Here is a short synopsis of the OMB proposed rule, “Regulation for Federal Financial Assistance” which would revise federal grant, cooperative agreement, and financial-assistance requirements. HHS is included and would adopt the revised 2 CFR part 200 for HHS awards. If finalized, the rule would not itself reduce NIH’s congressional appropriation, but it could reduce, delay, redirect, condition, or terminate NIH funding for some projects by changing how awards are reviewed, budgeted, monitored, continued, and closed.
Peer review: NIH peer review would remain advisory. Discretionary awards would require pre-issuance review by senior appointees for consistency with law, agency priorities, national interest, and, where applicable, the President’s policy priorities. This would make funding less predictable.
Dissemination costs: Conference participation, publication charges, open-access fees, memberships, and related costs would need clearer justification and generally prior approval. Subscriptions would be unallowable.
Termination risk: Awards could be terminated if the agency determines the project no longer advances program goals, agency priorities, or national interest. Agencies could also withhold new or continuation funding.
International research: Direct R&D awards would generally need to go to U.S.-organized entities. Foreign sites and subawards could still participate under eligible U.S. awardees, but would need stronger justification under a “domestic-first” framework.
Indirect costs: The proposal would make lower indirect-cost rates a review preference when other factors are equal.
Bottom line: NIH applications would need clearer alignment with NIH mission, statutory purpose, administration priorities, national interest, reproducibility, and measurable milestones. Health equity, DEI-linked, gender identity, transgender health, minors’ gender-related care, or disparate-impact research would require careful review before submission.
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The therapies of the future depend on the research we support today. The ASH Foundation supports the research that make future therapies possible, helping ensure the next generation of discoveries can move from idea to impact. Donate today: ow.ly/CpJ250Z19l0
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MYELOD2026
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MYELOID2026 registration is now closed. We are preparing to welcome the myeloid peeps to Cincinnati! myeloidmeeting.org
MYELOID2026 agenda and menus are up. myeloidmeeting.org
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Step into the science! ASH Scientific Committees are looking for members to guide the Annual Meeting program, highlight novel research, and advance interdisciplinary discoveries in hematology.
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ASH strongly opposes the Administration’s proposed 12.3% cut to NIH. These reductions would devastate hematology research, harm patients, & undermine U.S. leadership in medical innovation. 🔗 ow.ly/KXfe50YCXnm
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