works - 11:52
Longitudinal imaging - 17:11
MRI vs. ultrasound - 26:15
Making MRI more accessible - 28:57
Bioelectricity and the medbed - 36:39
Building in St. Louis - 57:39
Legible retweeted
@shmkdbr and I discuss the edges of biotech from DeSci to human evidence to where biotech is intersecting with culture with the emergence of looksmaxxing.
Ep 5: Creative Destruction in Biotech with @shelbynewsad from @CompoundVC
Chapters
07:21 Platform vs Product
14:25 Creative Destruction in Biotech
23:54 Decentralized Science and Crypto
30:35 Careful with Gray Label Peptides
35:34 Accelerating Human Clinical Trials
45:36 The Role of Virtual Cell Models
50:01 The Evolution of Bio-Manufacturing
53:34 Consumer Biotech: The Next Frontier
58:51 Implications of Looksmaxxing
Ep 5: Creative Destruction in Biotech with @shelbynewsad from @CompoundVC
Chapters
07:21 Platform vs Product
14:25 Creative Destruction in Biotech
23:54 Decentralized Science and Crypto
30:35 Careful with Gray Label Peptides
35:34 Accelerating Human Clinical Trials
45:36 The Role of Virtual Cell Models
50:01 The Evolution of Bio-Manufacturing
53:34 Consumer Biotech: The Next Frontier
58:51 Implications of Looksmaxxing
I’ve long admired Shelby's thesis work in publicly sharing how biotech could unfold over the next decade.
We talk about everything from decentralized clinical trials to incumbent vs startup advantages in biotech. Hope you enjoy!
YouTube: youtube.com/watch?v=i68Kx9Js…
Tomorrow with @shelbynewsad from @CompoundVC
We discuss consumer biotech, the problem with peptides, the implications of looksmaxxing, and much more
Legible retweeted
Being in SF this week has made me realize how underappreciated Biotech really is, two large events, Substack debate and Hamilton society have a Biotech focus yet very few founders and VCs I meet at all the parties and events working on/investing in Biotech. The technology is there and its in the zeitgeist and people care about it and it is obviously going to have a massive impact on our future
There is so much alpha in Biotech right now, especially compared to AI, on the founder and VC side its insane how its not being exploited
Legible retweeted
Lfg - learn about Gilbert Ling & Aion here!
Ep 4: Bioelectricity with @anabology
Rethinking cell membranes, origins of MRI, building Med Beds, and more
00:00 - Background and Bioelectricity
10:19 - Gilbert Ling
28:27 - Raymond Damidian
45:23 - What is Structured Water?
49:32 - Are Small Molecule Approaches a Dead End?
59:30 - Building Aion Biosciences in St Louis. MO
01:05:12 - Consciousness and Origin of Life
01:11:46 - Cosmetics Sidequest (skin.food)
Ep 4: Bioelectricity with @anabology
Rethinking cell membranes, origins of MRI, building Med Beds, and more
00:00 - Background and Bioelectricity
10:19 - Gilbert Ling
28:27 - Raymond Damidian
45:23 - What is Structured Water?
49:32 - Are Small Molecule Approaches a Dead End?
59:30 - Building Aion Biosciences in St Louis. MO
01:05:12 - Consciousness and Origin of Life
01:11:46 - Cosmetics Sidequest (skin.food)
Ep 4: Bioelectricity with @anabology
Rethinking cell membranes, origins of MRI, building Med Beds, and more
00:00 - Background and Bioelectricity
10:19 - Gilbert Ling
28:27 - Raymond Damidian
45:23 - What is Structured Water?
49:32 - Are Small Molecule Approaches a Dead End?
59:30 - Building Aion Biosciences in St Louis. MO
01:05:12 - Consciousness and Origin of Life
01:11:46 - Cosmetics Sidequest (skin.food)
YouTube - youtube.com/watch?v=WXQoFqvq…
S*bstack - substack.com/@shoumikdabir/p…
Relevant links -
skin.food
aion.bio
literature.bio
Legible retweeted
Unc has still got it
Jake (@SynBio1) talks about the current state of biotech, and more importantly - where the hell AI really fits into biotech.
Interesting listen
Ep 3: Read, Write, Grow with @SynBio1. We discuss the
100 year vision for synthetic biology, biotech's product problem, biomanufacturing, and more.
00:00 - Jake Wintermute’s Journey in Biotech
08:32 - The Vision for Synthetic Biology
15:59 - Bio-Manufacturing as a Gateway
18:48 - Platform vs Product Companies in Biotech
25:39 - The Role of AI in Drug Discovery
29:34 - Addressing Bottlenecks in Clinical Trials
31:25 - Communicating Synthetic Biology
38:35 - Consumer-Facing Biotechnologies